Bacterial coinfection and antibiotic resistance in hospitalized COVID-19 patients: a systematic review and meta-analysis DOI Creative Commons
Ruhana Che Yusof, Mohd Noor Norhayati,

Yacob Mohd Azman

и другие.

PeerJ, Год журнала: 2023, Номер 11, С. e15265 - e15265

Опубликована: Апрель 26, 2023

Background There were a few studies on bacterial coinfection in hospitalized COVID-19 patients worldwide. This systematic review aimed to provide the pooled prevalence of from published 2020 2022. Methods Three databases used search studies, and 49 2,451 identified involving 212,605 included this review. Results The random-effects inverse-variance model determined that was 26.84% (95% CI [23.85–29.83]). isolated bacteria for Acinetobacter baumannii 23.25% [19.27–27.24]), Escherichia coli 10.51% [8.90–12.12]), Klebsiella pneumoniae 15.24% [7.84–22.64]), Pseudomonas aeruginosa 11.09% [8.92–13.27]) Staphylococcus aureus (11.59% [9.71–13.46])). Meanwhile, antibiotic-resistant extended-spectrum beta-lactamases producing Enterobacteriaceae [7.84–22.64]) followed by carbapenem-resistant (14.55% [9.59–19.52%])), (6.95% [2.61–11.29])), methicillin-resistant (5.05% [3.49–6.60])), (4.95% [3.10–6.79])), vancomycin-resistant Enterococcus (1.26% [0.46–2.05])). Conclusion All prevalences considered as low. However, effective management prevention infection should be since these coinfections have bad impact morbidity mortality patients.

Язык: Английский

Antimicrobial peptides: Structure, mechanism, and modification DOI
Na Chen, Jiang Cheng

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 255, С. 115377 - 115377

Опубликована: Апрель 20, 2023

Язык: Английский

Процитировано

121
Antimicrobial Peptides: From Design to Clinical Application DOI Creative Commons
Chunye Zhang, Ming Yang

Antibiotics, Год журнала: 2022, Номер 11(3), С. 349 - 349

Опубликована: Март 6, 2022

Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, brings public health issues causes economic burden. Pathogenic bacteria develop several methods to resist antibiotic killing or inhibition, mutation function sites, activation drug efflux pumps, enzyme-mediated degradation. Antibiotic resistance components can be transferred between by mobile genetic elements including plasmids, transposons, integrons, well bacteriophages. The development limits the treatment options for bacterial infection, especially MDR bacteria. Therefore, novel alternative antibacterial agents are urgently needed. Antimicrobial peptides (AMPs) display multiple mechanisms against infections, directly bactericidal activity immunomodulatory function, potential alternatives antibiotics. In this review, resistance, AMPs, especially, design, optimization, delivery AMPs reviewed. Strategies structural change, amino acid substitution, conjugation with cell-penetration peptide, terminal acetylation amidation, encapsulation nanoparticles will improve antimicrobial efficacy, reduce toxicity, accomplish local AMPs. addition, clinical trials in AMP studies applications within last five years were summarized. Overall, diverse action infection pathogenic future research investigations accelerate application.

Язык: Английский

Процитировано

91
Epidemiology of Candidemia and Fluconazole Resistance in an ICU before and during the COVID-19 Pandemic Era DOI Creative Commons
Christina Routsi, Joseph Meletiadis,

Efstratia Charitidou

и другие.

Antibiotics, Год журнала: 2022, Номер 11(6), С. 771 - 771

Опубликована: Июнь 4, 2022

The objectives of this study were to investigate the incidence candidemia, as well factors associated with Candida species distribution and fluconazole resistance, among patients admitted intensive care unit (ICU) during COVID-19 pandemic, compared two pre-pandemic periods. All ICU due from March 2020 October 2021, periods (2005-2008 2012-2015), who developed included. During period, candidemia was 10.2%, significantly higher 3.2% 4.2% in periods, respectively. proportion non-albicans increased (from 60.6% 62.3% 75.8%, respectively), a predominance C. parapsilosis. A marked increase resistance 31% 37.7% 48.4%, respectively) also observed. Regarding total patient population (n = 205), independently length stay (LOS) before (OR 1.03; CI: 1.01-1.06, p 0.003), whereas presence shock at onset albicans 6.89; 2.2-25, 0.001), fluconazole-susceptible 0.23; 0.07-0.64, 0.006). In conclusion, substantial increases non-albicansCandida species, found COVID-19, At onset, prolonged LOS fluconazole-resistant species.

Язык: Английский

Процитировано

48
Changing Epidemiology of Respiratory Tract Infection during COVID-19 Pandemic DOI Creative Commons

Hung-Jen Tang,

Chih‐Cheng Lai, Chien‐Ming Chao

и другие.

Antibiotics, Год журнала: 2022, Номер 11(3), С. 315 - 315

Опубликована: Фев. 25, 2022

The outbreak of COVID-19 has significantly changed the epidemiology respiratory tract infection in several ways. implementation non-pharmaceutical interventions (NPIs) including universal masking, hand hygiene, and social distancing not only resulted a decline reported SARS-CoV-2 cases but also contributed to non-COVID-19 infection-related hospital utilization. Moreover, it led decreased incidence previous commonly encountered pathogens, such as influenza Streptococcus pneumoniae. Although antimicrobial agents are essential for treating patients with co-infection, prescribing antibiotics was higher than estimated prevalence bacterial which indicated overuse or unnecessary antibiotic use during pandemic. Furthermore, inappropriate exposure may drive selection drug-resistant microorganisms, disruption control setting measures result spread multidrug-resistant organisms (MDROs). In conclusion, NPIs could be effective preventing changing microbiologic distribution pathogens; however, we should continue epidemiological surveillance establish updated information, stewardship programs appropriate antibiotic, prevention prevent MDROs

Язык: Английский

Процитировано

43
Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic DOI Creative Commons
Alessia Catalano, Domenico Iacopetta, Jessica Ceramella

и другие.

Viruses, Год журнала: 2023, Номер 15(9), С. 1843 - 1843

Опубликована: Авг. 30, 2023

Antibacterial resistance is a renewed public health plague in modern times, and the COVID-19 pandemic has rekindled this problem. Changes antibiotic prescribing behavior, misinformation, financial hardship, environmental impact, governance gaps have generally enhanced misuse improper access to antibiotics during pandemic. These determinants, intersected with antibacterial current pandemic, may amplify potential for future The occurrence of infections multidrug-resistant (MDR), extensively drug-resistant (XDR), difficult-to-treat (DTR), carbapenem-resistant (CR), pan-drug-resistant (PDR) bacteria still increasing. aim review highlight state art worldwide, focusing on most important pathogens, namely Enterobacterales, Acinetobacter baumannii, Klebsiella pneumoniae, their common antibiotics.

Язык: Английский

Процитировано

28
The Hidden Cost of COVID-19: Focus on Antimicrobial Resistance in Bloodstream Infections DOI Creative Commons
Giulia Micheli,

Flavio Sangiorgi,

Francesca Catania

и другие.

Microorganisms, Год журнала: 2023, Номер 11(5), С. 1299 - 1299

Опубликована: Май 16, 2023

Antibiotic resistance is one of the greatest growing public health threats and a worldwide priority. According to WHO, drug-resistant diseases may cause 10 million deaths year by 2050 have substantial impact on global economy, driving up 24 people into poverty. The ongoing COVID-19 pandemic has exposed fallacies vulnerability healthcare systems worldwide, displacing resources from existing programs reducing funding for antimicrobial (AMR) fighting efforts. Moreover, as already seen other respiratory viruses, such flu, often associated with superinfections, prolonged hospital stays, increased ICU admissions, further aggravating disruption. These events are accompanied widespread antibiotic use, misuse, inappropriate compliance standard procedures potential long-term AMR. Still, COVID-19-related measures increasing personal environmental hygiene, social distancing, decreasing admissions could theoretically help AMR cause. However, several reports shown during pandemic. This narrative review focuses this “twindemic”, assessing current knowledge in era focus bloodstream infections provides insights lessons learned field that be applied stewardship initiatives.

Язык: Английский

Процитировано

25
Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event DOI Creative Commons
Karyne Rangel, Salvatore G. De-Simone

Infection and Drug Resistance, Год журнала: 2024, Номер Volume 17, С. 507 - 529

Опубликована: Фев. 1, 2024

Abstract: Acinetobacter pneumonia is a significant healthcare-associated infection that poses considerable challenge to clinicians due its multidrug-resistant nature. Recent world events, such as the COVID-19 pandemic, have highlighted need for effective treatment and management strategies pneumonia. In this review, we discuss lessons learned from recent particularly in context of We performed an extensive literature review uncover studies information pertinent topic. The pandemic underscored importance control measures healthcare settings, including proper hand hygiene, isolation protocols, personal protective equipment use, prevent spread pathogens like . Additionally, crucial role antimicrobial stewardship programs optimizing antibiotic use curbing emergence resistance. Advances diagnostic techniques, rapid molecular testing, also proven valuable identifying infections promptly. Furthermore, limited availability antibiotics treating caused A. baumannii , alternative are needed peptides, bacteriophages their enzymes, nanoparticles, photodynamic chelate therapy. provided insights into These emphasize significance control, stewardship, early diagnostics combating challenging infection. Keywords: ventilator-associated pneumonia, VAP, hospital-acquired HAP, carbapenem-resistant CRAB,

Язык: Английский

Процитировано

10
Interventions for Improving Long COVID-19 Symptomatology: A Systematic Review DOI Creative Commons
Nicola Veronese,

Roberta Bonica,

Sergio Cotugno

и другие.

Viruses, Год журнала: 2022, Номер 14(9), С. 1863 - 1863

Опубликована: Авг. 24, 2022

Although the understanding of several aspects long COVID-19 syndrome is increasing, there limited literature regarding treatment these signs and symptoms. The aim our systematic review was to understand which therapies have proved effective against symptoms COVID-19.

Язык: Английский

Процитировано

38
Azithromycin through the Lens of the COVID-19 Treatment DOI Creative Commons
Georgia G. Kournoutou, George P. Dinos

Antibiotics, Год журнала: 2022, Номер 11(8), С. 1063 - 1063

Опубликована: Авг. 5, 2022

Azithromycin has become famous in the last two years, not for its main antimicrobial effect, but potential use as a therapeutic agent COVID-19 infection. Initially, there were some promising results that supported use, it clear scientific are insufficient to support such positive assessment. In this review we will present all literature data concerning activity of azithromycin an antimicrobial, anti-inflammatory, or antivirus agent. Our aim is conclude whether selection should remain valuable if simply indirect contribution due and/or immunomodulatory activity, and therefore, further treatment be interrupted. This halt prevent antibiotic resistance expansion keep anti-infective

Язык: Английский

Процитировано

35
Acinetobacter baumannii Isolates from COVID-19 Patients in a Hospital Intensive Care Unit: Molecular Typing and Risk Factors DOI Creative Commons
Mariateresa Ceparano, Valentina Baccolini, Giuseppe Migliara

и другие.

Microorganisms, Год журнала: 2022, Номер 10(4), С. 722 - 722

Опубликована: Март 28, 2022

Infections caused by Acinetobacter baumannii represent a major concern for intensive care unit (ICU) patients. However, the epidemiology of these infections among COVID-19 patients has not been fully explored. The aims this study were (i) to characterize clonal spread A. admitted ICU Umberto I hospital Rome during first year pandemic and (ii) identify risk factors its acquisition. Isolates analysed pulsed-field gel electrophoresis, multivariable regression model was constructed. Adjusted odds ratios (aORs) 95% confidence intervals (CIs) calculated. Overall, 193 included, 102 strains analysed. All isolates had highly antibiotic-resistant profiles derived from two genotypes. cumulative incidence acquisition (colonization or infection) 36.8%. Patients with higher mortality length stay. Multivariable analysis showed that previous carbapenem use only factor associated (aOR: 4.15, CI: 1.78-9.64). We documented substantial colonization high levels transmission. Given limited treatment options, effective prevention containment strategies limit should be implemented.

Язык: Английский

Процитировано

32