Ecotoxicological Risk Assessment of the Novel Psychoactive Substance Esketamine: Emphasis on Fish Skeletal, Behavioral, and Vascular Development
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
480, С. 135823 - 135823
Опубликована: Сен. 11, 2024
Язык: Английский
The impact of esketamine on cardiac function in patients undergoing anesthesia
Exploration of Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Esketamine,
the
S-enantiomer
of
ketamine,
has
gained
prominence
as
an
adjunct
in
pain
management
during
general
anesthesia
due
to
its
higher
potency
and
ability
achieve
therapeutic
effects
at
lower
doses
than
ketamine.
While
benefits
for
relief
mental
health
are
well-established,
specific
esketamine
on
cardiac
function
remain
under
investigation.
Anesthesia
itself
induces
physiological
changes
cardiovascular
system,
can
exacerbate
these
by
increasing
sympathetic
activity,
heart
rate,
blood
pressure,
output.
Additionally,
it
induce
peripheral
vasoconstriction,
raising
systemic
vascular
resistance.
These
particularly
concerning
patients
with
pre-existing
conditions,
underscoring
importance
preoperative
assessment,
continuous
monitoring,
potential
dose
adjustments.
This
review
examined
hemodynamic
esketamine,
associated
risks,
clinical
implications
offering
recommendations
safe
use
anesthesia.
Язык: Английский
New Psychoactive Substance Esketamine Causes Endocrine-Disrupting Effects and Developmental Toxicity
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Esketamine
(ESK),
a
new
psychoactive
substance
known
for
its
strong
hallucinogenic
effect,
has
been
detected
in
surface
water
worldwide.
The
toxicity
of
ESK
to
fish
at
certain
environmental
concentration
remains
unclear.
In
this
study,
zebrafish
embryos
and
ZF4
cells
were
exposed
(0,
0.12,
1.02,
10.6
μg
L-1,
marked
by
SC,
LC,
MC,
HC,
respectively)
14
days
post
fertilization
(dpf)
24
h,
respectively.
Biphasic
dose
responses
induced
observed
after
h
exposure.
ESK-LC
ESK-MC
obviously
increased
embryo
area
length,
height,
volume
yolk
sac,
whereas
ESK-HC
had
the
opposite
effect.
appreciably
upregulated
transcription
expression
levels
vtg,
disrupting
cell
cycle
After
dpf
exposure,
KEGG
analysis
indicated
that
circadian
rhythm,
nucleotide
excision
repair,
estrogen
signaling
pathways
top
three
impacted
pathways,
with
significantly
enhancing
gene
these
except
cyp7a1
bh1he41.
Correspondingly,
notably
VTG
level,
aligning
relatively
high
affinity
receptors,
as
analyzed
through
molecular
docking.
Our
research
demonstrated
exhibits
developmental
endocrine-disrupting
effects
zebrafish,
highlighting
need
address
ecological
fish.
Язык: Английский