Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 22, 2024
Abstract
Nano-
and
micro-fiber-based
scaffolds
bear
enormous
potential
for
their
use
in
cell
culture
tissue
engineering,
since
they
mimic
natural
collagen
structures
may
thus
serve
as
biomimetic
adhesive
substrates.
They
have,
however,
so
far
been
restricted
to
small
scale
production
research
labs
with
high
batch-to-batch
variation.
are
commonly
produced
via
electrospinning
or
melt
electro-writing
delicate
nature
poses
obstacles
detachment,
storage,
transportation.
This
study
focuses
on
overcoming
challenges
the
throughput
practical
handling,
introducing
new
methods
reproducibly
prepare
such
suitable
quantitative
applications.
Attention
is
given
seamless
handling
transfer
of
samples
without
compromising
structural
integrity.
Challenges
detaching
fibers
damage
well
transport
addressed.
Cell
studies
demonstrate
methodological
advantages,
emphasizing
standardized
testing
biological
readouts
these
fiber
materials.
The
developed
applicable
across
various
approaches
can
essentially
contribute
utilization
laboratory
commercial
Journal of Manufacturing and Materials Processing,
Journal Year:
2025,
Volume and Issue:
9(1), P. 11 - 11
Published: Jan. 3, 2025
Additive
manufacturing
(AM)
processes,
such
as
fused
deposition
modelling
(FDM),
have
emerged
transformative
technologies
in
pharmaceutical
manufacturing,
enabling
the
production
of
drug
delivery
systems
with
complex
and
customised
geometries.
These
advancements
provide
precise
control
over
release
profiles
facilitate
development
patient-specific
medicines.
This
study
investigates
dissolution
behaviour
AM-fabricated
tablets
made
from
polyvinyl
alcohol
(PVA),
a
hydrophilic
biocompatible
polymer
widely
used
systems.
The
influence
initial
mass,
surface
area,
surface-area-to-volume
ratio
(S/V)
on
kinetics
is
evaluated
for
intricate
Our
findings
demonstrate
that
these
parameters,
while
critical
conventional
tablet
shapes,
are
insufficient
to
fully
predict
Furthermore,
this
highlights
how
geometric
modifications
can
enable
administration
same
dosage
through
sustained
or
immediate
profiles,
offering
enhanced
versatility
delivery.
By
leveraging
design
freedom
provided
by
AM
technologies,
research
underscores
potential
optimising
improve
therapeutic
outcomes
patient
compliance.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1217 - 1217
Published: April 26, 2024
Polyvinylpyrrolidone
(PVP)
is
a
synthetic
polymer
that
holds
significance
in
various
fields
such
as
biomedical,
medical,
and
electronics,
due
to
its
biocompatibility
exceptional
dielectric
properties.
Electrospinning
the
most
commonly
used
tool
fabricate
fibers
because
of
convenience
wide
choice
parameter
optimization.
Various
parameters,
including
solution
molarity,
flow
rate,
voltage,
needle
gauge,
needle-to-collector
distance,
can
be
optimized
obtain
desired
morphology
fibers.
Although
PVP
commercially
available
molecular
weights,
with
weight
130,000
g/mol
generally
considered
easiest
minimal
challenges.
However,
fiber
diameter
this
case
usually
micron
regime,
which
limits
utilization
require
diameters
nano
regime.
Generally,
lower
weight,
10,000
55,000
g/mol,
known
present
challenges
preparation.
In
current
study,
optimization
for
possessing
weights
was
carried
out
nanofibers.
The
electrospinning
technique
utilized
fabrication
by
optimizing
above-mentioned
parameters.
SEM
analysis
performed
analyze
morphology,
quantitative
correlate
effect
parameters
on
morphology.
This
research
study
will
lead
applications,
drug
encapsulation
sustained
release
nanoparticles/nanotubes
microwave
absorption
applications.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 11, 2024
Wound
management
is
a
critical
aspect
of
healthcare,
necessitating
effective
and
innovative
wound
dressing
materials.
Many
existing
dressings
lack
effectiveness
exhibit
limitations,
including
poor
antimicrobial
activity,
toxicity,
inadequate
moisture
regulation,
weak
mechanical
performance.
The
aim
this
study
to
develop
natural-based
nanofibrous
structure
that
possesses
desirable
characteristics
for
use
as
dressing.
chemical
analysis
confirmed
the
successful
creation
Zein
(Ze)
(25%
w/v)
/gelatin
(Gel)
(10%
/chitosan
(CS)
(2%
/Polyvinyl
alcohol
(PVA)
scaffolds
loaded
with
vitamin
E
tocopheryl
polyethylene
glycol
succinate
(Vit
E).
swelling
percentages
nanofiber
(NF),
NF
+
Vit
E,
cross-linked
(CNF),
CNF
were
49%,
110%,
410%,
676%,
respectively;
degradation
rates
NF,
CNF,
29.57
±
5.06%,
33.78
7.8%,
14.03
7.52%,
43
6.27%,
respectively.
antibacterial
properties
demonstrated
impregnated
antibiotics
reduced
Escherichia
coli
(E.
coli)
counts
by
approximately
27–28%
Staphylococcus
aureus
(S.
aureus)
about
34–35%
compared
negative
control.
In
conclusion,
Ze/Gel/CS/PVA
have
potential
suitable
materials
because
environmentally
friendly
contribute
sustainable
care
controlled
ensures
breakdown
harmlessly.
Drug Delivery and Translational Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Buspirone
hydrochloride
(BSP)
is
an
anxiolytic
agent
approved
for
the
management
of
anxiety
disorders.
The
current
US-FDA
medications
BSP
are
administered
via
oral
route,
which
linked
to
several
disadvantages
such
as
low
bioavailability
and
half-life
necessitating
multiple
daily
doses.
For
chronic
diseases
disorders,
where
long-term
or
lifelong
often
required,
these
factors
impact
patient
compliance
treatment
adherence.
present
study
offers
alternative
approach
by
investigating
feasibility
sustained
transdermal
delivery
long-acting
microneedles
(MNs).
Needle-tip-loaded
MNs
were
fabricated
micro-molding
technique
using
various
grades
poly-vinyl
alcohol
(PVA)
namely
4–88,
8–88,
18–88,
26–88.
These
compared
characterization
techniques
Parafilm
®
insertion
testing,
scanning
electron
microscopy
(SEM),
confocal
microscopy,
Fourier
transform
infrared
spectroscopy
(FTIR),
histological
evaluation
MNs-treated
human
skin.
effect
different
PVA
on
structural
mechanical
properties
was
evaluated.
Further,
in
vitro
release
permeation
tests
conducted
assess
drug
patterns
across
dermatomed
skin
over
7-day
periods.
highest
(5507.37
±
456.88
µg/cm
2
)
(4705.42
634.57
observed
from
with
significant
differences
among
based
their
properties.
Notably,
all
four
types
crossed
weekly
therapeutic
targets
systemic
BSP.
Overall,
this
established
Graphical
European Burn Journal,
Journal Year:
2025,
Volume and Issue:
6(2), P. 18 - 18
Published: April 8, 2025
The
wound
healing
process
presents
notable
challenges
for
nursing
teams,
requiring
extensive
knowledge
of
care
materials.
A
nanoparticle-free,
bioabsorbable
pol-yvinyl
alcohol
(PVA)
with
citric
acid
(CA)
dressing
produced
by
simple
electrospin-ning
was
evaluated
to
treat
acute
in
rats.
This
PVA-CA
combination
promotes
crosslinking,
increases
the
capacity
absorption
and
confers
heal-ing
properties
due
antioxidant
action.
tested
a
quantitative
experiment
on
1.9
cm
dermatological
lesions
rats
(n
=
12),
com-paring
PVA-CA-treated
group
untreated
control
(CG).
Samples
were
collected
at
3,
7
14
days
after
lesion
induction
evaluate
inflammatory
tissue
healing.
macroscopic
histological
data
third
day
showed
similar
characteristics
both
groups;
however,
fourteen
days,
exhibited
complete
healing,
accompanied
recomposition
skin
layers,
whereas
wounds
CG
did
not
close
completely.
results
highlight
that
electrospun
PVA-AC
dressings
improve
outcomes
constitute
prom-ising
affordable
solution,
providing
suitable
environment
repair,
re-ducing
cell
infiltration,
blood
vessel
formation,
restoration
epi-thelial
tissue,
reducing
time
wounds.
