Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
296, С. 139663 - 139663
Опубликована: Янв. 8, 2025
Язык: Английский
Electrospinning Using AC Electric Fields
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
Abstract
Electrospinning
is
increasingly
used
as
a
staple
technology
for
the
fabrication
of
nano‐
and
micro‐fibers
different
materials.
Most
processes
utilize
direct
current
(DC)
electrospinning,
multitude
DC‐electrospinning
tools
ranging
from
research
to
commercial
production
systems
currently
available.
Yet,
there
are
numerous
studies
performed
on
electrospinning
techniques
utilizing
non‐DC,
periodic
electric
fields,
or
alternating
(AC)
electrospinning.
Those
demonstrate
strong
potential
AC‐electrospinning
sustainable
various
nanofibrous
materials
structures.
Although
tremendous
progress
achieved
in
development
over
last
10
years,
this
technique
remains
uncommon.
This
paper
reviews
concepts,
instrumentation,
technology.
The
main
focus
review
most
studied,
“electric
wind”
driven
tentatively
named
field
(AFES).
latter
term
emphasizes
role
AC
field's
confinement
fiber‐generating
electrode
absence
counter
such
an
system.
synopses
AFES
process
parameters,
spinneret
designs,
benefits
obstacles,
advancements
electrospun
nano/micro‐fibrous
materials/structures
their
applications
given,
future
directions
discussed.
Язык: Английский
Transparent and Mechanically Robust Janus Nanofiber Membranes for Open Wound Healing and Monitoring
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(46), С. 63389 - 63403
Опубликована: Ноя. 7, 2024
The
electrospun
nanofiber
membrane
has
demonstrated
great
potential
for
wound
management
due
to
its
porous
structure,
large
surface
area,
mechanical
strength,
and
barrier
properties.
However,
there
is
a
need
develop
transparent
bioactive
nanofibers
with
strong
properties
facilitate
the
monitoring
of
healing
process.
In
this
study,
we
present
an
electrospinning-based
method
creating
(∼80–90%),
(∼11–13
MPa),
Janus
membranes.
innovative
square
pattern
architecture
includes
thin
hydrophobic
polycaprolactone
layer
on
top
hydrophilic
ethylene-vinyl
alcohol
nanofiber,
which
enables
absorption
excess
biofluid
from
exhibits
wettability
water.
Furthermore,
incorporating
5%
chitosan
into
composition
accelerates
process
through
antioxidant
antimicrobial
activity
against
various
bacteria,
including
drug-resistant
strains.
developed
also
demonstrates
skin-repairing
function,
quick
blood
clotting
(around
145
±
12
s),
biocompatibility
keratinocyte
(≥90%),
as
well
in
vitro
cell
migration
(∼24
h).
With
tensile
strength
11–13
MPa,
effectively
adheres
knee
joint
even
after
running
4
km.
These
optimal
make
it
suitable
effective
inspection
process,
without
frequent
dressing
changes.
Язык: Английский
Advancements in Characterization and Preclinical Applications of Hyaluronic Acid-Based Biomaterials for Wound Healing: A Review
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2025,
Номер
unknown, С. 100706 - 100706
Опубликована: Фев. 1, 2025
Язык: Английский
Thermally Stabilised Poly(vinyl alcohol) Nanofibrous Materials Produced by Scalable Electrospinning: Applications in Tissue Engineering
Polymers,
Год журнала:
2024,
Номер
16(14), С. 2079 - 2079
Опубликована: Июль 21, 2024
Electrospinning
is
a
widely
employed
manufacturing
platform
for
tissue
engineering
applications
because
it
produces
structures
that
closely
mimic
the
extracellular
matrix.
Herein,
we
demonstrate
potential
of
poly(vinyl
alcohol)
(PVA)
electrospun
nanofibers
as
scaffolds
engineering.
Nanofibers
were
created
by
needleless
direct
current
electrospinning
from
PVA
with
two
different
degrees
hydrolysis
(DH),
namely
98%
and
99%
subsequently
heat
treated
at
180
°C
up
to
16
h
render
them
insoluble
in
aqueous
environments
without
use
toxic
cross-linking
agents.
Despite
small
differences
chemical
structure,
changes
material
properties
substantial.
The
higher
degree
resulted
non-woven
supports
thinner
fibres
(285
±
81
nm
c.f.
399
153
nm)
mechanically
stronger
62%
(±11%)
almost
twice
more
crystalline
than
those
hydrolysed
PVA.
Although
prolonged
treatment
(16
h)
did
not
influence
fibre
morphology,
reduced
crystallinity
tensile
strength
both
sets
materials.
All
samples
demonstrated
lack
or
very
low
haemolysis
(<5%),
there
no
notable
their
anticoagulant
activity
(≤3%).
Thrombus
formation,
on
other
hand,
increased
82%
(±18%)
71%
(±10%)
samples,
h,
consequence
preservation
fibrous
morphology.
3T3
mouse
fibroblasts
showed
best
proliferation
thermally
stabilised
4
8
h.
Overall
these
show
'greener'
alternatives
materials,
especially
cases
where
they
may
be
used
delivery
vectors
tolerant
additives.
Язык: Английский
Functional poly(e-caprolactone)/SerMA hybrid dressings with dimethyloxalylglycine-releasing property improve cutaneous wound healing
Biomedical Materials,
Год журнала:
2024,
Номер
19(6), С. 065011 - 065011
Опубликована: Авг. 29, 2024
Abstract
Medical
dressings
with
multifunctional
properties,
including
potent
regeneration
capability
and
good
biocompatibility,
are
increasingly
needed
in
clinical
practice.
In
this
study,
we
reported
a
novel
hybrid
wound
dressing
(PCL/SerMA/DMOG)
that
combines
electrospun
PCL
membranes
DMOG-loaded
methacrylated
sericin
(SerMA)
hydrogel.
such
design,
DMOG
molecules
released
from
the
sustained
manner
vitro
.
A
series
of
assays
demonstrated
has
multiple
biological
functions,
promotion
human
umbilical
vein
endothelial
cells
proliferation
migration,
vascularization,
generation
intracellular
NO.
When
applied
to
cutaneous
wound,
PCL/SerMA/DMOG
significantly
accelerated
closure
tissue
by
promoting
angiogenesis
area,
collagen
deposition,
cell
within
bed.
These
results
highlight
potential
application
as
promising
alternatives
for
accelerating
healing
via
improved
biocompatibility
amelioration.
Язык: Английский
Industrial-scale needle-less electrospinning of tetracycline-immobilized nanofibrous scaffolds using a polycaprolactone/polyethylene oxide/chitosan blend for wound healing
Journal of Industrial Textiles,
Год журнала:
2024,
Номер
54
Опубликована: Янв. 1, 2024
Nanofibrous
scaffolds
offer
significant
promise
for
wound
healing
due
to
their
ability
absorb
exudates,
prevent
microbial
contamination,
and
enhance
oxygen
diffusion.
However,
challenges
remain
in
fully
realizing
clinical
potential,
as
previous
research
has
primarily
focused
on
made
of
two
polymers
or
those
encapsulating
therapeutic
agents
within
nanofibers.
Additionally,
scaling
up
fabrication
while
maintaining
functionality
presents
a
challenge.
This
study
introduces
novel
type
nanofibrous
scaffold,
combining
poly
(ethylene
oxide)
(PEO),
(caprolactone)
(PCL),
chitosan
(CS)
various
mass
ratios,
electrospun
using
Nanospider™
technology.
The
featured
fiber
diameters
ranging
from
134
±
37
148
38
nm
exhibit
high
gram-per-square-meter
values
between
6.8
8.6
g/m
2
.
An
optimal
balance
hydrophilicity
was
achieved,
the
demonstrated
superior
breathability
with
moisture
vapor
transmission
rates
1904.3
28.6
2005.7
42.9
/day,
outperforming
commercial
dressings.
wide
range
hydrolytic
degradation
(3.8
1%
73.2
0.8%),
elongation
at
fracture
(21%
Young’s
modulus
(106.7
8.5
MPa
170.7
11.9
MPa)
were
observed.
Surface-immobilized
tetracycline
(TET)
significantly
enhanced
antibacterial
efficacy,
inhibition
zones
exceeding
20
mm
against
Escherichia
coli.
Our
findings
confirm
that
scaffold
properties
can
be
effectively
tailored
by
adjusting
PEO/PCL
ratio,
advancing
customization
care.
Post-fabrication
soaking
TET
solutions
further
boosts
performance
allows
post-production
adjustments.
Compared
existing
studies,
this
approach
simplifies
improves
practicality
care
solutions.
Язык: Английский