Vitamin C and/or garlic can antagonize the toxic effects of cadmium on growth performance, hematological, and immunological parameters of growing Japanese quail

Poultry Science, Год журнала: 2024, Номер 103(3), С. 103457 - 103457

Опубликована: Янв. 11, 2024

This study used 300 one-day-old, sexless, developing chicks of Japanese quail to estimate the ability vitamin C and/or garlic antagonize venomous influence cadmium (Cd) on hematological, immunological, and performance characteristics quail. The was separated into five similar groups 60 apiece, six duplicates (10 each) were given each sub-group. control group received a basal diet without any supplements. Cd nourished with + 80 mg chloride (CdCl2)/kg diet. 3rd fed CdCl2 /kg complemented 200 Vitamin (Cd+ C)/kg 4th by 500 dried powder G)/kg 5th diet, CG)/kg Results showed that in which added together Vit garlic, there an improvement both live weight gain (1-42 days) feed consumption (1-21 & 1-42 compared alone. addition alone seems completely improve cadmium-related increase alkaline phosphatase (ALP), Aspartate aminotransferase (AST) Malondialdehyde (MDA) levels when control. Compared cadmium-polluted diets, got additives significantly reduced residue. In addition, group's serum immunoglobulin M (IgM) level decreased significantly. These data imply dietary supplementation (C) or (G) may be beneficial retrogressing drop G (IgG) IgM caused minimizing Cd's deleterious immunity.

Язык: Английский

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An overview of the ameliorative efficacy of Catharanthus roseus extract against Cd2+ toxicity: implications for human health and remediation strategies

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Март 8, 2024

Rapid industrialization has led to an increase in cadmium pollution, a dangerously toxic heavy metal. Cadmium (Cd) is released into the environment through industrial processes and can contaminate air, water, soil. This pollution poses significant risk human health become pressing concern many industrialized areas. Due its extended half-life, it leads range of problems, including hepato-nephritic toxicity, brain damage, degenerative bone disorders. Intoxication alters various intracellular parameters, leading inflammation, tissue injury, oxidative stress within cells, which disrupts normal cellular functions eventually result cell death. It also been linked development diseases such as osteoporosis. These adverse effects highlight urgent need address find effective solutions mitigate impact on health. article highlights Cd-induced risks role Catharanthus roseus ( C. ) extract source alternative medicine alleviating symptoms. Numerous herbal remedies often contain certain bioactive substances, polyphenols alkaloids, have power these by acting antioxidants lowering damage. Research conducted field revealed enormous potential meet demands that may be effectively used safeguarding humans their environment. The point this review investigate whether extract, known for being investigated harmful Further investigation needed fully understand effectiveness. Moreover, important explore environmental benefits using reduce negative Cd. could implications both sustainability.

Язык: Английский

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Histopathological effects of long-term exposure to realistic concentrations of cadmium in the hepatopancreas of Sparus aurata juveniles

Aquatic Toxicology, Год журнала: 2024, Номер 268, С. 106858 - 106858

Опубликована: Фев. 5, 2024

Язык: Английский

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Study on the effect of Shewanella oneidensis MR-1 coupled with the low molecular weight organic acid on the dissimilation reduction of Cd-containing goethite

Journal of Environmental Management, Год журнала: 2025, Номер 379, С. 124843 - 124843

Опубликована: Март 9, 2025

Язык: Английский

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The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: evidence from two cohort studies

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 24, 2025

The American Heart Association (AHA) proposed the concept of cardiovascular–kidney–metabolic (CKM) syndrome, underscoring interconnectedness cardiovascular, renal, and metabolic diseases. stress hyperglycemia ratio (SHR) represents an innovative indicator that quantifies blood glucose fluctuations in patients experiencing acute or subacute stress, correlating with detrimental clinical effects. Nevertheless, prognostic significance SHR within individuals diagnosed CKM syndrome stages 0 to 3, particularly respect all-cause cardiovascular disease (CVD) mortality risks, has not been fully understood yet. current study analyzed data from 9647 participants covering based on NHANES (National Health Nutrition Examination Survey) collected 2007 2018. In this study, primary exposure variable was SHR, computed as fasting plasma divided by (1.59 * HbA1c − 2.59). main endpoints were well CVD mortality, death registration sourced through December 31, 2019. CHARLS database (China Retirement Longitudinal Study) utilized validation enhance reliability findings. This included participants, who followed for a median duration 6.80 years. During period, 630 cases 135 CVD-related deaths total recorded. After full adjustment covariates, our results displayed robust positive association (Hazard [HR] = 1.09, 95% Confidence interval [CI] 1.04–1.13). However, exhibited no significant relationship (HR 1.00, CI 0.91–1.11). mediation analysis suggested between risk is partially mediated RDW, albumin, RAR. Specifically, mediating effects 17.0% (95% 46.7%, 8.7%), 10.1% 23.9%, 4.7%), 23.3% 49.0%, 13.0%), respectively. Additionally, analyses indicated correlation among across 0–3 during follow-up period 2011 2020. An increased value positively associated elevated likelihood 0–3, yet it shows mortality. important tool predicting long-term adverse outcomes population. Cardiovascular–kidney–metabolic emphasizes kidney, novel marker reflecting stress-induced fluctuations, but its (stages 0–3) remains uncertain. explores Our findings indicate significantly 1.04–1.13), CI: Mediation Validation using supports these These suggest could serve biomarker patients, offering potential utility stratification management.

Язык: Английский

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Exercise antagonizes cadmium-caused liver and intestinal injury in mice via Nrf2 and TLR2/NF-κB signalling pathway

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 294, С. 118100 - 118100

Опубликована: Апрель 1, 2025

Cadmium (Cd) causes a health risk to humans and animals. Exercise can prevent treat variety of diseases, but the effect mechanism exercise on cadmium poisoning are still unclear. The present research aims investigate antagonistic impacts enterotoxicity hepatotoxicity caused by Cd. results indicated that exercise, both before during Cd exposure, reduce pathological damages in liver duodenum mice, suppressing expression levels IL-1β, IL-6 TNF-α genes. In mice exposed Cd, significantly decreased blood ALT AST levels, alleviating oxidative stress reducing MDA synthesis enhancing SOD GSH-PX activities. inhibited nuclear damage hepatocyte apoptosis increasing Bcl-2 protein preventing release pro-apoptotic proteins such as caspase-3, Cytc, Bax, caspase-8and cleaved-caspase-3. or exposure increase gene HO-1, NQO-1 Nrf2 These findings suggested signaling pathway may have contributed exercise-induced partial attenuation Cd-induced hepatic injury. also promoted occludin Cd-exposed decreasing structural inflammatory cell infiltration induced NF-κB TLR2 were elevated However, mitigated Cd-intoxicated suggesting protective effects intestinal tract be mediated through modulation NF-κB/TLR2 pathway. conclusion, this study elucidated against injury mice. mechanisms partially realized regulation pathways.

Язык: Английский

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Melatonin Repairs the Lipidome of Human Hepatocytes Exposed to Cd and Free Fatty Acid‐Induced Lipotoxicity

Journal of Pineal Research, Год журнала: 2025, Номер 77(3)

Опубликована: Апрель 1, 2025

ABSTRACT Hepatocyte lipotoxicity is central to the aetiology of nonalcoholic fatty liver disease (NAFLD), a leading cause failure and transplantation worldwide. Long‐lasting toxic pollutants have increasingly been considered as environmental risk factors NAFLD. These include cadmium (Cd), metal that synergizes with other cellular toxicants metabolic stimuli induce fat build‐up lipotoxicity. Recent studies demonstrated melatonin (MLT) holds great potential repairing agent in this form hepatocyte In study, molecular hints MLT effect were investigated by lipidomics analysis undifferentiated HepaRG cells, human pre‐hepatocyte cell line, exposed Cd toxicity either alone or combined prototypical free acids (FFA), namely saturated species palmitic acid monounsaturated oleic (OA PA, respectively), simulate conditions disease. exposure synergized FFAs steatosis, PA produced higher levels compared OA increased H 2 O production apoptotic death. effects associated changes lipidome, which approximate those NAFLD liver, differentially expressed lipids different classes included triacylglycerols (TG), di‐ mono‐acylglycerols, phospholipids (PL), sphingolipids, acylcarnitines FA; characteristic differences observed all these comparing combinations treatments. significantly reduced individual combinatorial treatments on hallmarks, also most alterations including chain length number double bonds acyl residues esterified TG PL classes. findings their bioinformatics interpretation suggest role for earliest elongase desaturase steps FA metabolism MLT; biochemistry validated such identifying specific SCD1 activity. This study shed light cytoprotective mechanism FFA‐induced lipotoxicity, highlighting molecule may hold therapeutic diseases.

Язык: Английский

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Modulation of Metabolic Pathways and Protection against Cadmium-Induced Disruptions with Taxifolin-Enriched Extract

ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Янв. 9, 2024

Cadmium, a ubiquitous environmental pollutant, has been implicated in the disruption of various metabolic pathways, contributing to development insulin resistance, glucose intolerance, and associated disorders. This study aimed investigate cadmium chloride (CdCl2) exposure on pathways assess potential therapeutic efficacy taxifolin-enriched extract mitigating these disruptions by modulating biochemical pathways. Taxifolin-enriched (TEE) was prepared from Pinus roxburghii bark using green extraction method. About 60 Wistar albino rats were divided into six groups: control group (n = 10), CdCl2 (30 mg/kg) four groups (each comprises n 10) treated with 30 mg/kg combination metformin (100 mg/kg), ascorbic acid, taxifolin TEE respectively. After treatment period 1 month, comprehensive assessment biomarkers gene expressions that regulate metabolism carbohydrates lipids conducted evaluate impact protective effects TEE. The results revealed significantly increased (P < 0.001) serum levels α-glucosidase, α-amylase, insulin, G6PC, hexokinases, TGs, LDL, HMG-CoA reductase, pro-inflammatory cytokines such as IL-6 TNF-α. Conversely, led reduction HDL, antioxidant enzyme levels, phosphofructokinases, glucose-6-phosphatase dehydrogenase. However, administration alongside substantially mitigated fluctuations inflammatory biomarker induced exposure. Both effectively lowered elevated leptin, ALT, AST, blood urea nitrogen, creatinine, while simultaneously enhancing HDL cholesterol enzymes. Moreover, suppressed mRNA expression critical transporter 2 (GLUT2), insulin-like growth factor (IGF-1), lactate dehydrogenase, lyases upregulating angiotensin receptor vasopressin, key involved regulation. demonstrated restore normal functions reduce adverse impacts caused disturbances several restoring related Nevertheless, further investigation is warranted comprehensively understand underlying mechanisms optimize appropriate dosage duration for achieving most effective outcomes.

Язык: Английский

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Subacute cadmium exposure changes different metabolic functions, leading to type 1 and 2 diabetes mellitus features in female rats

Environmental Toxicology, Год журнала: 2024, Номер 39(9), С. 4278 - 4297

Опубликована: Май 7, 2024

Abstract Cadmium (Cd) is a heavy metal that acts as endocrine disrupting chemical (EDC). Few studies have investigated the effects of Cd exposure on metabolic dysfunctions, such type 1 and 2 diabetes mellitus (T1DM T2DM). Thus, we assessed whether subacute at occupational levels causes abnormalities in white adipose tissue (WAT), liver, pancreas, skeletal muscle. We administered cadmium chloride (CdCl ) (100 ppm drinking water for 30 days) to female rats evaluated serum organs, morphophysiology, inflammation, oxidative stress, fibrosis, gene expression. High were found serum, WAT, Cd‐exposed showed low adiposity, dyslipidemia, insulin resistance, systemic stress compared controls. reduced adipocyte size, hyperleptinemia, increased cholesterol levels, apoptosis fibrosis WAT. had liver receptor beta (IRβ) peroxisome proliferator‐activated receptor‐gamma coactivator‐1alpha (PGC1α) expression, karyomegaly, fibrosis. pancreatic islet size inflammation muscle fiber diameter IR expression inflammation. Finally, strong positive correlations observed between abnormal morphology, these data suggest impairs pancreas function, leading T1DM T2DM features other complications rats.

Язык: Английский

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Melatonin as a Repairing Agent in Cadmium- and Free Fatty Acid-Induced Lipotoxicity

Biomolecules, Год журнала: 2023, Номер 13(12), С. 1758 - 1758

Опубликована: Дек. 7, 2023

(1) Background: Cadmium (Cd) is a potentially toxic element with long half-life in the human body (20–40 years). Cytotoxicity mechanisms of Cd include increased levels oxidative stress and apoptotic signaling, recent studies have suggested that these aspects toxicity contribute role pathobiology non-alcoholic fatty liver disease (NAFLD), highly prevalent ailment associated hepatic lipotoxicity an generation reactive oxygen species (ROS). In this study, its interplay acid (FA)-induced been studied intestinal epithelium cells; cytoprotective function melatonin (MLT) has also evaluated. (2) Methods: cells (HepaRG), primary murine hepatocytes Caco-2 epithelial were exposed to CdCl2 before after induction oleic (OA) and/or palmitic (PA), some experiments, FA was combined MLT (50 nM) treatment. (3) Results: ROS reduced cell viability both cells. synergized induce lipid droplet formation production; latter higher for PA compared OA cells, resulting reduction viability, especially HepaRG hepatocytes, whereas CACO-2 showed resistance Cd/PA-induced significant protection against either considered alone or FFA-induced (4) Conclusions: combine their pro-oxidant activity cellular populations gut–liver axis. can be used lessen synergistic effect Cd-PA on formation.

Язык: Английский

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