Interpolyelectrolyte
complexes
Eudragit®
EPO/L100
received
in
different
pH
were
characterized
by
degree
of
swelling
mimicking
fasted
stomach
medium
(0.1
M
HCl)
and
saved
their
shape
during
6
hours
the
experiment.
The
microenvironmental
changes
IPECs
structure
testing
inves-tigated
using
FT-IR
spectroscopy,
thermal
elemental
analysis.
Both
samples
transformed
to
a
similar
with
approximately
same
composition.
IPEC
showed
bioadhesive
properties
that
was
not
significantly
from
positive
control
(Carbopol)
test
mucin
compacts.
release
rate
metronidazole
(class
I
BCS)
matrices
increased
increasing
swelling.
1
provided
49.62
±
6.20%
2
–
87.69
5.15
%
after
HCl).
Total
amount
released
acyclovir
III
25.76
5.67
21.48
5.00
%.
Release
both
drugs
controlled
relaxation
polymeric
chains
according
Peppas-Sahlin
model.
According
results,
investigated
interpolymer
are
perspective
for
further
evalua-tion
as
carriers
gastroretentive
systems.
International Journal of Advanced Research in Science Communication and Technology,
Год журнала:
2024,
Номер
unknown, С. 41 - 51
Опубликована: Март 18, 2024
Gastroretentive
tablets
have
emerged
as
a
promising
platform
for
controlled
drug
delivery,
offering
the
potential
prolonged
gastric
residence
time
and
enhanced
therapeutic
outcomes.
This
comprehensive
review
explores
paradigm
shift
towards
patient-centric
approaches
in
development
of
gastroretentive
tablets.
The
journey
begins
with
an
examination
historical
evolution
technologies,
tracing
advancements
formulation
techniques,
materials,
technologies
that
paved
way
designs.
delves
into
strategies
tailored
diverse
populations,
including
pediatrics
geriatrics.
It
highlights
importance
considering
patient-specific
needs,
preferences,
physiological
characteristics
optimizing
dosage
forms.
Regulatory
considerations
compliance-enhancing
features
are
scrutinized,
providing
insights
delicate
balance
between
personalized
medicine
regulatory
expectations.
Real-world
applications
illuminated
through
case
studies,
success
stories
across
pediatric,
geriatric,
contexts.
Clinical
outcomes,
adherence
metrics
patient
satisfaction,
provide
tangible
evidence
impact
Challenges
implementation
critically
examined,
focus
on
technical
hurdles
navigating
evolving
landscapes.
conclusion
distills
key
findings
outlines
implications
future
research
clinical
practice,
emphasizing
continued
innovation,
strategic
engagement,
interdisciplinary
collaboration.
serves
resource
researchers,
clinicians,
professionals
engaged
advancing
offers
roadmap
integration
innovative
fostering
patient-centered
approach
delivery
systems.
Pharmaceutical Development and Technology,
Год журнала:
2024,
Номер
29(5), С. 517 - 529
Опубликована: Май 9, 2024
The
present
study
aims
to
investigate
the
potential
of
3D
printing
technique
design
gastroretentive
floating
tablets
(GFTs)
for
modifying
drug
release
profile
an
immediate-release
tablet.
A
3D-printed
shell
enclosing
a
captopril
tablet
was
designed
having
varying
number
drug-release
windows.
impact
geometrical
changes
in
delivery
system
and
thermal
cross-linking
polymers
were
evaluated
observe
influence
on
ability
release.
Water
uptake,
water
insolubilization,
Differential
Scanning
Calorimetry
(DSC),
Attenuated
Total
Reflection-Fourier
Transform
Infrared
Spectroscopy
(ATR-FTIR)
performed
assess
degree
polyvinyl
alcohol
(PVA)
filament.
GFT9
considered
optimized
gastric
that
exhibited
>12
hours
total
time
with
zero
lag
successfully
accomplished
modified-drug
by
exhibiting
>80%
8
hours.
zero-order
model,
r2
value
0.9923,
best
fitted
kinetic
data
GFT9,
which
followed
super
case
II
transport
mechanism
n
0.95.
device
(GFT9)
also
highest
MDT
values
(238.55),
representing
slow
from
due
crosslinking
presence
single
drug-releasing
window
device.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 717 - 717
Опубликована: Май 27, 2024
Gastric
acid
secretion
is
closely
associated
with
the
development
and
treatment
of
chronic
gastritis,
gastric
ulcers,
reflux
esophagitis.
However,
affected
by
complex
physiological
pathological
factors,
real-time
detection
control
are
complicated
expensive.
A
delivery
system
for
antacids
therapeutics
in
response
to
low
pH
stomach
holds
promise
smart
personalized
diseases.
In
this
study,
pH-responsive
modular
units
were
used
assemble
various
devices
self-regulation
drug
stomach.
The
unit
a
release
window
50
mm2
could
respond
self-regulate
within
10
min,
which
related
its
downward
floatation
internal
gas
production.
assembled
stably
float
medium
detach
sequentially
at
specific
times.
loaded
exhibited
under
conditions.
addition,
suppressors
multi-pulse
or
prolong
after
rapid
neutralization
acid.
Compared
traditional
coating
technology,
3D
printing
can
print
shell
layer
layer,
flexibly
adjust
external
structure
composition,
it
into
multi-level
system.
coating,
3D-printed
shells
have
advantage
flexible
adjustment
easy
This
provides
universal
strategy
diseases
abnormal
secretion,
especially
delivering
acid-unstable
drugs.
International Journal of Pharmaceutical Sciences Review and Research,
Год журнала:
2024,
Номер
84(5)
Опубликована: Май 1, 2024
Since
floating
drug
delivery
systems
may
solve
the
disadvantages
associated
with
traditional
systems,
such
as
frequent
dosing,
limited
bioavailability,
etc.,
in
comparison
to
quick
stomach
emptying
time,
they
have
attracted
a
lot
of
attention
recent
decades.A
system
that
stays
for
an
adequate
amount
time
and
delivers
active
medication
continuously
is
known
ideal
system.These
continue
float
over
contents.prolonging
pharmacological
effects
enhancing
drug's
bioavailability.This
overview
gastroretentive
tablets
was
written
gather
research
on
topic,
well
information
tablets'
principles,
benefits,
categorization,
preparation,
assessment
methods,
list
medications
been
developed
tablets.formulation
evaluation
future
scope
tablets.The
review
concentrated
types
formulation
aspect
effervescent
systems.The
review's
objective
being
done
this
medicine
device.The
addresses
several
aspects
impact
retention
(long
duration)
offers
useful
about
pharmaceutical
side
it.
Currently,
fused
deposition
modeling
(FDM)
is
a
3D
printing
technology
that
has
been
most
widely
used
to
develop
innovative
drug
delivery
approaches
for
overcoming
the
limitations
of
oral
administration.
Propranolol
short
plasma
half-life
and
well
soluble
in
acidic
environments.
Thus,
this
study
aimed
gastro-floating
printed
device
(GFD)
sustain
release
propranolol
stomach
as
gastro-retentive
system.
The
polylactic
acid
(PLA)
was
selected
fabricate
GFD.
An
air
chamber
included
interior
construction
GFD
design
buoyancy.
number
open
channels
on
side
wall
modified
regulate
release.
gel
formulation
composed
mixture
polyvinylpyrrolidone
(PVP)
at
weight
ratio
6:5
then
loaded
into
GFDs
using
syringe.
exhibited
floating
ability
more
than
24
h
with
low
standard
deviation
(SD)
values
variation
shape
dimension.
from
shows
sustained
properties
simulated
gastric
environment
without
lag
time.
4
5
6
h.
In
addition,
duration
8
achieved
2
3
channels.
kinetic
best
fit
zero-order.
could
be
designed
control
according
each
patient,
which
potential
applying
personalized
various
medications.
Graphical
abstract
Interpolyelectrolyte
complexes
Eudragit®
EPO/L100
received
in
different
pH
were
characterized
by
degree
of
swelling
mimicking
fasted
stomach
medium
(0.1
M
HCl)
and
saved
their
shape
during
6
hours
the
experiment.
The
microenvironmental
changes
IPECs
structure
testing
inves-tigated
using
FT-IR
spectroscopy,
thermal
elemental
analysis.
Both
samples
transformed
to
a
similar
with
approximately
same
composition.
IPEC
showed
bioadhesive
properties
that
was
not
significantly
from
positive
control
(Carbopol)
test
mucin
compacts.
release
rate
metronidazole
(class
I
BCS)
matrices
increased
increasing
swelling.
1
provided
49.62
±
6.20%
2
–
87.69
5.15
%
after
HCl).
Total
amount
released
acyclovir
III
25.76
5.67
21.48
5.00
%.
Release
both
drugs
controlled
relaxation
polymeric
chains
according
Peppas-Sahlin
model.
According
results,
investigated
interpolymer
are
perspective
for
further
evalua-tion
as
carriers
gastroretentive
systems.
Interpolyelectrolyte
complexes
Eudragit®
EPO/L100
received
in
different
pH
were
characterized
by
degree
of
swelling
mimicking
fasted
stomach
medium
(0.1
M
HCl)
and
saved
their
shape
during
6
hours
the
experiment.
The
microenvironmental
changes
IPECs
structure
testing
inves-tigated
using
FT-IR
spectroscopy,
thermal
elemental
analysis.
Both
samples
transformed
to
a
similar
with
approximately
same
composition.
IPEC
showed
bioadhesive
properties
that
was
not
significantly
from
positive
control
(Carbopol)
test
mucin
compacts.
release
rate
metronidazole
(class
I
BCS)
matrices
increased
increasing
swelling.
1
provided
49.62
±
6.20%
2
–
87.69
5.15
%
after
HCl).
Total
amount
released
acyclovir
III
25.76
5.67
21.48
5.00
%.
Release
both
drugs
controlled
relaxation
polymeric
chains
according
Peppas-Sahlin
model.
According
results,
investigated
interpolymer
are
perspective
for
further
evalua-tion
as
carriers
gastroretentive
systems.
