Curcumin Treatment Ameliorates Hepatic Insulin Resistance Induced by Sub-chronic Oral Exposure to Cadmium LOAEL Dose via NF-κB and Nrf2 Pathways

Biological Trace Element Research, Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Abstract Cadmium (Cd) is a global pollutant, and its accumulation in the liver causes oxidative stress, inflammation, insulin resistance (IR), metabolic complications. This study investigated whether curcumin treatment could alleviate hepatic IR Wistar rats exposed to sub-chronic cadmium explored underlying molecular pathways. Male were divided into control group (standard normocaloric diet + cadmium-free water) drinking water with 32.5 ppm CdCl 2 ) for 30 days. Oral glucose tolerance, response, assessed using mathematical models. Liver tissue was analyzed markers of key regulatory pathways, including NF-κB, Nrf2, MAPKs (JNK p38), IRS1-Akt pathway. We established an effective dose 250 mg/kg 5 days orally. Results demonstrated that after exposure, accumulated liver, inducing inflammatory state. characterized by increased expression JNK, p38, along diminished Nrf2 expression, IR, hyperglycemia, hyperinsulinemia. Curcumin effectively alleviated these disorders restoring balance between NF-κB modulating MAPK pathway, and, consequently, improving balance. In conclusion, this suggests induces through imbalance signaling appears improve thereby ameliorating IR.

Язык: Английский

---

Pancreatic Antioxidative Defense and Heat Shock Proteins Prevent Islet of Langerhans Cell Death After Chronic Oral Exposure to Cadmium LOAEL Dose

Biological Trace Element Research, Год журнала: 2023, Номер 202(8), С. 3714 - 3730

Опубликована: Ноя. 13, 2023

Язык: Английский

---

Inflammation as a pathway for heavy metal-induced liver damage—Insights from a repeated-measures study in residents exposed to metals and bioinformatics analysis

International Journal of Hygiene and Environmental Health, Год журнала: 2024, Номер 261, С. 114417 - 114417

Опубликована: Июль 4, 2024

Язык: Английский

---

Pollution and pancreas

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 65 - 84

Опубликована: Янв. 1, 2024

Язык: Английский

---

Chronic cadmium exposure to minimal-risk doses causes dysfunction of epididymal adipose tissue and metabolic disorders

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 495, С. 117203 - 117203

Опубликована: Дек. 18, 2024

Язык: Английский

---