Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 28, 2025

Introduction Microplastics and nanoplastics are prevalent environmental contaminants. Recent reports indicate that polystyrene nanoparticles may adversely impact male reproductive health. This study aims to examine the effects of exposure on sperm metabolism development pre-implantation embryos. Methods In this study, C57BL/6 mice were orally gavage-administered (60 nm, 20 mg/kg/day) for 35 days assess their reproduction early embryonic development. Experiments included testicular transcriptome analysis, metabolomics, motility fertilization assays, ROS detection, RNA sequencing 2-cell embryos, revealing adverse embryo Results The results revealed oral gavage induced a pronounced immune-inflammatory response in tissue, reduced motility, significantly lowered rate. Notably, from treated exhibited substantial metabolic disruptions, affecting key pathways, including glycerophospholipid biosynthesis DNA repair. After fertilization, embryos at stage suffered damage apoptotic repair subsequently impairing Discussion conclusion, demonstrated administration affects function, resulting abnormalities alterations associated gene expression profiles. These findings offer essential scientific insights future research into sperm-mediated transgenerational

Язык: Английский

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Toxic Effects of Immunofluorescent Polystyrene Nanoplastics on Rat Testicular Tissue

Bratislavské lekárske listy/Bratislava medical journal, Год журнала: 2025, Номер unknown

Опубликована: Июнь 4, 2025

Abstract Background and Aim Nanoplastics (NPs), formed by the degradation of plastic materials, are ubiquitous substances with potential negative effects on various ecosystems organisms. This article aims to investigate toxicological biochemical NP accumulation in testicular tissue rats explore its male reproductive health. Methods Our study was conducted control (sham) group two experimental groups receiving 25 mg/kg NPs (LNp) 50 (HNp). Five each were administered fluorescent via gavage for one month. At end experiment, tissues removed, accumulation, oxidative stress inflammation investigated histopathologically biochemically. Results detected LNp HNp groups. Immature sperm cells vacuolization observed, suggesting that spermatogenesis adversely affected. Oxidative found be increased tissue. Toll-like receptor 7 (TLR7) gene expression evaluated, statistically significant (p < 0.05). Conclusion In conclusion, continuous intake nanoplastics can lead their tissue, impairing function potentially causing infertility. Given increasing presence environment, pose risks health, necessitating further research regulatory action minimize exposure.

Язык: Английский

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Investigating the effects of microplastics on the metabolism of TREMATOMUS BERNACCHII from the ross sea (Antarctica)

The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 176766 - 176766

Опубликована: Окт. 11, 2024

Язык: Английский

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Omics Insights in Responses of Bivalves Exposed to Plastic Pollution

Aquatic Toxicology, Год журнала: 2024, Номер 279, С. 107224 - 107224

Опубликована: Дек. 28, 2024

Язык: Английский

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