International Journal of Morphology,
Год журнала:
2024,
Номер
42(3), С. 819 - 825
Опубликована: Июнь 1, 2024
Cadmium
(Cd)
is
a
toxic
element
that
accumulates
in
kidney
and
liver.L-carnitine(LC)
natural
compound
has
been
shown
to
exhibit
antioxidant
activity.Aim
of
this
study
was
investigate
the
effect
L-carnitine
against
cadmium-induced
changes
liver
tissues
prepubertal
female
rats.In
21-day-old
Wistar
Albino
rats
were
used.Control,
cadmium
(2
mg/kg
intraperitoneally),
(300
orally)
cadmium+L-carnitine
groups
formed.Liver
tissue
sections
stained
with
Hematoxylin-Eosin
Masson
Trichrome.Histological
scoring
performed
kidney.In
given
Cd,
bile
duct
proliferation,
inflammation
cells
connective
portal
area
decreased
treatment
group.In
kidneys,
group
treated
L-carnitine,
it
observed
capillary
congestion
kidneys
decreased,but
tubular
dilatation
continued
some
places.In
fibrosis
groups,statistically
significant
decrease
Cd+LC
compared
cadmium.In
histological
results
groups,
statistically
epithelial
degeneration
conclusion
medium-dose
effects
subacute
period,these
are
alleviated
L-carnitine.
Atmosphere,
Год журнала:
2025,
Номер
16(2), С. 225 - 225
Опубликована: Фев. 17, 2025
Cadmium
(Cd)
is
a
pervasive
environmental
and
industrial
toxin
that
poses
significant
health
risks.
It
readily
moves
through
soil–plant
systems,
leading
to
global
contamination
human
exposure
diet,
smoking,
pollution.
The
main
purpose
of
this
review
explore
the
effect
Cd
on
physiological
processes
different
bodies’
organs,
including
bones,
kidneys,
liver,
as
well
immune,
cerebrovascular,
cardiovascular,
reproductive
systems.
Accumulation
in
body
can
result
poisoning
with
severe
impacts
bone
kidney
health,
reduced
mineral
density
due
renal
damage.
Research
has
linked
lung
cancer
pulmonary
toxicity,
elevated
urinary
biomarkers
suggest
compromised
function.
also
affects
immune
systems;
liver;
contributing
various
diseases
by
disrupting
blood
pressure
calcium
regulation,
causing
oxidative
stress
DNA
damage,
impairing
cell
functions.
Ongoing
research
essential
fully
understand
Cd-induced
toxicological
effects
develop
effective
interventions
prevent
mitigate
Environmental Pollution,
Год журнала:
2023,
Номер
337, С. 122606 - 122606
Опубликована: Сен. 22, 2023
Cadmium
(Cd)
is
known
as
a
widespread
environmental
neurotoxic
pollutant.
Cd
exposure
recently
recognized
an
etiological
factor
of
Parkinson's
disease
(PD)
in
humans.
However,
the
mechanism
underlying
neurotoxicity
relation
to
Parkinsonism
pathogenesis
unclear.
In
our
present
study,
C57BL/6
J
mice
were
exposed
100
mg/L
CdCl2
drinking
water
for
8
weeks.
It
was
found
caused
motor
deficits,
decreased
DA
neurons
and
induced
neuropathological
changes
midbrain.
Non-targeted
lipidomic
analysis
uncovered
that
altered
lipid
profile,
increased
content
proinflammatory
sphingolipid
ceramides
(Cer),
sphingomyelin
(SM)
ganglioside
(GM3)
consistency
with
lipids,
mRNA
levels
genes
encoding
sphingolipids
biosynthesis
midbrain
dysregulated
by
exposure.
Neuroinflammation
evinced
up-regulation
cytokines
at
protein
levels.
Blood
contents
metabolites
patients
ICP-MS
LC-MS/MS
analyses
demonstrated
elevated
blood
concentration
positively
associated
score
Unified
Disease
Rating
Scale
(UPDRS).
3
ceramide
showed
good
specificity
candidate
biomarkers
predict
monitor
(AUC>0.7,
p
<
0.01).
summary,
study
perturbed
metabolism
related
neurotoxicity,
partially
compensated
deficiency
particular
metabolic
exposure,
emphasized
necessity
reducing
population
level.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Сен. 12, 2024
As
a
non-essential
metal,
cadmium
(Cd)
poses
significant
threat
to
food
safety
and
public
health.
This
risk
is
particularly
pronounced
for
infants
young
children
due
their
high
consumption
relative
body
weight
immature
physiological
systems.
review
examines
the
health
risks
associated
with
Cd
exposure,
during
prenatal
period
through
adolescence.
It
evaluates
prevalence
of
Cd-rich
foods
in
children's
diets
intake
levels
across
various
countries.
The
demonstrates
that
exposure
neurodevelopmental
disorders,
immune
dysfunction,
cardiovascular
diseases.
also
highlights
geographic
differences
some
Asian
countries,
such
as
Thailand
China,
exhibiting
higher
overall
among
compared
other
regions.
presents
several
recommendations
mitigate
early
childhood,
including
reducing
content
food,
inhibiting
absorption,
promoting
its
excretion
from
body.
To
minimize
dietary
children,
it
recommended
stringent
regulations
limits
be
implemented,
alongside
coordinated
multi-stakeholder
effort.
provides
important
insights
into
effective
policy
development,
laying
foundation
achieving
broader
goals.
