Enhanced localized pressure-mediated non-viral gene delivery
Drug Delivery and Translational Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
Topically
applied
therapies
must
not
only
be
effective
at
the
molecular
level
but
also
efficiently
access
target
site
which
can
on
milli/centimetre-scales.
This
bottleneck
is
particularly
inhibitory
for
peptide
and
nucleic
acid
macromolecule
drug
delivery
strategies,
especially
when
aiming
to
wounded,
infected,
poorly
perfused
tissues
of
significant
volume
geometry.
Methods
drive
fluid-flow
or
enhance
physical
distribution
such
formulations
after
local
administration
in
accessible
(skin,
eye,
intestine)
would
transformative
realizing
potential
therapeutics.
We
previously
developed
a
technology
termed
G
lycosaminoglycan
(GAG)-binding
e
nhanced
t
ransduction
(GET)
deliver
variety
cargoes
intracellularly,
using
GAG-binding
peptides
cell
penetrating
(CPPs)
form
nanoparticles.
Herein,
we
demonstrate
that
most
simplistic
GET
formulation
relatively
poor
diffusing
into
tissue
matrix
(tested
collagen
scaffolds).
Changing
nanoparticle
physicochemical
properties
penetration,
however
use
pressure
differential,
generating
significantly
enhances
gene
over
milli/centimetre
scales.
adapted
clinically
used
systems
administer
both
negative
(Negative
(NP)
wound
therapy;
NPWT)
positive
pressures
(PP;
Insufflator).
Pressure
differences
generated
enhanced
distribution,
were
able
show
first-time
localized
transfer
vitro
scaffolds
transfection
ex
vivo
skin
explants.
The
ability
simply
control
intra-tissue
localization
scales
application
will
facilitate
new
strategies
tissues.
Importantly
site-specific
enhancement
penetration
activity
novel
nanotechnologies
therapeutics
could
future
regenerative
medicine
strategies.
Graphical
Язык: Английский
Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
development
of
bioink-based
3D-printed
scaffolds
has
revolutionized
bone
tissue
engineering
(BTE)
by
enabling
patient-specific
and
biomimetic
constructs
for
regeneration.
Язык: Английский
Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 5, 2024
Periodontal
disease
(PD)
is
a
chronic
inflammatory
condition
that
affects
the
teeth
and
their
supporting
tissues,
ultimately
culminating
in
tooth
loss.
Currently,
treatment
modalities,
such
as
systemic
local
administration
of
antibiotics,
serve
to
mitigate
progression
inflammation
yet
fall
short
restoring
original
anatomical
structure
physiological
function
periodontal
tissues.
Biocompatible
material-based
tissue
engineering
seems
be
promising
therapeutic
strategy
for
treating
PD.
Collagen,
component
extracellular
matrix
commonly
used
engineering,
has
been
regarded
biogenic
material
regeneration
owing
its
high
cell-activating
biocompatible
properties.
The
structural
chemical
similarities
between
collagen
components
oral
render
it
candidate
dental
regeneration.
This
review
explored
properties
current
applications
We
also
discussed
recent
therapies
preparation
techniques.
scrutinizes
pros
cons
associated
with
application
collagen-based
biomaterials
PD
treatment,
aiming
pave
way
future
management
Язык: Английский
Embracing the future: The application of regenerative biomaterials in the spinal disorders
Biomedical Technology,
Год журнала:
2024,
Номер
9, С. 100068 - 100068
Опубликована: Дек. 25, 2024
Язык: Английский
Biomaterials for Corneal Regeneration
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Abstract
Corneal
blindness
is
a
significant
reason
for
visual
impairment
globally.
Researchers
have
been
investigating
several
methods
corneal
regeneration
in
order
to
cure
these
patients.
Biomaterials
are
favored
due
their
biocompatibility
and
capacity
promote
cell
adhesion.
A
variety
of
natural
synthetic
biomaterials,
along
with
decellularized
cornea,
employed
wound
healing.
Commonly
utilized
biomaterials
encompass
proteins
such
as
collagen,
gelatin,
silk
fibroin
(SF),
well
polysaccharides
including
alginate,
chitosan
(CS),
hyaluronic
acid
(HA),
cellulose.
Synthetic
primarily
consist
polyvinyl
alcohol
(PVA),
poly(ε‐caprolactone)
(PCL),
poly
(lactic‐co‐glycolic
acid)
(PLGA).
Bio‐based
materials
composites
hydrogels,
films,
scaffolds,
patches,
nanocapsules,
other
formats
the
treatment
blinding
ocular
conditions,
wounds,
ulcers,
endothelium,
stromal
defects.
This
review
attempts
summarize
vitro,
preclinical,
clinical
trial
studies
relevant
using
within
last
five
years,
expect
that
experiences
outcomes
will
inspire
provide
practical
strategies
future
development
regeneration.
Furthermore,
potential
improvements
difficulties
discussed.
Язык: Английский
Collagen-based materials in male genitourinary diseases and tissue regeneration
Deleted Journal,
Год журнала:
2024,
Номер
6(1)
Опубликована: Дек. 1, 2024
Abstract
Male
genitourinary
dysfunction
causes
serious
physical
or
mental
distress,
such
as
infertility
and
psychological
harm,
which
leads
to
impaired
quality
of
life.
Current
conventional
treatments
involving
drug
therapy,
surgical
repair,
tissue
grafting
have
a
limited
effect
on
recovering
the
function
fertility
organs.
To
address
these
limitations,
various
biomaterials
been
explored,
with
collagen-based
materials
increasingly
gaining
attention
for
reconstructing
male
system
due
their
superior
biocompatibility,
biodegradability,
low
antigenicity,
biomimetic
3D
matrix
characteristics,
hemostatic
efficacy,
regeneration
capabilities.
This
review
covers
recent
biomedical
applications
including
treatment
erectile
dysfunction,
premature
ejaculation,
penile
girth
enlargement,
prostate
cancer,
Peyronie's
disease,
chronic
kidney
etc.
Although
there
are
relatively
few
clinical
trials,
promising
results
existing
studies
animal
models
reveal
bright
future
in
diseases.
Graphic
Язык: Английский