The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset DOI Creative Commons
Jun-feng Nie,

Dengqiu Lu,

Cong Zhang

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 7, 2023

Abstract Background: Systemic Immune Inflammatory Index (SII) is a novel indicator of inflammation. However, no studies have reported the effect SII on association between metals and total fat (TOFAT). We aim to investigate mediated relationship urinary TOFAT in US adult population. Methods: This cross-sectional study was conducted among adults with complete information SII, urine metal concentrations, from 2011-2018 National Health Nutrition Examination Survey (NHANES). Multifactorial logistic regression restricted cubic splines were used explore levels TOFAT. Furthermore, serial mediation analyses mediating Results: A 3324 subjects included this study. After adjusting for covariates, arsenic (As), cadmium (Cd), cobalt (Co), cesium (Cs), inorganic mercury (Hg), molybdenum (Mo), manganese (Mn), lead (Pb), antimony (Sb) had negative significant decreased trends odds ratios (all P trend < 0.05). In population, we found that Cd, Co, Tu positive [ β = 34.67 (95%CI: 1.65, 67.70); 54.49 12.20, 96.78); 29.46 1.67, 57.24)], whereas As Hg SII. The results analysis showed effects associations Co TOFAT, beta coefficient 0.8% 0.2, 0.5%; 0.020). not statistically As, > Conclusions: Our findings suggested exposure would directly decrease level increase completely by which mainly exerted females rather than males.

Язык: Английский

The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample DOI Creative Commons
Siyuan Wang, Wen Sun, Chan Ding

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Ноя. 14, 2024

Background The Klotho gene is implicated in suppressing aging phenotypes and influencing age-related diseases. Previous studies have delved into its connection with different diseases, yet the association between hearing loss has rarely been examined. A recent population study explored relationship serum loss, but it had certain limitations. This aims to analyze link α-Klotho levels thresholds, as well risk of loss. Methods total 1,762 adults aged 40–69 years were selected from 2011–2012 National Health Nutrition Examination Survey (NHANES). Data on audiometry, levels, relevant covariates gathered. Statistical analyses, including linear logistic regression, assessed relationships outcomes. Results Increased correlated diminished thresholds a lower Quartile analysis revealed significant trend, where elevated linked better auditory Adjusted models controlled for various covariates, affirming robustness findings. Non-linear associations not observed. Conclusion provided novel evidence negative impairment 40–69. Our results suggested protective role

Язык: Английский

Процитировано

1

The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset DOI Creative Commons
Jun-feng Nie,

Dengqiu Lu,

Cong Zhang

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 7, 2023

Abstract Background: Systemic Immune Inflammatory Index (SII) is a novel indicator of inflammation. However, no studies have reported the effect SII on association between metals and total fat (TOFAT). We aim to investigate mediated relationship urinary TOFAT in US adult population. Methods: This cross-sectional study was conducted among adults with complete information SII, urine metal concentrations, from 2011-2018 National Health Nutrition Examination Survey (NHANES). Multifactorial logistic regression restricted cubic splines were used explore levels TOFAT. Furthermore, serial mediation analyses mediating Results: A 3324 subjects included this study. After adjusting for covariates, arsenic (As), cadmium (Cd), cobalt (Co), cesium (Cs), inorganic mercury (Hg), molybdenum (Mo), manganese (Mn), lead (Pb), antimony (Sb) had negative significant decreased trends odds ratios (all P trend < 0.05). In population, we found that Cd, Co, Tu positive [ β = 34.67 (95%CI: 1.65, 67.70); 54.49 12.20, 96.78); 29.46 1.67, 57.24)], whereas As Hg SII. The results analysis showed effects associations Co TOFAT, beta coefficient 0.8% 0.2, 0.5%; 0.020). not statistically As, > Conclusions: Our findings suggested exposure would directly decrease level increase completely by which mainly exerted females rather than males.

Язык: Английский

Процитировано

0