Anti-Inflammatory and Antioxidant Effects of White Grape Pomace Polyphenols on Isoproterenol-Induced Myocardial Infarction

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2035 - 2035

Опубликована: Фев. 26, 2025

Grape pomace (GP), the residue left after grape pressing in winemaking, is rich polyphenols, including flavonoids, tannins, and phenolic acids, which have antioxidant anti-inflammatory properties. The present study aimed to evaluate cardioprotective effects of white (WGP) extract two concentrations polyphenols (795 mg from WGP/kg body weight (bw) 397.5 bw)), on isoproterenol (ISO)-induced myocardial infarction (MI), focusing its effects. White administration for 14 days offered a cardio-protective effect prevented prolongation QT QTc intervals electrocardiogram. Both WGP elevation nitric oxide (NO) malondialdehyde (MDA) serum, with best results being observed highest concentration (p < 0.05). reduction pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), 1β (IL-1β) both serum tissue dose-dependent manner, having Moreover, reduced histological changes associated MI. findings demonstrate that exerts cardio protective by reducing MI-associated inflammation oxidative stress.

Язык: Английский

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Discrimination of Romanian Wines Based on Phenolic Composition and Identification of Potential Phenolic Biomarkers for Wine Authenticity and Traceability

Beverages, Год журнала: 2025, Номер 11(2), С. 44 - 44

Опубликована: Март 25, 2025

Demonstrating the authenticity and traceability of quality wines based on parameters that reflect their composition provenance contributes to protecting wine increasing consumer confidence in moderate consumption, which is associated with numerous health-promoting properties. A wine’s phenolic fingerprint increasingly used assess its authenticity, even though influenced by genetic environmental factors, as well vineyard management enological practices, storage conditions. This study presents a comprehensive analysis bioactive characteristics (total polyphenols—TPs, total flavonoids—TFs, antioxidant activity—AA, anthocyanins—TAs) spectrophotometric compound profile (by UHPLC-HRMS analysis) 19 white 21 red Protected Designation Origin (PDO) from four vineyards located wine-growing region Oltenia, Romania. Multivariate statistical analysis, specifically principal component heat map applied analytical data, enables discrimination grape variety terroir, across consecutive vintages (2019–2022). The profiles obtained under standardized winemaking conditions depend climatic data specific each harvest year (temperature, precipitation, duration sun exposure during berry phenological stages, ripening). biomarkers wines, such epicatechin, catechin, gallic, caffeic, t-ferulic acids, t-resveratrol hesperidin, represent warmer sunnier years lower observed 2021 year. Additionally, our results contribute identification for geographical varietal discrimination, promotion high-quality produced renowned

Язык: Английский

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Total and bioaccessible contents of phenolic bioactives in nutritious flours exposed to consumption in Salvador, Bahia, Brazil using in vitro gastrointestinal digestion (INFOGEST protocol)

Food Chemistry, Год журнала: 2025, Номер 482, С. 144151 - 144151

Опубликована: Апрель 2, 2025

Язык: Английский

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Antioxidant and neuroprotective effects of nutriosomes and grape pomace phytochemicals in a cell model of oxidative stress and mouse model of Parkinson disease

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 8, 2025

The aim of the present study was to evaluate effectiveness a Cannonau pomace extract loaded in nutriosomes intestinal oxidative stress and subacute model Parkinson disease compare results with those previously obtained Nasco same nutriosomes. In this study, extracted using ultrasound-assisted maceration obtain polyphenol-rich extract. at two different concentrations (5 10 mg/mL) used deliver were main physico-chemical technological characteristics vesicles, along their stability over time measured. vitro biocompatibility ability protect epithelial cells (Caco-2) from damages, evaluated. Finally, repeated administration dispersion or against neurotoxic effects mice resulting vesicles had uniform distribution, controlled release payloads, biocompatible, like loading extract, protected damages induced by hydrogen peroxide, better extent than However, no significant neuroprotective observed vivo experiments performed disease, unlike previous This discrepancy is possibly due absence key polyphenols procyanidin B2 which are instead findings suggest that while enhance bioavailability efficacy grape extracts vitro, therapeutic potential may depend on specific phenolic profile used. Further research needed optimize formulations explore synergistic combinations for improved outcomes.

Язык: Английский

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Developments, Applications, and Innovations in Agricultural Sciences and Biotechnologies

Applied Sciences, Год журнала: 2025, Номер 15(8), С. 4381 - 4381

Опубликована: Апрель 16, 2025

The global population is projected to reach approximately 10 billion by 2050, and the demand for food expected increase 60–70% [...]

Язык: Английский

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Valorization of grape pomace by microbial fermentation: composition, biological activities and potential applications for the food industry

Journal of Food Composition and Analysis, Год журнала: 2025, Номер unknown, С. 107656 - 107656

Опубликована: Апрель 1, 2025

Язык: Английский

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Valorization of Dehydrated Grape Pomace Waste as a Low-Cost Feed Additive to Improve Reproduction and Growth Performance of Male Rabbits

Waste and Biomass Valorization, Год журнала: 2024, Номер 15(7), С. 3987 - 3996

Опубликована: Фев. 6, 2024

Язык: Английский

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Gut Microbiota Modulators Based on Polyphenols Extracted from Winery By-Products and Their Applications in the Nutraceutical Industry

Life, Год журнала: 2024, Номер 14(3), С. 414 - 414

Опубликована: Март 20, 2024

Vine-growing for the production of wine is one oldest and most important agricultural activities worldwide, but winemaking process leads to vast amounts waste. Viticulture vinification by-products have many bioactive molecules, including polyphenols, prebiotic fibers, organic acids, minerals. While research on specific human health effects grapevine residues (pomace, seeds, barks, stalks, canes, leaves) still ongoing, available data suggest potential positively modulate normal dysbiotic gut microbiota (GM) using polyphenol-rich extracts obtained from winery by-products. This review provides an updated summary in vitro vivo evidence animal models humans concerning ability residue be used as a GM modulator that supports their nutraceutical applications functional ingredient. Additionally, this aims enhance interest viticulture waste (grapevine stems leaves), levels polyphenols are similar those found red grapes or seeds. However, more needed obtain innovative products. The valorization not only environmentally friendly; it can also economically beneficial, creating added-value nutraceuticals new revenue stream producers.

Язык: Английский

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Transforming Wine By-Products into Energy: Evaluating Grape Pomace and Distillation Stillage for Biomass Pellet Production

Applied Sciences, Год журнала: 2024, Номер 14(16), С. 7313 - 7313

Опубликована: Авг. 20, 2024

The by-products of the wine industry represent a global production 10.5 to 13.1 million tons pomace annually. This study examines chemical composition and energy potential distillation stillage, evaluating their suitability for pellet within ENplus® standards. Proximate analysis, elemental calorimetric analysis were conducted on samples two collected in local Distillery Portugal. results reveal that has higher volatile matter content (62.695%) than which, however, lower ash (3.762%) fixed carbon (31.813%). Calorimetric analyses show stillage superior low heating value compared pomace, with values exceeding 19 MJ/kg. Both by-products, exceed limits (≤0.70), nitrogen (≤0.3), sulfur (≤0.04) content, presenting challenges use as high-quality fuel pellets. Combining these biomasses other materials could reduce pollutant improve efficiency. highlights need pre-treatment strategies enhance combustion. Policy support sustainable practices is essential optimize renewable sources.

Язык: Английский

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Winemaking: “With One Stone, Two Birds”? A Holistic Review of the Bio-Functional Compounds, Applications and Health Benefits of Wine and Wineries’ By-Products

Fermentation, Год журнала: 2023, Номер 9(9), С. 838 - 838

Опубликована: Сен. 13, 2023

The plethora of bio-functional compounds present in fermented alcoholic beverages like wine, as well the valorisation bioactives from wineries’/breweries’ by-products grape pomace and seed, has gained significant interest functional foods sector. This beverage, always accompanied humanity, for religion or health, especially Mediterranean, while benefits its moderate consumption were documented even by Greek physician Hippocrates Kos (460–370 BC). After a big gap, an outbreak research on wine surfaced only since 1990s, when term “French paradox” was introduced to US public during CBS show, recent evidence outlined that beneficial effects are derived synergisms their digestion-derived metabolites. Within this article, proposed health consumption, component balanced diet (i.e., Mediterranean diet) against inflammation-related chronic disorders, is thoroughly reviewed. various both wineries’ by-products, such bioactive phenolics, unsaturated fatty acids, polar lipids dietary fibres, antioxidant, anti-inflammatory antithrombotic health-promoting properties, also evaluated. mechanisms action synergism, which elicited, explored. Functional properties non-alcoholic products introduced. Emphasis given applications bioactives, ingredients foods, supplements nutraceuticals. Limitations future perspectives popular beverage (wine) rich addressed.

Язык: Английский

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