Potential toxicity of microplastics on vertebrate liver: A systematic review and meta–analysis DOI Creative Commons

Huiling Zhang,

Yameng Gao,

Yan Zheng

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117166 - 117166

Опубликована: Окт. 12, 2024

Язык: Английский

Microplastics in Freshwater Systems: A Review of Classification, Sources, and Environmental Impacts DOI Creative Commons

Kalampyr Bexeitova,

Alzhan Baimenov, Esin Apaydın Varol

и другие.

Chemical Engineering Journal Advances, Год журнала: 2024, Номер unknown, С. 100649 - 100649

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

14
Enzymatic degradation of polybutylene succinate by recombinant cutinase cloned from Paraphoma chrysanthemicola DOI
Jingwei Lin, K. Sun,

Li Ma

и другие.

Journal of Environmental Management, Год журнала: 2025, Номер 375, С. 124288 - 124288

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

2
Experimental study on enhanced magnetic removal of microplastics in water using modified maifanite DOI
Changliang Shi,

Jingjun Geng,

Xiaojing Qu

и другие.

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116014 - 116014

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Microplastics and nanoplastics: Exposure and toxicological effects require important analysis considerations DOI Creative Commons
Emmanouil Tsochatzis, Helen Gika, Georgios Theodoridis

и другие.

Heliyon, Год журнала: 2024, Номер 10(11), С. e32261 - e32261

Опубликована: Май 31, 2024

Microplastics (MPs) and nanoplastics (NPs) pervade both the environment food chain, originating from degradation of plastic materials various sources. Their ubiquitous presence raises concerns for ecosystem safety, as well health animals humans. While evidence suggests their infiltration into mammalian human tissues association with several diseases, precise toxicological effects remain elusive require further investigation. MPs NPs sample preparation analytical methods are quite scattered without harmonised strategies to exist at moment.A significant challenge lies in limited availability chemical characterization quantification these contaminants. can undergo degradation, driven by abiotic or biotic factors, resulting formation cyclic linear oligomers. These oligomers serve indicative markers exposure NPs. Moreover, recent finding concerning aggregation form NPs, makes analysis very important.Recent advancements have led development sensitive robust identifying (semi)quantifying environmental, food, biological samples. offer a valuable complementary approach determining assessing risk environment.

Язык: Английский

Процитировано

9
Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice DOI Creative Commons

Yiqian Wen,

Shiyi Deng,

Binhui Wang

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 278, С. 116439 - 116439

Опубликована: Май 9, 2024

Nanoplastic contamination has been of intense concern by virtue the potential threat to human and ecosystem health. Animal experiments have indicated that exposure nanoplastics (NPs) can deposit in liver contribute hepatic injury. To explore mechanisms hepatotoxicity induced polystyrene-NPs (PS-NPs), mice AML-12 hepatocytes were exposed different dosages 20 nm PS-NPs this study. The results illustrated vitro vivo triggered excessive production reactive oxygen species repressed nuclear factor erythroid-derived 2-like 2 (NRF2) antioxidant pathway its downstream antioxidase expression, thus leading oxidative stress. Moreover, elevated levels NLRP3, IL-1β caspase-1 along with an activation NF-κB, suggesting hepatocellular inflammatory Nevertheless, activaton NRF2 signaling tert-butylhydroquinone mitigated PS-NPs-caused stress inflammation, inbihited NLRP3 expression. Conversely, rescuing effect signal was dramatically supressed treatment inhibitor brusatol. In summary, our demonstrated NRF2-NLRP3 is involved PS-NPs-aroused hepatotoxicity, protect against PS-NPs-evoked These provide novel insights into elicited NPs exposure.

Язык: Английский

Процитировано

7
CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium DOI Creative Commons
Zhixuan Chen,

Huayi Qu,

Jian Sun

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Cadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function potential mechanisms. In this study, C57BL/6 mice AML12 cells were used to establish in vivo vitro models elucidate the of combined exposure PS-MPs Cd their The results showed that caused significantly more damage than alone. As observed by transmission electron microscopy (TEM), number autophagosomes was increased co-treated group. addition, autophagic flux assayed RFP-GFP-LC3, a reporter system expressing dual fluorescent proteins, which an overwhelming enhancement co-exposure compared To further investigate involvement carnitine palmitoyltransferase1(CPT1) injury induced PS-MPs, we co-exposed Baicalin, activator CPT1, with Cd, activation CPT1 alleviated impairment fluxes changes lipid accumulation associated protein levels. conclusion, concurrent resulted blockage hepatic pathway aggravated toxic liver. Activation could alleviate Cd-induced autophagy thus reducing injury.

Язык: Английский

Процитировано

1
Polystyrene Microplastics Trigger Colonic Inflammation in Rats via the TLR4/NF-κB/COX-2 Pathway and Modulation of Intestinal Microbiota DOI

Xuemin Feng,

Meng Zhang, Tianyang Zhao

и другие.

Toxicology, Год журнала: 2025, Номер 513, С. 154090 - 154090

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

1
Are bioplastics the solution to the plastic pollution problem? DOI Creative Commons
Sandra Pascoe Ortíz

PLoS Biology, Год журнала: 2023, Номер 21(3), С. e3002045 - e3002045

Опубликована: Март 22, 2023

We live our lives immersed in plastic pollution: a problem that is becoming more acute. Viable alternatives can reduce pollution are being sought. Could bioplastics be the hoped-for solution to this problem?

Язык: Английский

Процитировано

15
The size-dependent effects of nanoplastics in mouse primary hepatocytes from cells to molecules DOI

Yaoyue Wang,

Xingchen Zhao,

Houquan Tang

и другие.

Environmental Pollution, Год журнала: 2024, Номер 355, С. 124239 - 124239

Опубликована: Май 27, 2024

Язык: Английский

Процитировано

6
Nanoplastic propels diet-induced NAFL to NASH via ER-mitochondrial tether-controlled redox switch DOI Creative Commons
Jie Wei, Jintao Liu, Huan Wang

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 465, С. 133142 - 133142

Опубликована: Дек. 1, 2023

Nonalcoholic steatohepatitis (NASH) is multifactorial that lifestyle, genetic, and environmental factors contribute to its onset progression, thereby posing a challenge for therapeutic intervention. Nanoplastic (NP) emerged as novel metabolism disruptor but the etiopathogenesis remains largely unknown. In this study, C57BL/6 J mice were fed with normal chow diet (NCD) high-fat (HFD) containing 70 nm polystyrene microspheres (NP). We found dietary-derived NP adsorbed proteins agglomerated during in vivo transportation, enabling diet-induced hepatic steatosis NASH. Mechanistically, promoted liver by upregulating Fatp2. Furthermore, stabilized Ip3r1, facilitated ER-mitochondria contacts (MAMs) assembly hepatocytes, resulting mitochondrial Ca

Язык: Английский

Процитировано

12