Evaluation of pregnancy outcomes in mothers with COVID-19 infection: a systematic review and meta-analysis

Journal of Obstetrics and Gynaecology, Год журнала: 2023, Номер 43(1)

Опубликована: Янв. 18, 2023

Pregnant women are one of the endangered groups who need special attention in COVID-19 epidemic. We conducted a systematic review and summarised studies that reported adverse pregnancy outcomes pregnant with infection. A literature search was performed PubMed Scopus up to 1 September 2022, for retrieving original articles published English language assessing association between infection outcomes. Finally, this study, 1790 obtained initial search, 141 eligible including 1,843,278 were reviewed. also meta-analysis total 74 cohort case-control studies. In meta-analysis, both fixed random effect models used. Publication bias assessed by Egger's test trim fill method case significant result, adjust bias. The result showed pooled prevalence preterm delivery, maternal mortality, NICU admission neonatal death group significantly more than those without (p<.01). meta-regression using income level countries. during may cause death. Pregnancy loss SARS-CoV2 positive neonates Lower middle higher High income. Vertical transmission from mother foetus occur, but its immediate long-term effects on newborn unclear.

Язык: Английский

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The Risk of Spontaneous Abortion Does Not Increase Following First Trimester mRNA COVID-19 Vaccination

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(6), С. 1698 - 1698

Опубликована: Март 18, 2022

Clinical trials for COVID-19 vaccines initially excluded pregnant women due to safety concerns, and when the were authorized emergency use, they not recommended this population. However, observational studies discovered that infected with have higher risks of negative pregnancy delivery outcomes compared non-pregnant women, raising question risks-benefits administering women. By mid-2021, there was general consensus on relative vaccination during pregnancy; therefore, it is critical investigate issues related these vaccines, considering increasing acceptance among To address we developed a research project study short-term effects first trimester pregnancy. Our followed an retrospective design 12 months from beginning campaign, included 124 cases spontaneous abortions 927 ongoing pregnancies. The odds abortion non-significant both versions mRNA vaccine (Pfizer BNT162b2 AOR = 1.04, CI 0.91-1.12; Moderna mRNA-1273 1.02, 0.89-1.08). Overall, our data indicated risk after immunization commensurate predicted in non-vaccinated These findings contribute growing body information regarding

Язык: Английский

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Correlation between Pregnancy Outcome and Placental Pathology in COVID-19 Pregnant Women

Infectious Diseases in Obstetrics and Gynecology, Год журнала: 2022, Номер 2022, С. 1 - 5

Опубликована: Авг. 21, 2022

Background. Vertical transmission of several viruses during pregnancy has been shown to cause adverse fetal outcomes. The question about the possibility a similar outcome in association with SARS-CoV-2 raised recently published articles. Indeed, rate through placenta fetus reported women COVID-19 form minority. aim this study was explore possible histopathological changes pregnant after delivery and those umbilical cord. Methods. A case-control including total 50 full-term 60 control females. Histopathological evaluation placental tissues cords were reported. Results. main findings cord increased thickness vessels, thrombus formation, endothelins, narrow lumen; except for blood these more frequently seen COVID-19, comparison significant manner ( $p<0.05$ ). Increased vessels significantly observed group compared id="M2"> 0.01 Findings included avascular villi, fibrin, thrombosis, meconium macrophage various combinations. Except fibrin as sole findings, all other combinations encountered id="M3"> Conclusion. Pregnant have pathological alterations These reflect capability causing immunological reactions placenta, either directly or indirectly, pathologies may be linked higher neonatal outcomes maternal admission intensive care unit.

Язык: Английский

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The Heterogeneous Severity of COVID-19 in African Countries: A Modeling Approach

Bulletin of Mathematical Biology, Год журнала: 2022, Номер 84(3)

Опубликована: Янв. 24, 2022

The COVID-19 pandemic has had a considerable impact on global health and economics. in African countries not been investigated thoroughly via fitting epidemic models to the reported deaths. We downloaded data for 12 most-affected with highest cumulative deaths estimate time-varying basic reproductive number ( $${R}_{0}(t)$$ ) infection attack rate. develop simple model fitted it using iterated filtering allowing flexible transmission observe high heterogeneity case-fatality rate across countries, which may be due different reporting or testing efforts. South Africa, Tunisia, Libya were most affected, exhibiting relatively higher Thus, effectively control spread of epidemics there is need consider other mitigation strategies (such as improvements socioeconomic well-being, healthcare systems, water supply, awareness campaigns).

Язык: Английский

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Eastern India Collaboration on Multisystem Inflammatory Syndrome in Children (EICOMISC): A Multicenter Observational Study of 134 Cases

Frontiers in Pediatrics, Год журнала: 2022, Номер 10

Опубликована: Март 11, 2022

Few single center studies from resource-poor settings have reported about the epidemiology, clinical feature and outcome of multisystem inflammatory syndrome in children (MIS-C). However, larger data multi-center on same is lacking including Indian setting.This retrospective collaborative study constituted collected MIS-C five tertiary care teaching hospitals Eastern India. Children ≤ 15 years age with as per WHO criteria were included. Primary was mortality.A total 134 cases included (median age, 84 months; males 66.7%). Fever a universal finding. Rash present 40%, conjunctivitis 71% cases. Gastro-intestinal respiratory symptoms observed 50.7% 39.6% cases, respectively. Co-morbidity 23.9% Shock at admission noted 35%, 27.38% required mechanical ventilation. Fifteen (11.2%) died. The coronary abnormalities got normalized during follow-up all except one child. Initial choice immunomodulation had no effect outcomes. Presence underlying co-morbidity, lymphopenia, thrombocytosis, hyponatremia, increased LDH (>300 U/L), hypoalbuminemia factors significantly associated an mortality.MIS-C has myriad manifestations. Underlying mortality. No difference either steroid or IVIg both. Coronary artery resolved nearly

Язык: Английский

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SARS-CoV-2 Transplacental Transmission: A Rare Occurrence? An Overview of the Protective Role of the Placenta

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4550 - 4550

Опубликована: Фев. 25, 2023

The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel severe acute respiratory syndrome 2 (SARS-CoV-2), has resulted in a global public health crisis, causing substantial concern especially to pregnant population. Pregnant women infected with SARS-CoV-2 are at greater risk devastating pregnancy complications such as premature delivery and stillbirth. Irrespective emerging reported cases neonatal COVID-19, reassuringly, confirmatory evidence vertical transmission is still lacking. protective role placenta limiting utero spread virus developing fetus intriguing. short- long-term impact maternal COVID-19 infection newborn remains an unresolved question. In this review, we explore recent transmission, cell-entry pathways, placental responses towards infection, its potential effects on offspring. We further discuss how serves defensive front against exerting various cellular molecular defense pathways. A better understanding barrier, immune defense, modulation strategies involved restricting transplacental may provide valuable insights for future development antiviral immunomodulatory therapies improve outcomes.

Язык: Английский

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Tiny Lungs, Big Differences: Navigating the Varied COVID-19 Landscape in Neonates vs. Infants via Biomarkers and Lung Ultrasound

Biomedicines, Год журнала: 2024, Номер 12(2), С. 425 - 425

Опубликована: Фев. 13, 2024

Due to their susceptibilities, neonates and infants face unique SARS-CoV-2 challenges. This retrospective study will compare the illness course, symptoms, biomarkers, lung damage in with infection from February 2020 October 2023. was conducted at two hospitals Timisoara, Romania, using real-time multiplex PCR diagnose ultrasonography (LUS) assess involvement. Neonates had a more severe clinical presentation, an increased immune response, greater PCR-positive tests (p = 0.0089) longer hospital stays 0.0002). In neonates, LDH, CRP, ferritin levels were higher, indicating stronger inflammatory response. Reduced oxygen saturation indicates respiratory dysfunction. The symptoms varied. Infants fever, cough, rhinorrhea, while psychomotor agitation, acute dehydration syndrome, candidiasis. emphasizes individualized care close monitoring for neonatal infections. Newborn showed different variances severity levels, emphasizing need targeted surveillance therapy. Newborns have high ultrasound scores (LUSS), significant Both groups initial involvement, but understanding these modest differences is crucial improving vulnerable populations.

Язык: Английский

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Pregnancy Outcomes in the COVID-19 Era: An Observational Retrospective Study

Archives of Clinical Infectious Diseases, Год журнала: 2025, Номер 20(2)

Опубликована: Янв. 18, 2025

Background: There are ongoing controversies regarding pregnancy outcomes during the COVID-19 era. Objectives: This observational study with a retrospective design was conducted to investigate maternal and neonatal impacts of on outcomes. Methods: An carried out using census sampling from February 2020 July 2021. The population included pregnant women who were referred Asalian Hospital in Khorramabad city, western Iran. A total 769 mothers (107 662 without COVID-19) study. Results: most common symptoms reported by infected body pain/myalgia (68, 72.3%), fatigue (57, 60.6%), headache (47, 50%), shivering (46, 48.9%). After adjusting for covariates, risk caesarean section (CS) found be 3.2 times higher (95% confidence interval: 1.90 - 5.50). In contrast, risks newborn hospitalization, prematurity, low APGAR scores, respiratory distress, smaller head circumference among newborns non-COVID-19-infected than those COVID-19-infected (P < 0.05). Conclusions: While it is generally expected that would experience adverse outcomes, this demonstrated infection does not result or newborns, apart rate CS.

Язык: Английский

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SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Дек. 16, 2022

Pregnant women constitute one of the most vulnerable populations to be affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, cause disease 2019. SARS-CoV-2 infection during pregnancy could negatively impact fetal brain development via multiple mechanisms. Accumulating evidence indicates that mother fetus transmission does occur, albeit rarely. When it there is a potential for neuroinvasion immune cells, retrograde axonal transport, and olfactory bulb lymphatic pathways. In absence maternal transmission, still negative neurodevelopmental outcomes as consequence disrupted placental function leading preeclampsia, preterm birth, intrauterine growth restriction. addition, activation may lead hypomyelination, microglial activation, white matter damage, reduced neurogenesis in developing fetus. Moreover, can disrupt or hypothalamic-pituitary-adrenal (HPA) axis altered neurodevelopment. Finally, pro-inflammatory cytokines potentially alter epigenetic processes within brain. this review, we address each these We propose disorders subset pregnant long-term studies are warranted.

Язык: Английский

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SARS-CoV-2 infection and female reproductive health: A narrative review

Best Practice & Research Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 37(4), С. 101760 - 101760

Опубликована: Март 1, 2023

Язык: Английский

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