Food and Bioprocess Technology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 25, 2024
Язык: Английский
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 11, 2024
Wound management is a critical aspect of healthcare, necessitating effective and innovative wound dressing materials. Many existing dressings lack effectiveness exhibit limitations, including poor antimicrobial activity, toxicity, inadequate moisture regulation, weak mechanical performance. The aim this study to develop natural-based nanofibrous structure that possesses desirable characteristics for use as dressing. chemical analysis confirmed the successful creation Zein (Ze) (25% w/v) /gelatin (Gel) (10% /chitosan (CS) (2% /Polyvinyl alcohol (PVA) scaffolds loaded with vitamin E tocopheryl polyethylene glycol succinate (Vit E). swelling percentages nanofiber (NF), NF + Vit E, cross-linked (CNF), CNF were 49%, 110%, 410%, 676%, respectively; degradation rates NF, CNF, 29.57 ± 5.06%, 33.78 7.8%, 14.03 7.52%, 43 6.27%, respectively. antibacterial properties demonstrated impregnated antibiotics reduced Escherichia coli (E. coli) counts by approximately 27–28% Staphylococcus aureus (S. aureus) about 34–35% compared negative control. In conclusion, Ze/Gel/CS/PVA have potential suitable materials because environmentally friendly contribute sustainable care controlled ensures breakdown harmlessly.
Язык: Английский
Процитировано
9
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137318 - 137318
Опубликована: Ноя. 14, 2024
Язык: Английский
Процитировано
8
Polymers, Год журнала: 2024, Номер 16(9), С. 1217 - 1217
Опубликована: Апрель 26, 2024
Polyvinylpyrrolidone (PVP) is a synthetic polymer that holds significance in various fields such as biomedical, medical, and electronics, due to its biocompatibility exceptional dielectric properties. Electrospinning the most commonly used tool fabricate fibers because of convenience wide choice parameter optimization. Various parameters, including solution molarity, flow rate, voltage, needle gauge, needle-to-collector distance, can be optimized obtain desired morphology fibers. Although PVP commercially available molecular weights, with weight 130,000 g/mol generally considered easiest minimal challenges. However, fiber diameter this case usually micron regime, which limits utilization require diameters nano regime. Generally, lower weight, 10,000 55,000 g/mol, known present challenges preparation. In current study, optimization for possessing weights was carried out nanofibers. The electrospinning technique utilized fabrication by optimizing above-mentioned parameters. SEM analysis performed analyze morphology, quantitative correlate effect parameters on morphology. This research study will lead applications, drug encapsulation sustained release nanoparticles/nanotubes microwave absorption applications.
Язык: Английский
Процитировано
7
Journal of Manufacturing and Materials Processing, Год журнала: 2025, Номер 9(1), С. 11 - 11
Опубликована: Янв. 3, 2025
Additive manufacturing (AM) processes, such as fused deposition modelling (FDM), have emerged transformative technologies in pharmaceutical manufacturing, enabling the production of drug delivery systems with complex and customised geometries. These advancements provide precise control over release profiles facilitate development patient-specific medicines. This study investigates dissolution behaviour AM-fabricated tablets made from polyvinyl alcohol (PVA), a hydrophilic biocompatible polymer widely used systems. The influence initial mass, surface area, surface-area-to-volume ratio (S/V) on kinetics is evaluated for intricate Our findings demonstrate that these parameters, while critical conventional tablet shapes, are insufficient to fully predict Furthermore, this highlights how geometric modifications can enable administration same dosage through sustained or immediate profiles, offering enhanced versatility delivery. By leveraging design freedom provided by AM technologies, research underscores potential optimising improve therapeutic outcomes patient compliance.
Язык: Английский
Процитировано
1
Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Buspirone hydrochloride (BSP) is an anxiolytic agent approved for the management of anxiety disorders. The current US-FDA medications BSP are administered via oral route, which linked to several disadvantages such as low bioavailability and half-life necessitating multiple daily doses. For chronic diseases disorders, where long-term or lifelong often required, these factors impact patient compliance treatment adherence. present study offers alternative approach by investigating feasibility sustained transdermal delivery long-acting microneedles (MNs). Needle-tip-loaded MNs were fabricated micro-molding technique using various grades poly-vinyl alcohol (PVA) namely 4–88, 8–88, 18–88, 26–88. These compared characterization techniques Parafilm ® insertion testing, scanning electron microscopy (SEM), confocal microscopy, Fourier transform infrared spectroscopy (FTIR), histological evaluation MNs-treated human skin. effect different PVA on structural mechanical properties was evaluated. Further, in vitro release permeation tests conducted assess drug patterns across dermatomed skin over 7-day periods. highest (5507.37 ± 456.88 µg/cm 2 ) (4705.42 634.57 observed from with significant differences among based their properties. Notably, all four types crossed weekly therapeutic targets systemic BSP. Overall, this established Graphical
Язык: Английский
Процитировано
1
Polymer Bulletin, Год журнала: 2024, Номер 81(11), С. 9669 - 9697
Опубликована: Фев. 14, 2024
Язык: Английский
Процитировано
4
Polymers, Год журнала: 2024, Номер 16(20), С. 2853 - 2853
Опубликована: Окт. 10, 2024
Tissue engineering has great potential for the restoration of damaged tissue due to injury or disease. During development, scaffolds provide structural support cell growth. To grow healthy tissue, principal components such must be biocompatible and nontoxic. Poly(ε-caprolactone) (PCL) is a biopolymer that been used as key component composite applications its mechanical strength biodegradability. However, PCL alone can have low adherence wettability. Blends biomaterials incorporated achieve synergistic scaffold properties engineering. Electrospun PCL-based consist single blended-composition nanofibers with multi-layered internal architectures (i.e., core-shell nanofibers). Nanofiber diameter, composition, properties, biocompatibility, drug-loading capacity are among tunable electrospun scaffolds. Scaffold including wettability, strength, biocompatibility further enhanced layering, surface modification, coating techniques. In this article, we review nanofibrous fabrication in reported recent literature.
Язык: Английский
Процитировано
4
Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)
Опубликована: Дек. 15, 2024
Soft nano- and microfiber-based polymer scaffolds bear enormous potential for their use in cell culture tissue engineering since they mimic natural collagen structures may thus serve as biomimetic adhesive substrates. They have, however, so far been restricted to small-scale production research labs with high batch-to-batch variation. are commonly produced via electrospinning or melt electrowriting delicate nature poses obstacles detachment, storage, transportation. This study focuses on overcoming challenges the throughput practical handling, introducing new methods reproducibly prepare such suitable quantitative applications. Attention is given seamless handling transfer of samples without compromising structural integrity. Challenges detaching fibers damage well transport addressed. Cell studies demonstrate methodological advantages, emphasizing standardized testing biological readouts these fiber materials. The developed applicable across various approaches can essentially contribute utilization laboratory commercial
Язык: Английский
Процитировано
4
International Journal of Food Science & Technology, Год журнала: 2024, Номер 59(8), С. 5742 - 5753
Опубликована: Июнь 25, 2024
Summary In the storage process, meat is susceptible to external factors that produce corruption and deterioration, affecting consumers' health. Therefore, preparing an indicator membrane can detect freshness in real time, non‐destructively, visually significant. Herein, was prepared by electrostatic spinning technology using polyvinyl alcohol (PVA) as substrate curcumin (CUR) indigo (IND) mixed for detection. When were at 3:1 (w/w), CUR transformed from ketone type enol with gradual increase of pH, IND underwent electron leaps, which resulted green, brown, reddish‐brown colour changes solution, development effect effectively improved. The characterisation results showed average fibre diameter PVA/0.8 252 nm, hybrid successfully loaded nanofibres, water contact angle 103.6°, hydrophobic. addition, sensitive trimethylamine (limit detection 17.38 ppm) triethylamine 27.77 but insensitive saline, ethanol, ethyl acetate, other contaminants specificity. Finally, indicating green brown during mutton rotten, naked eye judge mutton. PVA/CUR/IND has excellent potential application real‐time non‐destructive freshness.
Язык: Английский
Процитировано
3
New Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The development of electrospun nanofibers by incorporating 2D Cr 2 CT x MXene into PVA matrices is investigated towards electrocatalytic water splitting.
Язык: Английский
Процитировано
3