Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 7, 2023
Abstract
Background:
Systemic
Immune
Inflammatory
Index
(SII)
is
a
novel
indicator
of
inflammation.
However,
no
studies
have
reported
the
effect
SII
on
association
between
metals
and
total
fat
(TOFAT).
We
aim
to
investigate
mediated
relationship
urinary
TOFAT
in
US
adult
population.
Methods:
This
cross-sectional
study
was
conducted
among
adults
with
complete
information
SII,
urine
metal
concentrations,
from
2011-2018
National
Health
Nutrition
Examination
Survey
(NHANES).
Multifactorial
logistic
regression
restricted
cubic
splines
were
used
explore
levels
TOFAT.
Furthermore,
serial
mediation
analyses
mediating
Results:
A
3324
subjects
included
this
study.
After
adjusting
for
covariates,
arsenic
(As),
cadmium
(Cd),
cobalt
(Co),
cesium
(Cs),
inorganic
mercury
(Hg),
molybdenum
(Mo),
manganese
(Mn),
lead
(Pb),
antimony
(Sb)
had
negative
significant
decreased
trends
odds
ratios
(all
P
trend
<
0.05).
In
population,
we
found
that
Cd,
Co,
Tu
positive
[
β
=
34.67
(95%CI:
1.65,
67.70);
54.49
12.20,
96.78);
29.46
1.67,
57.24)],
whereas
As
Hg
SII.
The
results
analysis
showed
effects
associations
Co
TOFAT,
beta
coefficient
0.8%
0.2,
0.5%;
0.020).
not
statistically
As,
>
Conclusions:
Our
findings
suggested
exposure
would
directly
decrease
level
increase
completely
by
which
mainly
exerted
females
rather
than
males.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Ноя. 14, 2024
Background
The
Klotho
gene
is
implicated
in
suppressing
aging
phenotypes
and
influencing
age-related
diseases.
Previous
studies
have
delved
into
its
connection
with
different
diseases,
yet
the
association
between
hearing
loss
has
rarely
been
examined.
A
recent
population
study
explored
relationship
serum
loss,
but
it
had
certain
limitations.
This
aims
to
analyze
link
α-Klotho
levels
thresholds,
as
well
risk
of
loss.
Methods
total
1,762
adults
aged
40–69
years
were
selected
from
2011–2012
National
Health
Nutrition
Examination
Survey
(NHANES).
Data
on
audiometry,
levels,
relevant
covariates
gathered.
Statistical
analyses,
including
linear
logistic
regression,
assessed
relationships
outcomes.
Results
Increased
correlated
diminished
thresholds
a
lower
Quartile
analysis
revealed
significant
trend,
where
elevated
linked
better
auditory
Adjusted
models
controlled
for
various
covariates,
affirming
robustness
findings.
Non-linear
associations
not
observed.
Conclusion
provided
novel
evidence
negative
impairment
40–69.
Our
results
suggested
protective
role
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 7, 2023
Abstract
Background:
Systemic
Immune
Inflammatory
Index
(SII)
is
a
novel
indicator
of
inflammation.
However,
no
studies
have
reported
the
effect
SII
on
association
between
metals
and
total
fat
(TOFAT).
We
aim
to
investigate
mediated
relationship
urinary
TOFAT
in
US
adult
population.
Methods:
This
cross-sectional
study
was
conducted
among
adults
with
complete
information
SII,
urine
metal
concentrations,
from
2011-2018
National
Health
Nutrition
Examination
Survey
(NHANES).
Multifactorial
logistic
regression
restricted
cubic
splines
were
used
explore
levels
TOFAT.
Furthermore,
serial
mediation
analyses
mediating
Results:
A
3324
subjects
included
this
study.
After
adjusting
for
covariates,
arsenic
(As),
cadmium
(Cd),
cobalt
(Co),
cesium
(Cs),
inorganic
mercury
(Hg),
molybdenum
(Mo),
manganese
(Mn),
lead
(Pb),
antimony
(Sb)
had
negative
significant
decreased
trends
odds
ratios
(all
P
trend
<
0.05).
In
population,
we
found
that
Cd,
Co,
Tu
positive
[
β
=
34.67
(95%CI:
1.65,
67.70);
54.49
12.20,
96.78);
29.46
1.67,
57.24)],
whereas
As
Hg
SII.
The
results
analysis
showed
effects
associations
Co
TOFAT,
beta
coefficient
0.8%
0.2,
0.5%;
0.020).
not
statistically
As,
>
Conclusions:
Our
findings
suggested
exposure
would
directly
decrease
level
increase
completely
by
which
mainly
exerted
females
rather
than
males.
