Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7015 - 7057

Published: Oct. 18, 2024

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing wide range of applications. Their unique advantages, such as rich source, good biocompatibility, excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, tissue engineering. However, conventional suffer from poor degradation

Language: Английский

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Scaffold-mediated liver regeneration: A comprehensive exploration of current advances

Journal of Tissue Engineering, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

The liver coordinates over 500 biochemical processes crucial for maintaining homeostasis, detoxification, and metabolism. Its specialized cells, arranged in hexagonal lobules, enable it to function as a highly efficient metabolic engine. However, diseases such cirrhosis, fatty disease, hepatitis present significant global health challenges. Traditional drug development is expensive often ineffective at predicting human responses, driving interest advanced vitro models utilizing 3D bioprinting microfluidics. These strive mimic the liver’s complex microenvironment, improving screening disease research. Despite its resilience, vulnerable chronic illnesses, injuries, cancers, leading millions of deaths annually. Organ shortages hinder transplantation, highlighting need alternative treatments. Tissue engineering, employing polymer-based scaffolds bioprinting, shows promise. This review examines these innovative strategies, including organoids tissue-on-chip technologies, address challenges diseases.

Language: Английский

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Mechanisms of tendon-bone interface healing: biomechanics, cell mechanics, and tissue engineering approaches

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 3, 2024

The healing of tendon-bone contact surfaces involves complex biomechanical and biochemical interactions, with pivotal implications for sports medicine rehabilitation. This review explores applications from cellular mechanics to tissue engineering, emphasizing how biomechanics impact healing. Cells regulate behavior, including growth, differentiation, migration, by sensing mechanical signals translating them into responses, which are critical in the process. Cellular modulate intracellular signaling, thereby influencing biological function capacity. Optimizing interface repair modulating extracellular environment. includes physical stimulation, such as stretching, pressure, or vibration, promote alignment enhance structural integrity. Tissue engineering focuses on designing scaffolds that mimic properties natural interface. Synthesizing these studies provides an in-depth understanding utilization principles, significantly improving offering new directions clinical treatments achieve better therapeutic outcomes rehabilitation patients injuries.

Language: Английский

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Behavior of human gingival fibroblasts and human osteosarcoma cells on amine-gradient surfaces prepared by CPA plasma-polymerization

Applied Surface Science, Journal Year: 2025, Volume and Issue: 688, P. 162335 - 162335

Published: Jan. 11, 2025

Language: Английский

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Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ)

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 145 - 145

Published: Jan. 20, 2025

Maxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds shown promise in addressing these challenges, regenerating this region remains complex due to its irregular shape, intricate structure, differing cellular origins compared other bones the human body. Moreover, significant variable mechanical loads placed maxillofacial add further complexity, especially cases of difficult-to-treat medical conditions. This review provides brief overview medication-related osteonecrosis jaw (MRONJ), highlighting medication-induced adverse reactions associated clinical challenges treating condition. The purpose manuscript is emphasize role biotechnology tissue engineering technologies therapy. By using scaffold materials biofactors combination with autologous cells, innovative solutions are explored for repair damaged bones. ongoing search effective that address improve vitro preparation subsequent regeneration critical. primary spotlight current research trends novel approaches area.

Language: Английский

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Emerging trends in chitosan based colloidal drug delivery systems: A translational journey from research to practice

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123604 - 123604

Published: April 1, 2025

Language: Английский

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Innovative Bioscaffolds in Stem Cell and Regenerative Therapies for Corneal Pathologies

Bioengineering, Journal Year: 2024, Volume and Issue: 11(9), P. 859 - 859

Published: Aug. 23, 2024

Corneal diseases, which can result in substantial visual impairment and loss of vision, are an important worldwide health issue. The aim this review was to investigate the novel application bioscaffolds stem cell regenerative treatments for treatment corneal disorders. current literature reports that organic artificial substances create imitate inherent structure cornea, facilitating attachment, growth, specialization cells. Sophisticated methods such as electrospinning, 3D bioprinting, surface modification have been reported enhance characteristics scaffold. These shown greatly improve survival cells facilitate regrowth tissue both laboratory live animal experiments. In addition, incorporation growth factors bioactive compounds within scaffolds promote a favorable milieu regeneration. To summarize, advancement these groundbreaking presents hopeful strategy regeneration has potential results individuals suffering from This study highlights possibility utilizing fields biomaterials science tackle medical demands not yet satisfied field ophthalmology.

Language: Английский

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Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Abstract Lymphocytes are crucial to defend against harmful pathogens and sustain adaptive immunity. Developing immunomodulating materials activate lymphocytes is imperative induce effective enduring immune responses. Here, a new polymer serving as highly efficient activator of B cells reported corresponding spheres synthesized through droplet‐assisted ternary copolymerization process ascorbic acid, ethylenediamine, glyoxal. In‐depth studies conducted on the polymerization mechanisms ranging from 250 1200 nm with various surface functional groups synthesized. These prepared exhibit remarkable immunomodulatory functions correlated spheres' size groups, activations observed in vivo vitro. Through cell phagocytosis experiments RNA sequencing analysis, it proposed that selective presence CD21 membrane contribute activation cells. This work has extended realm immunological research unique perspective chemical synthesis, further substantiating fundamental application potential designing polymers.

Language: Английский

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Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Dec. 21, 2024

The occurrence of oral bone tissue degeneration and defects by osteoporosis, tooth extraction, obesity, trauma, periodontitis are major challenges for clinicians. Traditional regeneration methods often come with limitations such as donor site morbidity, limitation special shape, inflammation, resorption the implanted bone. treatment oriented biomimetic materials has achieved significant attention recently. In engineering arena, insulin gained considerable among all known biomaterials osteogenesis angiogenesis. It also exhibits osteogenic angiogenic properties interacting receptors on osteoblasts. Insulin influences remodelling both directly indirectly. acts through PI3K/Akt MAPK signalling pathways indirectly modulating RANK/RANKL/OPG pathway, which helps reduce resorption. current review reports role in cavity form scaffolds nanomaterials. Different delivery systems, utilising nanomaterials functionalised polymeric have been explored regeneration. put forward a theoretical basis future research composite

Language: Английский

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