Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 28, 2025

Introduction Microplastics and nanoplastics are prevalent environmental contaminants. Recent reports indicate that polystyrene nanoparticles may adversely impact male reproductive health. This study aims to examine the effects of exposure on sperm metabolism development pre-implantation embryos. Methods In this study, C57BL/6 mice were orally gavage-administered (60 nm, 20 mg/kg/day) for 35 days assess their reproduction early embryonic development. Experiments included testicular transcriptome analysis, metabolomics, motility fertilization assays, ROS detection, RNA sequencing 2-cell embryos, revealing adverse embryo Results The results revealed oral gavage induced a pronounced immune-inflammatory response in tissue, reduced motility, significantly lowered rate. Notably, from treated exhibited substantial metabolic disruptions, affecting key pathways, including glycerophospholipid biosynthesis DNA repair. After fertilization, embryos at stage suffered damage apoptotic repair subsequently impairing Discussion conclusion, demonstrated administration affects function, resulting abnormalities alterations associated gene expression profiles. These findings offer essential scientific insights future research into sperm-mediated transgenerational

Language: Английский

Investigating the effects of microplastics on the metabolism of TREMATOMUS BERNACCHII from the ross sea (Antarctica)

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 176766 - 176766

Published: Oct. 11, 2024

Language: Английский

Omics Insights in Responses of Bivalves Exposed to Plastic Pollution

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 279, P. 107224 - 107224

Published: Dec. 28, 2024

Language: Английский