Collagen-based materials in male genitourinary diseases and tissue regeneration DOI Creative Commons
Fangyuan Li,

XinHuang,

Ruiying Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 1, 2024

Abstract Male genitourinary dysfunction causes serious physical or mental distress, such as infertility and psychological harm, which leads to impaired quality of life. Current conventional treatments involving drug therapy, surgical repair, tissue grafting have a limited effect on recovering the function fertility organs. To address these limitations, various biomaterials been explored, with collagen-based materials increasingly gaining attention for reconstructing male system due their superior biocompatibility, biodegradability, low antigenicity, biomimetic 3D matrix characteristics, hemostatic efficacy, regeneration capabilities. This review covers recent biomedical applications including treatment erectile dysfunction, premature ejaculation, penile girth enlargement, prostate cancer, Peyronie's disease, chronic kidney etc. Although there are relatively few clinical trials, promising results existing studies animal models reveal bright future in diseases. Graphic

Language: Английский

Biomaterials for Corneal Regeneration DOI Creative Commons
Yimeng Li, Zhengke Wang

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Corneal blindness is a significant reason for visual impairment globally. Researchers have been investigating several methods corneal regeneration in order to cure these patients. Biomaterials are favored due their biocompatibility and capacity promote cell adhesion. A variety of natural synthetic biomaterials, along with decellularized cornea, employed wound healing. Commonly utilized biomaterials encompass proteins such as collagen, gelatin, silk fibroin (SF), well polysaccharides including alginate, chitosan (CS), hyaluronic acid (HA), cellulose. Synthetic primarily consist polyvinyl alcohol (PVA), poly(ε‐caprolactone) (PCL), poly (lactic‐co‐glycolic acid) (PLGA). Bio‐based materials composites hydrogels, films, scaffolds, patches, nanocapsules, other formats the treatment blinding ocular conditions, wounds, ulcers, endothelium, stromal defects. This review attempts summarize vitro, preclinical, clinical trial studies relevant using within last five years, expect that experiences outcomes will inspire provide practical strategies future development regeneration. Furthermore, potential improvements difficulties discussed.

Language: Английский

Citations

4
Enhanced localized pressure-mediated non-viral gene delivery DOI Creative Commons
James E. Dixon,

Vanessa Wellington,

Alaa Elnima

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Topically applied therapies must not only be effective at the molecular level but also efficiently access target site which can on milli/centimetre-scales. This bottleneck is particularly inhibitory for peptide and nucleic acid macromolecule drug delivery strategies, especially when aiming to wounded, infected, poorly perfused tissues of significant volume geometry. Methods drive fluid-flow or enhance physical distribution such formulations after local administration in accessible (skin, eye, intestine) would transformative realizing potential therapeutics. We previously developed a technology termed G lycosaminoglycan (GAG)-binding e nhanced t ransduction (GET) deliver variety cargoes intracellularly, using GAG-binding peptides cell penetrating (CPPs) form nanoparticles. Herein, we demonstrate that most simplistic GET formulation relatively poor diffusing into tissue matrix (tested collagen scaffolds). Changing nanoparticle physicochemical properties penetration, however use pressure differential, generating significantly enhances gene over milli/centimetre scales. adapted clinically used systems administer both negative (Negative (NP) wound therapy; NPWT) positive pressures (PP; Insufflator). Pressure differences generated enhanced distribution, were able show first-time localized transfer vitro scaffolds transfection ex vivo skin explants. The ability simply control intra-tissue localization scales application will facilitate new strategies tissues. Importantly site-specific enhancement penetration activity novel nanotechnologies therapeutics could future regenerative medicine strategies. Graphical

Language: Английский

Citations

0
Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration DOI
Pawan Kumar, Jitender Sharma, Ravinder Kumar

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.

Language: Английский

Citations

0
Influence of Mucoadhesive Polymers on Physicochemical Features and Biocompatibility of Collagen Wafers DOI Creative Commons
Ioana Luca, Mădălina Georgiana Albu Kaya, Irina Titorencu

et al.

ACS Polymers Au, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Binding of collagen I to integrins alleviates UVB-caused mitochondrial disorders in human keratinocytes HaCaT through enhancement of F-actin polymerization DOI
Yuying Zhu, Tiantian Ji,

Zhao San

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2025, Volume and Issue: 268, P. 113170 - 113170

Published: April 28, 2025

Language: Английский

Citations

0
Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges DOI Creative Commons

Ye Feng,

Hongpeng Li

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 5, 2024

Periodontal disease (PD) is a chronic inflammatory condition that affects the teeth and their supporting tissues, ultimately culminating in tooth loss. Currently, treatment modalities, such as systemic local administration of antibiotics, serve to mitigate progression inflammation yet fall short restoring original anatomical structure physiological function periodontal tissues. Biocompatible material-based tissue engineering seems be promising therapeutic strategy for treating PD. Collagen, component extracellular matrix commonly used engineering, has been regarded biogenic material regeneration owing its high cell-activating biocompatible properties. The structural chemical similarities between collagen components oral render it candidate dental regeneration. This review explored properties current applications We also discussed recent therapies preparation techniques. scrutinizes pros cons associated with application collagen-based biomaterials PD treatment, aiming pave way future management

Language: Английский

Citations

1
Embracing the future: The application of regenerative biomaterials in the spinal disorders DOI Creative Commons

Yiwen Xu,

Miaojie Fang,

Zilong Li

et al.

Biomedical Technology, Journal Year: 2024, Volume and Issue: 9, P. 100068 - 100068

Published: Dec. 25, 2024

Language: Английский

Citations

1
Collagen-based materials in male genitourinary diseases and tissue regeneration DOI Creative Commons
Fangyuan Li,

XinHuang,

Ruiying Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 1, 2024

Abstract Male genitourinary dysfunction causes serious physical or mental distress, such as infertility and psychological harm, which leads to impaired quality of life. Current conventional treatments involving drug therapy, surgical repair, tissue grafting have a limited effect on recovering the function fertility organs. To address these limitations, various biomaterials been explored, with collagen-based materials increasingly gaining attention for reconstructing male system due their superior biocompatibility, biodegradability, low antigenicity, biomimetic 3D matrix characteristics, hemostatic efficacy, regeneration capabilities. This review covers recent biomedical applications including treatment erectile dysfunction, premature ejaculation, penile girth enlargement, prostate cancer, Peyronie's disease, chronic kidney etc. Although there are relatively few clinical trials, promising results existing studies animal models reveal bright future in diseases. Graphic

Language: Английский

Citations

0