Assessment of Heavy Metal Contamination Risk in Dry Fish from India: A Comprehensive Study

Food Control, Год журнала: 2024, Номер 167, С. 110804 - 110804

Опубликована: Авг. 13, 2024

Язык: Английский

---

Editorial: The role of oxidative stress in metabolic and inflammatory diseases

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Фев. 8, 2024

Citation: Klisic A, Ahmad R, Haddad D, Bonomini F and Sindhu S (2024) Editorial: The role of oxidative stress in metabolic inflammatory diseases. Front. Endocrinol. 15:1374584. doi: 10.3389/fendo.2024.1374584

Язык: Английский

---

Cadmium exposure causes transcriptomic dysregulation in adipose tissue and associated shifts in serum metabolites

Environment International, Год журнала: 2024, Номер 185, С. 108513 - 108513

Опубликована: Фев. 17, 2024

Cadmium (Cd) is a toxic heavy metal found in natural and industrial environments. Exposure to Cd can lead various metabolic disturbances, notably disrupting glucose lipid homeostasis. Despite this recognition, the direct impact of exposure on metabolism within adipose tissue, mechanisms underlying these effects, have not been fully elucidated. In study, we that accumulates tissues mice subjected exposure. Intriguingly, itself did induce significant alterations tissue under normal conditions. However, when cold stimulation, several notable changes were observed exposed Cd, including reduction drop body temperature, decrease size inguinal white (WAT), an increase expression thermogenic genes UCP1 PRDM16. These results indicate might enhance responsiveness external stimuli energy expenditure tissue. RNA-seq analysis further revealed altered gene profiles, particularly affecting peroxisome proliferator-activated receptor (PPAR)-mediated pathways, promoting remodeling resulting depletion lipids stored for energy. Non-targeted metabolomic mouse serum showed significantly disrupted metabolites increased fatty acid triglyceride levels. Correspondingly, population-level data confirmed association between elevated levels total cholesterol, triglycerides, low-density lipoprotein cholesterol. summary, provide substantial evidence molecular events induced by are relevant regulation Our findings suggest effects adipocyte functionality, positioning as critical target diseases from

Язык: Английский

---

Effects of Various Heavy Metal Exposures on Insulin Resistance in Non-diabetic Populations: Interpretability Analysis from Machine Learning Modeling Perspective

Biological Trace Element Research, Год журнала: 2024, Номер 202(12), С. 5438 - 5452

Опубликована: Фев. 26, 2024

Язык: Английский

---

Associations of heavy metals and urinary sodium excretion with obesity in adults: A cross-sectional study from Korean Health Examination and Nutritional Survey

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317190 - e0317190

Опубликована: Янв. 31, 2025

Sodium and heavy metals are among the key elements to which humans exposed due environmental pollution food consumption. Investigating association between metals, urinary sodium excretion, obesity is of significant importance, given potential implications for public health. Therefore, this study aims explore relationship overweight in Korean population. Data from 6,609 participants Korea National Health Nutrition Examination Survey (KNHANES) 2008 2012 were analyzed. Associations (cadmium, mercury), arsenic, excretion levels, overweight/obesity assessed using polytomous logistic regression models, adjusting confounders. Higher mercury (OR = 1.57, 95% CI 1.31-1.88) 2.21, 1.84-2.66) levels associated with an increased risk obesity. Notably, elevated both had highest odds being 3.61, 2.61-5.00). In contrast, other such as serum cadmium not statistically significantly This finding highlights intricate multiplicative effect on obesity, necessitating further research validate understand connections. Heavy particularly mercury, exert influence possibility enhanced impact especially when acting conjunction salt, indicated.

Язык: Английский

---

Geographical Variations in Metal Exposure and Its Impact on Metabolic Disorders and Hypertension: An Analysis of Chile's 2016–17 National Health Survey

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Background Evidence suggests that even low-level exposure to metals may disrupt metabolic pathways, contributing disorders. Local environmental factors modulate these effects, emphasizing the importance of territorial disaggregation. This population-based study evaluated geographic variations in four and their associations with obesity, diabetes, syndrome, hypertension Chile. Method Data from 3,822 participants National Health Survey 2016 2017 were analyzed. Biomarkers included inorganic arsenic, cadmium, mercury urine, lead serum. Metal was classified according 50th percentile distribution. Spatial simultaneous autoregressive models accounted for regional disaggregation spatial dependencies, adjusting age, sex, socioeconomic status, smoking. Analyses conducted at national subnational levels, incorporating sampling weights survey complex design. Results A total 42.4% individuals exposed 13.6% lead, 1.7% cadmium. Regional analysis revealed elevated arsenic northern regions (e.g., Arica Antofagasta), peaking 29.9%. At level, adjusted no significant between metal However, geographical linked overweight obesity across most areas diabetes syndrome northern, southernmost, central zones. Mercury associated all conditions macrozone, whereas cadmium exclusively southern regions. Conclusion These findings underscore critical differences metalloid disorders, highlighting need geographically targeted public health interventions consider local contextual factors. Trial registration Not applicable

Язык: Английский

---

Electronic Cigarette-Derived Metals: Exposure and Health Risks in Vapers

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Despite the popularity of electronic cigarettes (e-cigs) among adolescent and youth never-smokers adult smokers seeking a less harmful substitute for tobacco cigarettes, long-term health impact vaping is largely unknown. Biochemical, molecular, toxicological analyses biospecimens from e-cig users as well assays in relevant vitro models silico studies can identify chemical constituents emissions that may contribute to disease-causing potential vaping. E-cig aerosol contains wide range toxic carcinogenic compounds, which metals are particular concern. This due known or suspected role various pathogenesis numerous diseases. Many metalloids (herein referred "metals") have been detected liquid (e-liquid) and/or cells, tissues, biofluids, other specimens users. Metals contaminate ingredients e-liquid corrode internal components device. also be directly aerosolized surface heating element parts Inhalation metal habitual vapers nonusers through secondary exposure increase body burden chemicals. review summarizes state research on e-cig-derived their contributions estimated risks Highlighting composition aerosol, it focuses contents inhaled associated with this exposure. Emphasis placed adolescents who vulnerable populations bear disproportionate risk harm products. The gaps knowledge, methodological challenges, opportunities ahead discussed. importance translating findings into actionable information used regulation manufacturing products underscored.

Язык: Английский

---

Physiological Adaptations of Vigna radiata to Heavy Metal Stress: Soluble Sugar Accumulation and Biomass Enhancement

Plants, Год журнала: 2025, Номер 14(8), С. 1191 - 1191

Опубликована: Апрель 11, 2025

Background: Heavy metal contamination significantly threatens crop growth and global food security. Understanding plant responses to such stress is crucial developing stress-tolerant crops. This study explores the physiological biochemical of Vigna radiata (L.) R. Wilczek mercury, lead, copper stress, focusing on role soluble sugar accumulation biomass enhancement in conferring heavy tolerance. Methods: Commercially available V. seeds were exposed varying concentrations (50, 150, 300 mg/L) mercurous nitrate, lead chloride under controlled conditions. The germination rates, seedling growth, parameters as protein content analyzed using spectrophotometry statistical methods, including ANOVA. Results: results demonstrated that ion increased dry weight, while all tested metals promoted accumulation. Although inhibited at higher concentrations, exhibited strong tolerance moderate levels. Conclusion: highlights adaptive strategies radiata, soluble-sugar-mediated osmotic adjustment enhanced allocation, which contribute its resilience stress. These findings provide insights for breeding stress-resistant crops managing heavy-metal-contaminated environments.

Язык: Английский

---

Cumulative environmental exposures and metabolic syndrome: A study of heavy metals and volatile organic compounds

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 297, С. 118238 - 118238

Опубликована: Апрель 25, 2025

Язык: Английский

---

Investigating the Influence of Heavy Metals and Environmental Factors on Metabolic Syndrome Risk Based on Nutrient Intake: Machine Learning Analysis of Data from the Eighth Korea National Health and Nutrition Examination Survey (KNHANES)

Nutrients, Год журнала: 2024, Номер 16(5), С. 724 - 724

Опубликована: Март 2, 2024

This study delves into the complex interrelations among nutrient intake, environmental exposures (particularly to heavy metals), and metabolic syndrome. Utilizing data from Korea National Health Nutrition Examination Survey (KNHANES), machine learning techniques were applied analyze associations in a cohort of 5719 participants, categorized four distinct intake phenotypes. Our findings reveal that different patterns are associated with varying levels metal exposure health outcomes. Key include significant variations (Pb, Hg, Cd, Ni) across clusters, certain clusters showing heightened specific metals. These profiles, including differences obesity, diabetes prevalence, hypertension, cholesterol levels. Notably, Cluster 3, characterized by high-energy nutrient-rich diets, showed highest Pb Hg had most concerning indicators. Moreover, highlights impact lifestyle habits, such as smoking eating out, on phenotypes risks. Physical activity emerged critical factor, its absence linked imbalanced clusters. In conclusion, our research underscores intricate connections diet, factors, health. The emphasize need for tailored interventions policies consider these interplays, potentially informing future strategies combat syndrome related issues.

Язык: Английский

---