The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders
Molecules,
Год журнала:
2025,
Номер
30(4), С. 848 - 848
Опубликована: Фев. 12, 2025
Among
neurotrophins,
including
nerve
growth
factor
(NGF),
brain-derived
neurotrophic
(BDNF),
neurotrophin-3
(NT-3),
and
neurotrophin-4
(NT-4/5),
BDNF
has
been
extensively
studied
for
its
physiological
role
in
cell
survival
synaptic
regulation
the
central
nervous
system's
(CNS's)
neurons.
binds
to
TrkB
(a
tyrosine
kinase)
with
high
affinity,
resulting
downstream
intracellular
signaling
cascades
play
crucial
roles
determining
fate,
neuronal
differentiation
maturation
of
CNS
It
well
demonstrated
that
downregulation/dysregulation
BDNF/TrkB
system
is
implicated
pathogenesis
neurologic
psychiatric
disorders,
such
as
Alzheimer's
disease
(AD)
depression.
Interestingly,
effects
mimetic
compounds
flavonoids,
small
molecules
which
can
activate
TrkB-mediated
signaling,
have
investigated
potential
therapeutic
strategies
brain
diseases,
given
p75NTR,
a
common
neurotrophin
receptor,
also
contributes
death
under
variety
pathological
conditions
neurodegeneration.
Since
downregulation
associated
pathophysiology
neurodegenerative
diseases
understanding
how
alterations
contribute
progression
could
provide
valuable
insight
prevention
these
diseases.
The
present
review
shows
recent
advances
molecular
mechanisms
underlying
plasticity,
providing
critical
insights
into
impact
mimetics
Язык: Английский
Study on the ameliorative effect of marine fungus Hansfordia sinuosae extracellular polysaccharide on DSS-induced ulcerative colitis and depression-like behavior
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142852 - 142852
Опубликована: Апрель 1, 2025
Язык: Английский
The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases—Therapeutic Approaches: A Comprehensive Review
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10041 - 10041
Опубликована: Сен. 18, 2024
The
objective
of
this
review
is
to
provide
a
comprehensive
examination
the
role
microbial
metabolites
in
progression
neurodegenerative
diseases,
as
well
investigate
potential
therapeutic
interventions
targeting
microbiota.
A
literature
search
was
conducted
across
following
databases:
PubMed,
Scopus,
Web
Science,
ScienceDirect,
and
Wiley.
Key
terms
related
gut
microbiota,
metabolites,
specific
metabolic
products
were
used.
included
both
preclinical
clinical
research
articles
published
between
2000
2024.
Short-chain
fatty
acids
have
been
demonstrated
play
crucial
modulating
neuroinflammation,
preserving
integrity
blood–brain
barrier,
influencing
neuronal
plasticity
protection.
Furthermore,
amino
their
derivatives
exert
significant
influence
on
CNS
function.
These
impact
health
by
regulating
intestinal
permeability,
immune
responses,
directly
neuroinflammation
oxidative
stress,
which
are
integral
diseases.
Therapeutic
strategies,
including
prebiotics,
probiotics,
dietary
modifications,
fecal
microbiota
transplantation
confirmed
restore
balance
enhance
production
neuroprotective
metabolites.
novel
drug
developments
based
present
promising
avenues.
its
represent
field
with
advance
our
understanding
develop
treatments
for
Язык: Английский