bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2021,
Номер
unknown
Опубликована: Март 1, 2021
Soft
bioelectronic
interfaces
for
mapping
and
modulating
excitable
networks
at
high
resolution
large
scale
can
enable
paradigm-shifting
diagnostics,
monitoring,
treatment
strategies.
Yet,
current
technologies
largely
rely
on
materials
fabrication
schemes
that
are
expensive,
do
not
scale,
critically
limit
the
maximum
attainable
coverage.
Solution
processing
is
a
cost-effective
manufacturing
alternative,
but
biocompatible
conductive
inks
matching
performance
of
conventional
metals
lacking.
Here,
we
introduce
MXtrodes,
novel
class
soft,
high-resolution,
large-scale
enabled
by
Ti
3
C
2
MXene
scalable
solution
processing.
We
show
electrochemical
properties
MXtrodes
exceed
those
materials,
require
gels
when
used
in
epidermal
electronics.
Furthermore,
validate
number
applications
ranging
from
neuromuscular
humans
to
delivering
cortical
microstimulation
small
animal
models.
Finally,
demonstrate
compatible
with
standard
clinical
neuroimaging
modalities.
Science Translational Medicine,
Год журнала:
2021,
Номер
13(612)
Опубликована: Сен. 22, 2021
Soft
bioelectronic
interfaces
for
mapping
and
modulating
excitable
networks
at
high
resolution
large
scale
can
enable
paradigm-shifting
diagnostics,
monitoring,
treatment
strategies.
Yet,
current
technologies
largely
rely
on
materials
fabrication
schemes
that
are
expensive,
do
not
scale,
critically
limit
the
maximum
attainable
coverage.
Solution
processing
is
a
cost-effective
manufacturing
alternative,
but
biocompatible
conductive
inks
matching
performance
of
conventional
metals
lacking.
Here,
we
introduce
MXtrodes,
class
soft,
high-resolution,
large-scale
enabled
by
Ti3C2
MXene
(a
two-dimensional
transition
metal
carbide
nanomaterial)
scalable
solution
processing.
We
show
electrochemical
properties
MXtrodes
exceed
those
require
gels
when
used
in
epidermal
electronics.
Furthermore,
validate
applications
ranging
from
neuromuscular
humans
to
cortical
neural
recording
microstimulation
swine
rodent
models.
Last,
demonstrate
compatible
with
standard
clinical
neuroimaging
modalities.
Chemical Reviews,
Год журнала:
2024,
Номер
124(5), С. 2205 - 2280
Опубликована: Фев. 21, 2024
Advances
in
soft
materials,
miniaturized
electronics,
sensors,
stimulators,
radios,
and
battery-free
power
supplies
are
resulting
a
new
generation
of
fully
implantable
organ
interfaces
that
leverage
volumetric
reduction
mechanics
by
eliminating
electrochemical
storage.
This
device
class
offers
the
ability
to
provide
high-fidelity
readouts
physiological
processes,
enables
stimulation,
allows
control
over
organs
realize
therapeutic
diagnostic
paradigms.
Driven
seamless
integration
with
connected
infrastructure,
these
devices
enable
personalized
digital
medicine.
Key
advances
carefully
designed
material,
electrophysical,
electrochemical,
electromagnetic
systems
form
implantables
mechanical
properties
closely
matched
target
deliver
functionality
supports
sensors
stimulators.
The
elimination
operation,
anywhere
from
acute,
lifetimes
matching
subject
physical
dimensions
imperceptible
operation.
review
provides
comprehensive
overview
basic
building
blocks
related
topics
such
as
implantation,
delivery,
sterilization,
user
acceptance.
State
art
examples
categorized
system
an
outlook
interconnection
advanced
strategies
for
computation
leveraging
consistent
influx
elevate
this
current
battery-powered
is
highlighted.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(34), С. 39159 - 39171
Опубликована: Авг. 16, 2022
Dry
epidermal
electrodes
that
can
always
form
conformal
contact
with
skin
be
used
for
continuous
long-term
biopotential
monitoring,
which
provide
vital
information
disease
diagnosis
and
rehabilitation.
But,
this
application
has
been
limited
by
the
poor
of
dry
on
wet
skin.
Herein,
we
report
a
biocompatible
fully
organic
electrode
both
even
during
physical
movement.
The
are
prepared
drop
casting
an
aqueous
solution
consisting
poly(3,4-ethylenedioxythiophene):polystyrenesulfonate
(PEDOT:PSS),
poly(vinyl
alcohol)
(PVA),
tannic
acid
(TA),
ethylene
glycol
(EG).
exhibit
conductivity
122
S
cm–1
mechanical
stretchability
54%.
Moreover,
they
self-adhesive
to
not
only
but
also
As
result,
lower
impedance
than
commercial
Ag/AgCl
gel
sweat
skins.
They
as
accurately
detect
signals
including
electrocardiogram
(ECG)
electromyogram
(EMG)
skins
users
at
rest
or
This
is
first
time
demonstrate
accurate
detection.
Physiological Measurement,
Год журнала:
2022,
Номер
43(2), С. 02TR01 - 02TR01
Опубликована: Янв. 28, 2022
Abstract
Electrodermal
activity
(EDA)
has
been
measured
in
the
laboratory
since
late
1800s.
Although
influence
of
sudomotor
nerve
and
sympathetic
nervous
system
on
EDA
is
well
established,
mechanisms
underlying
signal
generation
are
not
completely
understood.
Owing
to
simplicity
instrumentation
modern
electronics,
these
measurements
have
recently
seen
a
transfer
from
wearable
devices,
sparking
numerous
novel
applications
while
bringing
along
both
challenges
new
opportunities.
In
addition
developments
electronics
miniaturization,
current
trends
material
technology
manufacturing
sparked
innovations
electrode
technologies,
data
science
such
as
machine
learning
sensor
fusion
expanding
ways
that
measurement
can
be
processed
utilized.
remain
for
quality
measurement,
ongoing
research
may
shorten
gap
between
standardized
recordings
laboratory.
this
topical
review,
we
provide
an
overview
basics
discuss
opportunities
EDA,
review
recent
instrumentation,
technology,
processing,
modeling
tools
advance
field
over
coming
years.
Sensors,
Год журнала:
2021,
Номер
21(2), С. 340 - 340
Опубликована: Янв. 6, 2021
(1)
Background:
Low
back
disorders
are
a
leading
cause
of
missed
work
and
physical
disability
in
manual
material
handling
due
to
repetitive
lumbar
loading
overexertion.
Ergonomic
assessments
often
performed
understand
mitigate
the
risk
musculoskeletal
overexertion
injuries.
Wearable
sensor
solutions
for
monitoring
low
have
potential
improve
quality,
quantity,
efficiency
ergonomic
expand
opportunities
personalized,
continuous
injury
risk.
However,
existing
wearable
using
single
inertial
measurement
unit
(IMU)
limited
how
accurately
they
can
estimate
when
objects
varying
mass
handled,
alternative
scientific
literature
require
so
many
distributed
sensors
that
impractical
widespread
workplace
implementation.
We
therefore
explored
new
ways
monitor
small
number
sensors.
(2)
Methods:
synchronously
collected
data
from
laboratory
instrumentation
analyze
10
individuals
each
performing
about
400
different
tasks.
dozens
candidate
used
IMUs
on
various
body
locations
and/or
pressure
insoles.
(3)
Results:
found
two
key
trunk
IMU
Using
signals
these
together
with
Gradient
Boosted
Decision
Tree
algorithm
has
provide
practical
(relatively
few
sensors),
accurate
(up
r2
=
0.89),
automated
way
(using
wearables)
time
series
moments
across
broad
range
The
could
be
replaced
by
thigh
IMUs,
or
pelvis
IMU,
without
sacrificing
much
accuracy,
but
there
was
no
substitute
realizing
load
estimates
this
approach
real
world
will
optimizing
force
(4)
Conclusions:
Here,
we
present
promising
solution
practical,
automated,
during
handling.
Sensors,
Год журнала:
2024,
Номер
24(6), С. 1810 - 1810
Опубликована: Март 11, 2024
The
adoption
of
high-density
electrode
systems
for
human–machine
interfaces
in
real-life
applications
has
been
impeded
by
practical
and
technical
challenges,
including
noise
interference,
motion
artefacts
the
lack
compact
interfaces.
To
overcome
some
these
we
introduce
a
wearable
stretchable
electromyography
(EMG)
array,
present
its
design,
fabrication
methodology,
characterisation,
comprehensive
evaluation.
Our
proposed
solution
comprises
dry-electrodes
on
flexible
printed
circuit
board
(PCB)
substrates,
eliminating
need
time-consuming
skin
preparation.
method
allows
manufacturing
sleeves,
with
consistent
standardised
coverage
across
subjects.
We
thoroughly
tested
our
developed
prototype,
evaluating
potential
application
both
research
real-world
environments.
results
study
showed
that
array
matches
or
outperforms
traditional
EMG
grids
holds
promise
furthering
translation
Abstract
Graphene
is
a
single
layered
two‐dimensional
structure
of
graphite
and
it
has
been
flaming
topic
research
due
to
its
remarkable
properties.
The
efficiency
graphene‐based
materials
exploited
in
many
spheres
life
ranging
from
biosensing,
targeted
drug
delivery,
bio‐imaging,
quantum
physics,
transportation,
energy
storage
devices,
faster
electronics,
more.
made
monolayer
sp
2
carbon
atoms
organized
hexagonal
pattern
with
C−C
bond
length
1.42
A.
attracted
interest
the
development
electrochemical
sensors
biosensors
excellent
electrical
conductivity,
significant
surface
area,
high
electron
transfer
potential.
Because
these
exclusive
characteristics,
also
become
suitable
contender
for
extensive
biomedical
uses
that
favors
differentiation
human
mesenchymal
stem
cells
(MSC)
into
bone
inhibit
proliferation
cells,
fluorescence
quenching,
drug/gene
tissue
engineering
antitumor
treatments.
In
last
ten
years,
notable
conducted
explore
applications.
Encouraged
by
numerous
successful
integrations
fields,
up‐to‐date
developments
graphene
applications
various
dimensions
field
such
as
biosensors,
gene
photo‐thermal
therapy,
bio‐imaging
are
summarized
here.
Sensors,
Год журнала:
2020,
Номер
20(24), С. 7348 - 7348
Опубликована: Дек. 21, 2020
Wearable
devices
play
an
increasing
role
in
the
rehabilitation
of
patients
with
movement
disorders.
Although
information
about
muscular
activation
is
highly
interesting,
no
approach
exists
that
allows
reliable
collection
this
when
sensor
applied
autonomously
by
patient.
This
paper
aims
to
demonstrate
proof-of-principle
innovative
sEMG
system,
which
can
be
used
intuitively
while
detecting
their
sufficient
accuracy.
The
system
utilizes
a
multichannel
based
on
16
leads
arranged
circularly
around
limb.
Its
design
enables
stable
contact
between
skin
surface
and
system’s
dry
electrodes,
fulfills
SENIAM
recommendations
regarding
electrode
size
inter-electrode
distance
facilitates
high
temporal
resolution.
was
demonstrated
elbow
flexion/extension
movements
10
subjects,
proving
it
has
root
mean
square
values
signal-to-noise
ratio
comparable
commercial
systems
pre-gelled
electrodes.
Furthermore,
easily
placed
removed
reduced
arm
function
without
detailed
knowledge
exact
positioning
With
its
features,
demonstration
positions
as
wearable
device
potential
monitor
home
community
settings.
