New Psychoactive Substance Esketamine Causes Endocrine-Disrupting Effects and Developmental Toxicity DOI
Siying Li,

Dongdong Ma,

Wenjun Shi

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Esketamine (ESK), a new psychoactive substance known for its strong hallucinogenic effect, has been detected in surface water worldwide. The toxicity of ESK to fish at certain environmental concentration remains unclear. In this study, zebrafish embryos and ZF4 cells were exposed (0, 0.12, 1.02, 10.6 μg L-1, marked by SC, LC, MC, HC, respectively) 14 days post fertilization (dpf) 24 h, respectively. Biphasic dose responses induced observed after h exposure. ESK-LC ESK-MC obviously increased embryo area length, height, volume yolk sac, whereas ESK-HC had the opposite effect. appreciably upregulated transcription expression levels vtg, disrupting cell cycle After dpf exposure, KEGG analysis indicated that circadian rhythm, nucleotide excision repair, estrogen signaling pathways top three impacted pathways, with significantly enhancing gene these except cyp7a1 bh1he41. Correspondingly, notably VTG level, aligning relatively high affinity receptors, as analyzed through molecular docking. Our research demonstrated exhibits developmental endocrine-disrupting effects zebrafish, highlighting need address ecological fish.

Language: Английский

Ecotoxicological Risk Assessment of the Novel Psychoactive Substance Esketamine: Emphasis on Fish Skeletal, Behavioral, and Vascular Development DOI
Qiong Zhang,

Tianjie Wu,

Congying Luo

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135823 - 135823

Published: Sept. 11, 2024

Language: Английский

Citations

3
The impact of esketamine on cardiac function in patients undergoing anesthesia DOI Creative Commons

Edward Sun,

Yuxian Liu, Jingping Wang

et al.

Exploration of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Esketamine, the S-enantiomer of ketamine, has gained prominence as an adjunct in pain management during general anesthesia due to its higher potency and ability achieve therapeutic effects at lower doses than ketamine. While benefits for relief mental health are well-established, specific esketamine on cardiac function remain under investigation. Anesthesia itself induces physiological changes cardiovascular system, can exacerbate these by increasing sympathetic activity, heart rate, blood pressure, output. Additionally, it induce peripheral vasoconstriction, raising systemic vascular resistance. These particularly concerning patients with pre-existing conditions, underscoring importance preoperative assessment, continuous monitoring, potential dose adjustments. This review examined hemodynamic esketamine, associated risks, clinical implications offering recommendations safe use anesthesia.

Language: Английский

Citations

0
New Psychoactive Substance Esketamine Causes Endocrine-Disrupting Effects and Developmental Toxicity DOI
Siying Li,

Dongdong Ma,

Wenjun Shi

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Esketamine (ESK), a new psychoactive substance known for its strong hallucinogenic effect, has been detected in surface water worldwide. The toxicity of ESK to fish at certain environmental concentration remains unclear. In this study, zebrafish embryos and ZF4 cells were exposed (0, 0.12, 1.02, 10.6 μg L-1, marked by SC, LC, MC, HC, respectively) 14 days post fertilization (dpf) 24 h, respectively. Biphasic dose responses induced observed after h exposure. ESK-LC ESK-MC obviously increased embryo area length, height, volume yolk sac, whereas ESK-HC had the opposite effect. appreciably upregulated transcription expression levels vtg, disrupting cell cycle After dpf exposure, KEGG analysis indicated that circadian rhythm, nucleotide excision repair, estrogen signaling pathways top three impacted pathways, with significantly enhancing gene these except cyp7a1 bh1he41. Correspondingly, notably VTG level, aligning relatively high affinity receptors, as analyzed through molecular docking. Our research demonstrated exhibits developmental endocrine-disrupting effects zebrafish, highlighting need address ecological fish.

Language: Английский

Citations

0