The
production
and
application
of
nanomaterials
have
grown
tremendously
during
last
few
decades.
widespread
exposure
nanoparticles
to
the
public
is
provoking
great
concerns
regarding
their
toxicity
human
body.
However,
in
comparison
with
extensive
studies
carried
out
examine
nanoparticle
body/organs,
one
especially
vulnerable
organ,
eye,
always
neglected.
Although
it
a
small
part
body,
90%
outside
information
obtained
via
ocular
system.
In
addition,
eyes
usually
directly
interact
surrounding
environment,
which
may
get
severer
damage
from
toxic
compared
inner
organs.
Therefore,
study
assessing
potential
importance.
Here,
recent
advance
some
representative
manufactured
on
summarized.
First,
brief
introduction
anatomy
disorders
related
particulate
matter
presented.
Following,
factors
that
influence
eye
are
emphasized.
Next,
summarized
classified.
Finally,
limitations
associated
current
nanoparticle-eye
research
proposed.
Journal of Clinical Medicine,
Год журнала:
2018,
Номер
7(12), С. 490 - 490
Опубликована: Ноя. 27, 2018
Nanoparticles
are
zero-dimensional
nanomaterials
and,
based
on
their
nature,
they
can
be
categorized
into
organic,
inorganic,
and
composites
nanoparticles.
Due
to
unique
physical
chemical
properties,
nanoparticles
extensively
used
in
a
variety
of
fields,
including
medicine,
pharmaceutics,
food
industry.
Although
have
the
potential
improve
diagnosis
treatment
brain
diseases,
it
is
fundamentally
important
develop
standardized
toxicological
studies,
which
prevent
induction
neurotoxic
effects.
The
focus
this
review
emphasize
both
beneficial
negative
effects
health.
ACS Applied Bio Materials,
Год журнала:
2022,
Номер
5(4), С. 1391 - 1463
Опубликована: Март 31, 2022
The
substantial
increase
in
multidrug-resistant
(MDR)
pathogenic
bacteria
is
a
major
threat
to
global
health.
Recently,
the
Centers
for
Disease
Control
and
Prevention
reported
possibilities
of
greater
deaths
due
bacterial
infections
than
cancer.
Nanomaterials,
especially
small-sized
(size
≤10
nm)
silver
nanoparticles
(AgNPs),
can
be
employed
combat
these
deadly
diseases.
However,
high
reactivity,
instability,
susceptibility
fast
oxidation,
cytotoxicity
remain
crucial
shortcomings
their
uptake
clinical
application.
In
this
review,
we
discuss
various
AgNPs-based
approaches
eradicate
provide
comprehensive
mechanistic
insights
recent
advances
antibacterial
activity,
antibiofilm
(both
vitro
vivo)
AgNPs.
antimicrobial
activity
involves
four
steps:
(i)
adhesion
AgNPs
cell
wall/membrane
its
disruption;
(ii)
intracellular
penetration
damage;
(iii)
oxidative
stress;
(iv)
modulation
signal
transduction
pathways.
Numerous
factors
affecting
bactericidal
such
as
shape,
size,
crystallinity,
pH,
surface
coating/charge
have
also
been
described
detail.
review
sheds
light
on
photodynamic
therapy
role
versus
Ag+
ions
release
activities.
addition,
different
methods
synthesis
discussed
brief.
International Journal of Nanomedicine,
Год журнала:
2022,
Номер
Volume 17, С. 1851 - 1864
Опубликована: Апрель 1, 2022
Abstract:
Nano
silver
is
one
of
the
most
widely
used
engineering
nanomaterials
with
antimicrobial
activity
against
bacteria,
fungi,
and
viruses.
However,
widespread
application
nano
preparations
in
daily
life
raises
concerns
about
public
health.
Although
several
review
articles
have
described
toxicity
to
specific
major
organs,
an
updated
comprehensive
that
clearly
systematically
outlines
harmful
effects
lacking.
This
begins
routes
exposure
its
distribution
vivo.
The
toxic
reactions
are
then
discussed
on
three
levels,
from
organ
cellular
subcellular
levels.
also
provides
new
insights
adjusting
by
changing
their
size
surface
functionalization
combination
other
materials
form
a
composite
formulation.
Finally,
future
development,
challenges,
research
directions
discussed.
Graphical
Keywords:
silver,
routes,
distribution,
toxicity,
mechanism
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 695 - 695
Опубликована: Фев. 18, 2023
Modern
drug
discovery
methods
led
to
evolving
new
agents
with
significant
therapeutic
potential.
However,
their
properties,
such
as
solubility
and
administration-related
challenges,
may
hinder
benefits.
Moreover,
advances
in
biotechnology
resulted
the
development
of
a
generation
molecules
short
half-life
that
necessitates
frequent
administration.
In
this
context,
controlled
release
systems
are
required
enhance
treatment
efficacy
improve
patient
compliance.
Innovative
delivery
promising
tools
protect
proteins
peptides
against
proteolytic
degradation
where
is
achievable.
The
present
review
provides
an
overview
different
approaches
used
for
delivery.
Abstract
Nanotechnologies
have
been
advantageous
in
many
sectors
and
gaining
much
concern
due
to
the
unique
physical,
chemical
biological
properties
of
nanomaterials
(NMs).
We
surveyed
peer-reviewed
publications
related
“nanotechnology”,
“NMs”,
“NMs
water
treatment”,
air
environmental
risk”
last
23
years.
found
that
most
research
work
is
focused
on
developing
novel
applications
for
NMs
new
products
with
peculiar
features.
In
contrast,
there
are
relatively
few
concerning
as
contaminants
relative
applications.
Thus,
we
devoted
this
review
emerging
contaminants.
The
definition
classification
will
be
presented
first
demonstrate
importance
unifying
definition.
information
provided
here
should
facilitate
detection,
control,
regulation
environment.
high
surface-area-to-volume
ratio
reactivity
cause
prediction
potential
toxicities
NPs
extremely
difficult;
therefore,
marked
knowledge
gaps
fate,
impact,
toxicity,
risk
NMs.
Consequently,
modifying
extraction
methods,
detection
tools,
characterization
technologies
essential
complete
assessment
This
help
also
setting
regulations
standards
releasing
handling
no
specific
regulations.
Finally,
integrated
treatment
necessary
removal
water.
Also,
membrane
technology
recommended
remediation
air.
Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 703 - 703
Опубликована: Март 12, 2023
Emerging
nanoscience
allows
us
to
take
advantage
of
the
improved
evolutionary
components
and
apply
today’s
advanced
characterization
fabrication
techniques
solve
environmental
biological
problems.
Despite
promise
that
nanotechnology
will
improve
our
lives,
potential
risks
technology
remain
largely
uncertain.
The
lack
information
on
bio-impacts
absence
consistent
standards
are
limitations
using
metal-based
nanoparticles
(mNPs)
for
existing
applications.
To
analyze
role
played
by
mNPs
physicochemical
characteristics
tactics
protect
live
beings,
field
nanotoxicology
nowadays
is
focused
collecting
analyzing
data
from
in
vitro
vivo
investigations.
degree
reactive
oxygen
species
(ROS)
oxidative
stress
caused
material
(NPs)
depends
many
factors,
such
as
size,
shape,
chemical
composition,
etc.
These
enable
NPs
enter
cells
interact
with
macromolecules
cell
organelles,
resulting
damage,
an
inflammatory
response,
development
mitochondrial
dysfunction,
damage
genetic
material,
or
cytotoxic
effects.
This
report
explored
mechanisms
cellular
signaling
cascades
mNPs-induced
relevant
health
consequences.
Advanced Materials,
Год журнала:
2024,
Номер
36(26)
Опубликована: Апрель 11, 2024
Drug
delivery
is
a
key
component
of
nanomedicine,
and
conventional
relies
on
the
adsorption
or
encapsulation
drug
molecules
to
nanomaterial.
Many
vehicles
contain
metal
ions,
such
as
metal-organic
frameworks,
oxides,
transition
dichalcogenides,
MXene,
noble
nanoparticles.
These
materials
have
high
content
pose
potential
long-term
toxicity
concerns
leading
difficulties
for
clinical
approval.
In
this
review,
recent
developments
are
summarized
in
use
ligands
coordination
forming
various
nanomaterials
soft
materials.
these
cases,
drug-to-metal
ratio
much
higher
than
adsorption-based
strategies.
The
divided
into
small-molecule
drugs,
nucleic
acids,
proteins.
formed
hybrid
mainly
include
nanoparticles
hydrogels,
upon
which
targeting
can
be
grafted
improve
efficacy
further
decrease
toxicity.
application
addressing
cancer,
viral
infection,
bacterial
infection
inflammatory
bowel
disease,
bone
diseases
reviewed.
end,
some
future
directions
discussed
from
fundamental
research,
science,
medicine.
