Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells DOI

Gengxu Han,

Fangshen Li,

Bin Yu

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Апрель 30, 2024

Abstract Lymphocytes are crucial to defend against harmful pathogens and sustain adaptive immunity. Developing immunomodulating materials activate lymphocytes is imperative induce effective enduring immune responses. Here, a new polymer serving as highly efficient activator of B cells reported corresponding spheres synthesized through droplet‐assisted ternary copolymerization process ascorbic acid, ethylenediamine, glyoxal. In‐depth studies conducted on the polymerization mechanisms ranging from 250 1200 nm with various surface functional groups synthesized. These prepared exhibit remarkable immunomodulatory functions correlated spheres' size groups, activations observed in vivo vitro. Through cell phagocytosis experiments RNA sequencing analysis, it proposed that selective presence CD21 membrane contribute activation cells. This work has extended realm immunological research unique perspective chemical synthesis, further substantiating fundamental application potential designing polymers.

Язык: Английский

Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases DOI
Shuoxun Zhang, Huapan Fang,

Huayu Tian

и другие.

Biomacromolecules, Год журнала: 2024, Номер 25(11), С. 7015 - 7057

Опубликована: Окт. 18, 2024

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing wide range of applications. Their unique advantages, such as rich source, good biocompatibility, excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, tissue engineering. However, conventional suffer from poor degradation

Язык: Английский

Процитировано

9

Mechanisms of tendon-bone interface healing: biomechanics, cell mechanics, and tissue engineering approaches DOI Creative Commons

Zhixiong Xu,

Wensheng Xu,

Tao Zhang

и другие.

Journal of Orthopaedic Surgery and Research, Год журнала: 2024, Номер 19(1)

Опубликована: Дек. 3, 2024

The healing of tendon-bone contact surfaces involves complex biomechanical and biochemical interactions, with pivotal implications for sports medicine rehabilitation. This review explores applications from cellular mechanics to tissue engineering, emphasizing how biomechanics impact healing. Cells regulate behavior, including growth, differentiation, migration, by sensing mechanical signals translating them into responses, which are critical in the process. Cellular modulate intracellular signaling, thereby influencing biological function capacity. Optimizing interface repair modulating extracellular environment. includes physical stimulation, such as stretching, pressure, or vibration, promote alignment enhance structural integrity. Tissue engineering focuses on designing scaffolds that mimic properties natural interface. Synthesizing these studies provides an in-depth understanding utilization principles, significantly improving offering new directions clinical treatments achieve better therapeutic outcomes rehabilitation patients injuries.

Язык: Английский

Процитировано

6

Scaffold-mediated liver regeneration: A comprehensive exploration of current advances DOI Creative Commons

Supriya Bhatt S,

J. Kumar,

Shurthi Laya

и другие.

Journal of Tissue Engineering, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

The liver coordinates over 500 biochemical processes crucial for maintaining homeostasis, detoxification, and metabolism. Its specialized cells, arranged in hexagonal lobules, enable it to function as a highly efficient metabolic engine. However, diseases such cirrhosis, fatty disease, hepatitis present significant global health challenges. Traditional drug development is expensive often ineffective at predicting human responses, driving interest advanced vitro models utilizing 3D bioprinting microfluidics. These strive mimic the liver’s complex microenvironment, improving screening disease research. Despite its resilience, vulnerable chronic illnesses, injuries, cancers, leading millions of deaths annually. Organ shortages hinder transplantation, highlighting need alternative treatments. Tissue engineering, employing polymer-based scaffolds bioprinting, shows promise. This review examines these innovative strategies, including organoids tissue-on-chip technologies, address challenges diseases.

Язык: Английский

Процитировано

5

Behavior of human gingival fibroblasts and human osteosarcoma cells on amine-gradient surfaces prepared by CPA plasma-polymerization DOI

Chang-Min Lee,

Byung‐Hoon Kim

Applied Surface Science, Год журнала: 2025, Номер 688, С. 162335 - 162335

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0

Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) DOI Creative Commons

Judit Bóvári‐Biri,

Judith A Miskei,

Zsanett Kövér

и другие.

Cells, Год журнала: 2025, Номер 14(2), С. 145 - 145

Опубликована: Янв. 20, 2025

Maxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds shown promise in addressing these challenges, regenerating this region remains complex due to its irregular shape, intricate structure, differing cellular origins compared other bones the human body. Moreover, significant variable mechanical loads placed maxillofacial add further complexity, especially cases of difficult-to-treat medical conditions. This review provides brief overview medication-related osteonecrosis jaw (MRONJ), highlighting medication-induced adverse reactions associated clinical challenges treating condition. The purpose manuscript is emphasize role biotechnology tissue engineering technologies therapy. By using scaffold materials biofactors combination with autologous cells, innovative solutions are explored for repair damaged bones. ongoing search effective that address improve vitro preparation subsequent regeneration critical. primary spotlight current research trends novel approaches area.

Язык: Английский

Процитировано

0

Emerging trends in chitosan based colloidal drug delivery systems: A translational journey from research to practice DOI

M. Manohar,

Amitha Shetty,

Cynthia Lizzie Lobo

и другие.

Carbohydrate Polymers, Год журнала: 2025, Номер 360, С. 123604 - 123604

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0

Evaluation of the Effect of Polylactic-co-Glycolic Acid Nanoparticles on the Characteristics of Stem Cells Derived from Primary Teeth DOI

Mohammad AbuOun,

Mohammad Ahmad Al-Natour,

Duaa Quedan

и другие.

Regenerative Engineering and Translational Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Язык: Английский

Процитировано

0

Microbiological and biological analysis of polymer-oxide coatings formed on dental implants enriched with clindamycin DOI Creative Commons

Hubert Knap,

Weronika Jaśko,

Weronika Maciak

и другие.

Materials Chemistry and Physics, Год журнала: 2025, Номер unknown, С. 131059 - 131059

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Innovative Bioscaffolds in Stem Cell and Regenerative Therapies for Corneal Pathologies DOI Creative Commons
F Visalli,

Federico Fava,

Matteo Capobianco

и другие.

Bioengineering, Год журнала: 2024, Номер 11(9), С. 859 - 859

Опубликована: Авг. 23, 2024

Corneal diseases, which can result in substantial visual impairment and loss of vision, are an important worldwide health issue. The aim this review was to investigate the novel application bioscaffolds stem cell regenerative treatments for treatment corneal disorders. current literature reports that organic artificial substances create imitate inherent structure cornea, facilitating attachment, growth, specialization cells. Sophisticated methods such as electrospinning, 3D bioprinting, surface modification have been reported enhance characteristics scaffold. These shown greatly improve survival cells facilitate regrowth tissue both laboratory live animal experiments. In addition, incorporation growth factors bioactive compounds within scaffolds promote a favorable milieu regeneration. To summarize, advancement these groundbreaking presents hopeful strategy regeneration has potential results individuals suffering from This study highlights possibility utilizing fields biomaterials science tackle medical demands not yet satisfied field ophthalmology.

Язык: Английский

Процитировано

1

Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold DOI

Jiyaur Rahaman,

Dhrubojyoti Mukherjee

Journal of drug targeting, Год журнала: 2024, Номер unknown, С. 1 - 31

Опубликована: Дек. 21, 2024

The occurrence of oral bone tissue degeneration and defects by osteoporosis, tooth extraction, obesity, trauma, periodontitis are major challenges for clinicians. Traditional regeneration methods often come with limitations such as donor site morbidity, limitation special shape, inflammation, resorption the implanted bone. treatment oriented biomimetic materials has achieved significant attention recently. In engineering arena, insulin gained considerable among all known biomaterials osteogenesis angiogenesis. It also exhibits osteogenic angiogenic properties interacting receptors on osteoblasts. Insulin influences remodelling both directly indirectly. acts through PI3K/Akt MAPK signalling pathways indirectly modulating RANK/RANKL/OPG pathway, which helps reduce resorption. current review reports role in cavity form scaffolds nanomaterials. Different delivery systems, utilising nanomaterials functionalised polymeric have been explored regeneration. put forward a theoretical basis future research composite

Язык: Английский

Процитировано

1