Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 30, 2024
Abstract
Lymphocytes
are
crucial
to
defend
against
harmful
pathogens
and
sustain
adaptive
immunity.
Developing
immunomodulating
materials
activate
lymphocytes
is
imperative
induce
effective
enduring
immune
responses.
Here,
a
new
polymer
serving
as
highly
efficient
activator
of
B
cells
reported
corresponding
spheres
synthesized
through
droplet‐assisted
ternary
copolymerization
process
ascorbic
acid,
ethylenediamine,
glyoxal.
In‐depth
studies
conducted
on
the
polymerization
mechanisms
ranging
from
250
1200
nm
with
various
surface
functional
groups
synthesized.
These
prepared
exhibit
remarkable
immunomodulatory
functions
correlated
spheres'
size
groups,
activations
observed
in
vivo
vitro.
Through
cell
phagocytosis
experiments
RNA
sequencing
analysis,
it
proposed
that
selective
presence
CD21
membrane
contribute
activation
cells.
This
work
has
extended
realm
immunological
research
unique
perspective
chemical
synthesis,
further
substantiating
fundamental
application
potential
designing
polymers.
Biomacromolecules,
Год журнала:
2024,
Номер
25(11), С. 7015 - 7057
Опубликована: Окт. 18, 2024
Biomedical
polymers
play
a
key
role
in
preventing,
diagnosing,
and
treating
diseases,
showcasing
wide
range
of
applications.
Their
unique
advantages,
such
as
rich
source,
good
biocompatibility,
excellent
modifiability,
make
them
ideal
biomaterials
for
drug
delivery,
biomedical
imaging,
tissue
engineering.
However,
conventional
suffer
from
poor
degradation
Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 3, 2024
The
healing
of
tendon-bone
contact
surfaces
involves
complex
biomechanical
and
biochemical
interactions,
with
pivotal
implications
for
sports
medicine
rehabilitation.
This
review
explores
applications
from
cellular
mechanics
to
tissue
engineering,
emphasizing
how
biomechanics
impact
healing.
Cells
regulate
behavior,
including
growth,
differentiation,
migration,
by
sensing
mechanical
signals
translating
them
into
responses,
which
are
critical
in
the
process.
Cellular
modulate
intracellular
signaling,
thereby
influencing
biological
function
capacity.
Optimizing
interface
repair
modulating
extracellular
environment.
includes
physical
stimulation,
such
as
stretching,
pressure,
or
vibration,
promote
alignment
enhance
structural
integrity.
Tissue
engineering
focuses
on
designing
scaffolds
that
mimic
properties
natural
interface.
Synthesizing
these
studies
provides
an
in-depth
understanding
utilization
principles,
significantly
improving
offering
new
directions
clinical
treatments
achieve
better
therapeutic
outcomes
rehabilitation
patients
injuries.
Journal of Tissue Engineering,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
The
liver
coordinates
over
500
biochemical
processes
crucial
for
maintaining
homeostasis,
detoxification,
and
metabolism.
Its
specialized
cells,
arranged
in
hexagonal
lobules,
enable
it
to
function
as
a
highly
efficient
metabolic
engine.
However,
diseases
such
cirrhosis,
fatty
disease,
hepatitis
present
significant
global
health
challenges.
Traditional
drug
development
is
expensive
often
ineffective
at
predicting
human
responses,
driving
interest
advanced
vitro
models
utilizing
3D
bioprinting
microfluidics.
These
strive
mimic
the
liver’s
complex
microenvironment,
improving
screening
disease
research.
Despite
its
resilience,
vulnerable
chronic
illnesses,
injuries,
cancers,
leading
millions
of
deaths
annually.
Organ
shortages
hinder
transplantation,
highlighting
need
alternative
treatments.
Tissue
engineering,
employing
polymer-based
scaffolds
bioprinting,
shows
promise.
This
review
examines
these
innovative
strategies,
including
organoids
tissue-on-chip
technologies,
address
challenges
diseases.
Cells,
Год журнала:
2025,
Номер
14(2), С. 145 - 145
Опубликована: Янв. 20, 2025
Maxillofacial
bone
defects
can
have
a
profound
impact
on
both
facial
function
and
aesthetics.
While
various
biomaterial
scaffolds
shown
promise
in
addressing
these
challenges,
regenerating
this
region
remains
complex
due
to
its
irregular
shape,
intricate
structure,
differing
cellular
origins
compared
other
bones
the
human
body.
Moreover,
significant
variable
mechanical
loads
placed
maxillofacial
add
further
complexity,
especially
cases
of
difficult-to-treat
medical
conditions.
This
review
provides
brief
overview
medication-related
osteonecrosis
jaw
(MRONJ),
highlighting
medication-induced
adverse
reactions
associated
clinical
challenges
treating
condition.
The
purpose
manuscript
is
emphasize
role
biotechnology
tissue
engineering
technologies
therapy.
By
using
scaffold
materials
biofactors
combination
with
autologous
cells,
innovative
solutions
are
explored
for
repair
damaged
bones.
ongoing
search
effective
that
address
improve
vitro
preparation
subsequent
regeneration
critical.
primary
spotlight
current
research
trends
novel
approaches
area.
Bioengineering,
Год журнала:
2024,
Номер
11(9), С. 859 - 859
Опубликована: Авг. 23, 2024
Corneal
diseases,
which
can
result
in
substantial
visual
impairment
and
loss
of
vision,
are
an
important
worldwide
health
issue.
The
aim
this
review
was
to
investigate
the
novel
application
bioscaffolds
stem
cell
regenerative
treatments
for
treatment
corneal
disorders.
current
literature
reports
that
organic
artificial
substances
create
imitate
inherent
structure
cornea,
facilitating
attachment,
growth,
specialization
cells.
Sophisticated
methods
such
as
electrospinning,
3D
bioprinting,
surface
modification
have
been
reported
enhance
characteristics
scaffold.
These
shown
greatly
improve
survival
cells
facilitate
regrowth
tissue
both
laboratory
live
animal
experiments.
In
addition,
incorporation
growth
factors
bioactive
compounds
within
scaffolds
promote
a
favorable
milieu
regeneration.
To
summarize,
advancement
these
groundbreaking
presents
hopeful
strategy
regeneration
has
potential
results
individuals
suffering
from
This
study
highlights
possibility
utilizing
fields
biomaterials
science
tackle
medical
demands
not
yet
satisfied
field
ophthalmology.
Journal of drug targeting,
Год журнала:
2024,
Номер
unknown, С. 1 - 31
Опубликована: Дек. 21, 2024
The
occurrence
of
oral
bone
tissue
degeneration
and
defects
by
osteoporosis,
tooth
extraction,
obesity,
trauma,
periodontitis
are
major
challenges
for
clinicians.
Traditional
regeneration
methods
often
come
with
limitations
such
as
donor
site
morbidity,
limitation
special
shape,
inflammation,
resorption
the
implanted
bone.
treatment
oriented
biomimetic
materials
has
achieved
significant
attention
recently.
In
engineering
arena,
insulin
gained
considerable
among
all
known
biomaterials
osteogenesis
angiogenesis.
It
also
exhibits
osteogenic
angiogenic
properties
interacting
receptors
on
osteoblasts.
Insulin
influences
remodelling
both
directly
indirectly.
acts
through
PI3K/Akt
MAPK
signalling
pathways
indirectly
modulating
RANK/RANKL/OPG
pathway,
which
helps
reduce
resorption.
current
review
reports
role
in
cavity
form
scaffolds
nanomaterials.
Different
delivery
systems,
utilising
nanomaterials
functionalised
polymeric
have
been
explored
regeneration.
put
forward
a
theoretical
basis
future
research
composite
