Natural Product Research,
Год журнала:
2022,
Номер
37(11), С. 1917 - 1934
Опубликована: Сен. 12, 2022
Chronic
urticaria
(CU)
is
a
pathologic
condition
marked
by
the
emergence
of
wheals,
angioedema,
or
both
for
more
than
six
weeks.
The
improper
activation
and
degranulation
mast
cells
triggering
event,
which
results
in
production
various
mediators
such
as
histamine,
leukotrienes,
PAF,
chemokines,
cytokines.
Antihistamines
are
currently
most
common
pharmacological
treatment
urticaria,
but
corticosteroids
monoclonal
antibodies
can
also
be
employed.
Patients
who
have
been
taking
antihistamines
long
time
often
looking
alternatives.
Whole
plants,
portions
single
extracted
active
compounds
all
used
phytomedicine.
Plant
elements
frequently
combined
to
create
formulations
that
utilized
treat
variety
pathological
disorders.
Anti-inflammatory
and/or
anti-allergic
properties
found
several
herbs
regularly
herbal
formulations.
Antioxidant
present
some
constituents.
Exogenous
antioxidants
shown
improve
progression
autoimmune
disorders
numerous
studies.
aim
this
review
identify
chronic
characterize
their
efficacy,
mechanisms
action,
risk/benefit
ratio
comparison
western
treatment,
find
less
assess
therapeutic
safety
profile,
potential
wider
use.
Journal of Xenobiotics,
Год журнала:
2024,
Номер
14(3), С. 923 - 938
Опубликована: Июль 10, 2024
This
study
examines
the
physiological
and
immunological
effects
of
0.5
ppm
carbaryl
exposure
on
juvenile
Asian
seabass
(Lates
calcarifer)
over
12
h
to
72
h.
Notable
results
include
decreased
activities
liver
enzymes
catalase
(CAT),
lactate
dehydrogenase
(LDH),
glutathione
peroxidase
(GSH-PX),
while
superoxide
dismutase
(SOD)
levels
remained
stable,
with
lowest
CAT
GSH-PX
observed
at
Serum
biochemistry
revealed
increased
alkaline
phosphatase
(AKP)
acid
(ACP)
24
h,
declining
aspartate
aminotransferase
(AST)
a
peak
in
creatinine
48
Histopathological
analysis
showed
carbaryl-induced
necrosis
spleen
cells,
melanomacrophage
centers
both
organs.
Additionally,
immune
gene
expression
indicated
an
upregulation
heat
shock
proteins
consistent
elevation
complement
component
C3
interleukin-8
(IL-8).
These
findings
suggest
that
significantly
impairs
organ
function
modulates
responses
L.
calcarifer,
underlining
need
for
further
research
protective
strategies
against
pesticide
impacts
aquaculture.
Natural Product Research,
Год журнала:
2022,
Номер
37(5), С. 798 - 802
Опубликована: Июнь 16, 2022
This
study
aimed
to
investigate
the
protective
effects
and
mechanisms
of
myricetin
on
acute
liver
failure
in
mice
induced
by
lipopolysaccharide
(LPS)/D-galactosamine
(D-Gal).
Our
results
showed
(25,
50
100
mg/kg)
pretreatment
significantly
improved
pathological
changes
tissues,
decreased
serum
ALT
AST
(p
<
0.001)
LPS/D-GalN.
Moreover,
MDA
MPO
levels
were
reduced
0.001),
CAT
SOD
activities
increased
with
(50
pretreatment.
Likewise,
inflammatory
cytokines
TNF-α
IL-6
mRNA
tissues
markedly
myricetin.
Besides,
Nrf2
protein
expression
was
drastically
elevated
mg/kg).
All
these
findings
imply
that
may
protect
against
suppressing
inflammation
regulating
oxidative
stress
via
signaling,
it
be
a
possible
strategy
avoid
damage.
Acta Histochemica,
Год журнала:
2023,
Номер
125(3), С. 152031 - 152031
Опубликована: Апрель 1, 2023
The
integument
acts
as
a
barrier
to
protect
the
body
from
harmful
pathogenic
infectious
agents,
parasites,
UV
rays,
trauma,
and
germs.
of
invertebrates
vertebrates
are
structurally
different:
while
usually
have
simple
monolayer
epidermis
frequently
covered
by
mucus,
cuticles,
or
mineralized
structures,
possess
multilayered
with
several
specialized
cells.
This
study
aims
describe
morphological,
histological,
immunohistochemical
analyses,
morpho-structural
adaptations
throughout
evolution
gastropod
Aplysia
depilans
(Gmelin,
1791),
ascidian
Styela
plicata
(Lesuer,
1823),
myxine
hagfish
Eptatretus
cirrhatus
(Forster,
1801)
teleost
Heteropneustes
fossilis
(Bloch,
1794)
for
first
time,
special
reference
sensory
epidermal
Different
types
cells
could
be
identified
that
varied
according
species;
including
mucous
cells,
serous
glandular
clavate
club
thread
support
In
all
integuments
specimens
analyzed,
solitary
were
in
epidermis,
immunoreactive
serotonin
calbindin.
Our
provided
an
essential
comparison
integuments,
adding
new
information
about
phylogenetic
conservation
on
structural
changes
undergone
during
evolution.
Natural Product Research,
Год журнала:
2022,
Номер
37(11), С. 1917 - 1934
Опубликована: Сен. 12, 2022
Chronic
urticaria
(CU)
is
a
pathologic
condition
marked
by
the
emergence
of
wheals,
angioedema,
or
both
for
more
than
six
weeks.
The
improper
activation
and
degranulation
mast
cells
triggering
event,
which
results
in
production
various
mediators
such
as
histamine,
leukotrienes,
PAF,
chemokines,
cytokines.
Antihistamines
are
currently
most
common
pharmacological
treatment
urticaria,
but
corticosteroids
monoclonal
antibodies
can
also
be
employed.
Patients
who
have
been
taking
antihistamines
long
time
often
looking
alternatives.
Whole
plants,
portions
single
extracted
active
compounds
all
used
phytomedicine.
Plant
elements
frequently
combined
to
create
formulations
that
utilized
treat
variety
pathological
disorders.
Anti-inflammatory
and/or
anti-allergic
properties
found
several
herbs
regularly
herbal
formulations.
Antioxidant
present
some
constituents.
Exogenous
antioxidants
shown
improve
progression
autoimmune
disorders
numerous
studies.
aim
this
review
identify
chronic
characterize
their
efficacy,
mechanisms
action,
risk/benefit
ratio
comparison
western
treatment,
find
less
assess
therapeutic
safety
profile,
potential
wider
use.
