Polymers,
Год журнала:
2025,
Номер
17(11), С. 1520 - 1520
Опубликована: Май 29, 2025
Current
hydrogels
used
for
cartilage
tissue
engineering
often
lack
the
mechanical
strength
and
structural
integrity
required
to
mimic
native
human
cartilage.
This
study
addresses
this
limitation
by
developing
reinforced
based
on
a
ternary
polymer
blend
of
poly(vinyl)
alcohol
(PVA),
gelatin
(GL),
chitosan
(CH),
with
gentamicin
sulfate
(GS)
as
an
antimicrobial
agent
crosslinker.
The
were
produced
using
two
crosslinking
methods,
freeze/thaw
heated
cycles,
forcespun
polycaprolactone
(PCL)
nanofiber
improve
performance.
Chemical
characterization
revealed
that
GS
forms
weak
hydrogen
bonds
polymers,
leading
esterification
PVA,
covalent
are
formed
result
free
amino
group
(-NH2)
reacts
carboxylic
acid
(-COOH)
gelatin.
SEM
images
help
us
see
how
fibers
via
force
spinning
technology,
while
properties
evaluated
uniaxial
tensile
compressive
tests.
Water
retention
measurements
performed
examine
process’s
influence
hydrogel’s
water
retention,
hydrogel
surface
roughness
was
obtained
confocal
microscopy
images.
A
constitutive
model
non-Gaussian
strain
energy
density
introduced
predict
experimental
behavior
data
hydrogel,
considering
non-monotonous
softening
function.
Loading
unloading
tests
demonstrated
enhanced
without
compromising
or
biocompatibility
because
reaction
between
CH
PCL-reinforced
PVA/GL/CH
shows
strong
potential
repair
applications.
Journal of Composites Science,
Год журнала:
2025,
Номер
9(3), С. 133 - 133
Опубликована: Март 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
There
is
ongoing
research
for
biomedical
applications
of
polyvinyl
alcohol
(PVA)-based
hydrogels;
however,
the
execution
this
has
not
yet
been
achieved
at
an
appropriate
level
commercialization.
Advanced
perception
necessary
design
and
synthesis
suitable
materials,
such
as
PVA-based
hydrogel
applications.
Among
polymers,
drawn
great
interest
in
owing
to
their
attractive
potential
with
characteristics
good
biocompatibility,
mechanical
strength,
apposite
water
content.
By
designing
approach
investigating
structure,
hydrogels
can
attain
superb
cytocompatibility,
flexibility,
antimicrobial
activities,
signifying
that
it
a
candidate
tissue
engineering
regenerative
medicine,
drug
delivery,
wound
dressing,
contact
lenses,
other
fields.
In
review,
we
highlight
current
progresses
on
explaining
diverse
usage
across
variety
areas.
We
explain
numerous
techniques
related
phenomena
based
these
materials.
This
review
may
stipulate
wide
reference
future
acumens
materials
extensive
Gels,
Год журнала:
2024,
Номер
10(11), С. 693 - 693
Опубликована: Окт. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
Protein-based
hydrogels
with
stretchability
and
conductivity
have
potential
applications
in
wearable
electronic
devices.
However,
the
development
of
protein-based
biocomposite
is
still
limited.
In
this
work,
we
used
natural
ferritin
to
develop
a
PVA/ferritin
hydrogel
by
repetitive
freeze–thaw
method.
hydrogel,
ferritin,
as
nano
spring,
forms
hydrogen
bond
PVA
networks,
which
reduces
crystallinity
significantly
improves
hydrogel.
The
fracture
strain
203%,
stress
112.2
kPa.
toughness
enhanced
147.03
kJ/m3,
more
than
3
times
that
(39.17
kJ/m3).
addition,
free
residues
iron
ions
endow
ionic
(0.15
S/m).
sensor
constructed
from
shows
good
sensitivity
(gauge
factor
=
1.7
at
150%
strain),
accurate
real-time
resistance
response,
long
cyclic
working
stability
when
for
joint
motion
monitoring.
results
indicate
prepared
facile
method
has
flexible
sensors.
This
work
develops
new
preparation
Gels,
Год журнала:
2025,
Номер
11(3), С. 168 - 168
Опубликована: Фев. 26, 2025
Materials
with
antimicrobial
properties
and
high
adsorption
capabilities
are
crucial
for
managing
exudate
in
post-surgical
cases.
However,
achieving
both
simultaneously
remains
a
challenge.
In
this
study,
we
first
synthesized
curcumin-loaded
organosolv
lignin
nanoparticles
(Lig-Cur
Nps)
using
solvent-shifting
approach
continuous
flow
reactor.
These
Lig-Cur
NPs
were
then
dispersed
polyvinyl
alcohol
(PVA)
solution.
The
PVA-Lig-Cur
NP
colloidal
suspension
was
further
crosslinked
tannic
acid
(TA)
through
hydrogen
bonding
interactions.
A
simple
freeze–thaw
cycle
of
the
TA
resulted
formation
stable
gel,
which
lyophilized
to
fabricate
PVA-Lig-Cur-TA
hydrogel
scaffold.
This
scaffold
features
an
interconnected
microporous
network
swelling
percentage
800%,
enabling
rapid
exudates.
Its
excellent
efficacy
against
Staphylococcus
aureus,
bacterium
commonly
found
on
skin,
Pseudomonas
aeruginosa
highlight
its
potential
effectively
remove
exudates
while
preventing
bacterial
colonization.
