Interpolyelectrolyte
complexes
Eudragit®
EPO/L100
received
in
different
pH
were
characterized
by
degree
of
swelling
mimicking
fasted
stomach
medium
(0.1
M
HCl)
and
saved
their
shape
during
6
hours
the
experiment.
The
microenvironmental
changes
IPECs
structure
testing
inves-tigated
using
FT-IR
spectroscopy,
thermal
elemental
analysis.
Both
samples
transformed
to
a
similar
with
approximately
same
composition.
IPEC
showed
bioadhesive
properties
that
was
not
significantly
from
positive
control
(Carbopol)
test
mucin
compacts.
release
rate
metronidazole
(class
I
BCS)
matrices
increased
increasing
swelling.
1
provided
49.62
±
6.20%
2
–
87.69
5.15
%
after
HCl).
Total
amount
released
acyclovir
III
25.76
5.67
21.48
5.00
%.
Release
both
drugs
controlled
relaxation
polymeric
chains
according
Peppas-Sahlin
model.
According
results,
investigated
interpolymer
are
perspective
for
further
evalua-tion
as
carriers
gastroretentive
systems.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 790 - 790
Опубликована: Июнь 11, 2024
Gastroretentive
drug
delivery
systems
(GRDDSs)
have
gained
substantial
attention
in
the
last
20
years
due
to
their
ability
retain
stomach
for
an
extended
time,
thus
promoting
release
and
high
bioavailability
a
broad
range
of
active
pharmaceutical
ingredients
(APIs)
that
are
pH-sensitive
and/or
narrow
absorption
window.
The
currently
existing
GRDDSs
include
floating,
expanding,
mucoadhesive,
magnetic,
raft-forming,
ion-exchanging,
high-density
systems.
Although
there
seven
types
systems,
main
focus
is
on
mucoadhesive
produced
by
various
techniques,
3D
printing
being
one
most
revolutionary
studied
ones.
This
review
assesses
newest
production
technologies
briefly
describes
vitro
vivo
evaluation
methods,
with
aim
providing
better
overall
understanding
as
novel
emerging
strategy
targeted
delivery.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Фев. 3, 2025
The
development
of
gastroretentive
drug
delivery
systems
is
one
such
instance,
which
was
developed
to
improve
the
oral
bioavailability
and
effectiveness
drugs,
has
a
poor
absorption
window
in
upper
GIT
and/or
triggers
local
activity
as
duodenal
stomach
activity.
In
this
work,
objective
sintering
dosage
forms
sustain
release
levofloxacin
gastric
region
for
an
extended
period
time.
Selective
laser
(SLS)-mediated
powder
bed
fusion
3D
printing
technology
utilized
design
fabricate
modified-release
floating-hollow
capsular
device
(GRF-HCD)
three
distinct
capsule
sizes
namely,
000,
00,
0
with
aid
pharmaceutical
grade
polymers
(combinations
Kolliphor
P188
Kollidon
SR
1:1
ratio).
Sintered
GRF-HCD
further
subjected
morphological
analysis,
weight
variation,
swelling
index.
addition,
vitro
vivo
buoyancy
studies
were
performed
animal
model
using
X-ray
imaging.
Finally,
from
simulated
pH
condition
(pH-1.2)
upto
12
h.
Levofloxacin
concentration
then
quantified
validated
RP-HPLC
method.
floating
behaviour
mimicked
floating,
where
retained
rabbit
will
help
longer
maintained
maximum
region.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(11), С. 1521 - 1521
Опубликована: Окт. 26, 2023
In
recent
years,
the
3D
printing
of
personalized
drug
formulations
has
attracted
attention
medical
practitioners
and
academics.
However,
there
is
a
lack
data-based
analyses
on
hotspots
trends
research
in
this
field.
Therefore,
study,
we
performed
bibliometric
analysis
to
summarize
field
formulation
from
2012
2022.
This
study
was
based
Web
Science
Core
Collection
Database,
total
442
eligible
publications
were
screened.
Using
VOSviewer
online
websites
for
scientific
mapping,
it
observed
that
annual
have
shown
significant
growth
trend
over
last
decade.
The
United
Kingdom
States,
which
account
45.5%
number
publications,
are
main
drivers
International
Journal
Pharmaceutics
University
College
London
most
prolific
cited
journals
institutions.
researchers
with
contributions
Basit,
Abdul
W.
Goyanes
Alvaro.
keyword
concluded
current
“drug
release”
dosage
forms”.
conclusion,
broad
application
prospects
drugs,
will
bring
pharmaceutical
industry
into
new
era
innovation.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
663, С. 124543 - 124543
Опубликована: Авг. 1, 2024
Gastrointestinal
(GI)
environment
is
influenced
by
several
factors
(gender,
genetics,
sex,
disease
state,
food)
leading
to
oral
drug
absorption
variability
or
low
bioavailability.
In
this
scenario,
gastroretentive
delivery
systems
(GRDDS)
have
been
developed
in
order
solve
problems,
lead
a
more
effective
local
therapy
allow
sustained
release
during
longer
time
period
than
the
typical
dosage
forms.
Among
all
GRDDS,
floating
seem
provide
promising
and
practical
approach
for
achieving
long
intra-gastric
residence
profile.
last
years,
novel
technique
being
used
manufacture
kind
of
systems:
three-dimensional
(3D)
printing
technology.
This
provides
versatile
easy
process
personalized
systems.
work
presents
systematic
review
main
3D
based
designs
proposed
up
date
We
also
summarized
most
important
parameters
involved
buoyancy
systems,
facilitate
scale
technology
industrial
level.
Finally,
section
discussing
about
influence
materials
release,
their
biocompatibility
safety
considerations
included.
Scientia Pharmaceutica,
Год журнала:
2024,
Номер
92(1), С. 14 - 14
Опубликована: Фев. 22, 2024
The
aim
of
this
study
was
the
analysis
interpolyelectrolyte
complexes
(IPECs)
based
on
Eudragit®
EPO
and
L100
as
prospective
carriers
for
gastroretentive
drug
delivery
systems
(GRDDS)
using
two
model
drugs:
metronidazole
(MZ)
acyclovir
(ACR).
EPO/L100
IPECs
with
different
pH
concentrations
were
characterized
by
degrees
swelling
in
mimicking
fasted
stomach
medium
(0.1
M
HCl)
saved
their
shape
6
h.
microenvironmental
changes
IPEC
structures
acidic
investigated
FT-IR
spectroscopy,
thermal
elemental
analysis.
samples
showed
bioadhesive
properties
that
not
significantly
from
positive
control
(Carbopol)
test
mucin
compacts.
release
rate
(class
I
BCS)
matrices
increased
increasing
degree
swelling.
1
provided
49.62
±
6.20%
2
reached
87.69
5.15%
after
h
HCl).
total
amount
released
III
25.76
5.67%
21.48
5.00%.
Release
both
drugs
controlled
relaxation
polymeric
chains
according
to
Peppas–Sahlin
model.
According
received
results,
interpolymer
are
prospects
further
evaluation
systems.
Journal of Controlled Release,
Год журнала:
2024,
Номер
373, С. 463 - 480
Опубликована: Июль 25, 2024
3D
printing
technologies
confer
an
unparalleled
degree
of
control
over
the
material
distribution
on
structures
they
produce,
which
has
led
them
to
become
extremely
attractive
research
topic
in
pharmaceutical
dosage
form
development,
especially
for
design
personalized
treatments.
With
fine
tuning
selection
and
careful
design,
these
allow
tailor
not
only
amount
drug
administered
but
biopharmaceutical
behaviour
forms
as
well.
While
fused
deposition
modelling
(FDM)
is
still
most
studied
technology
this
area,
others
are
gaining
more
relevance,
many
new
exciting
developed
during
2022
2023.
Considering
that
technologies,
time,
will
join
current
manufacturing
methods
with
ever-increasing
knowledge
topic,
our
review
aims
explore
advantages
limitations
employed
development
oral
forms,
giving
special
focus
important
aspects
governing
resulting
release
profiles.
ACS Omega,
Год журнала:
2024,
Номер
9(31), С. 34140 - 34150
Опубликована: Июль 26, 2024
This
is
the
first
study
that
explores
blending
polylactic
acid
(PLA)
with
various
biomasses,
including
food
wastes-brewer's
spent
grain
(BSG),
coffee
grounds
(SCG),
sesame
cake
(SC),
and
thermoplastic
starch
(TPS)
biomass
to
create
composite
gastric
floating
drug
delivery
systems
(GFDDS)
through
3D
printing.
The
aim
investigate
influence
of
percentage,
type,
printing
parameters
on
their
corresponding
release
profiles.
3D-printed
(3DP)
filaments
were
prepared
by
biomasses
PLA
before
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(17), С. 2723 - 2766
Опубликована: Авг. 5, 2024
The
objective
of
this
study
is
to
collect
the
significant
advancements
3D
printed
medical
devices
in
biomedical
area
recent
years.
Especially
related
a
range
diseases
and
polymers
employed
drug
administration.
To
address
existing
limitations
constraints
associated
with
method
used
for
producing
devices,
order
optimize
their
suitability
degradation.
compilation
use
research
papers,
reports,
patents
that
are
relevant
key
keywords
improve
comprehension.
According
thorough
investigation,
it
can
be
inferred
Printing
method,
specifically
Fuse
Deposition
Modeling
(FDM),
most
suitable
convenient
approach
preparing
devices.
This
provides
an
analysis
summary
development
trend
implantable
focusing
on
production
process,
materials
specially
polymers,
typical
items
printing
technology.
offers
comprehensive
examination
nanocarrier
its
corresponding
discoveries.
FDM
which
already
facing
challenges
terms
achieving
optimal
performance
cost
reduction,
will
experience
remarkable
advantages
from
highly
valuable
showcase
efficacy
3D-printing
applications
through
research,
highlighting
technological
offers.
article
overview
discoveries
3D-printed
offering
insights
into
study.
