Archives of Microbiology, Journal Year: 2022, Volume and Issue: 204(8)
Published: July 30, 2022
Language: Английский
European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 255, P. 115377 - 115377
Published: April 20, 2023
Language: Английский
Citations
112
Antibiotics, Journal Year: 2022, Volume and Issue: 11(3), P. 349 - 349
Published: March 6, 2022
Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, brings public health issues causes economic burden. Pathogenic bacteria develop several methods to resist antibiotic killing or inhibition, mutation function sites, activation drug efflux pumps, enzyme-mediated degradation. Antibiotic resistance components can be transferred between by mobile genetic elements including plasmids, transposons, integrons, well bacteriophages. The development limits the treatment options for bacterial infection, especially MDR bacteria. Therefore, novel alternative antibacterial agents are urgently needed. Antimicrobial peptides (AMPs) display multiple mechanisms against infections, directly bactericidal activity immunomodulatory function, potential alternatives antibiotics. In this review, resistance, AMPs, especially, design, optimization, delivery AMPs reviewed. Strategies structural change, amino acid substitution, conjugation with cell-penetration peptide, terminal acetylation amidation, encapsulation nanoparticles will improve antimicrobial efficacy, reduce toxicity, accomplish local AMPs. addition, clinical trials in AMP studies applications within last five years were summarized. Overall, diverse action infection pathogenic future research investigations accelerate application.
Language: Английский
Citations
87
Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 771 - 771
Published: June 4, 2022
The objectives of this study were to investigate the incidence candidemia, as well factors associated with Candida species distribution and fluconazole resistance, among patients admitted intensive care unit (ICU) during COVID-19 pandemic, compared two pre-pandemic periods. All ICU due from March 2020 October 2021, periods (2005-2008 2012-2015), who developed included. During period, candidemia was 10.2%, significantly higher 3.2% 4.2% in periods, respectively. proportion non-albicans increased (from 60.6% 62.3% 75.8%, respectively), a predominance C. parapsilosis. A marked increase resistance 31% 37.7% 48.4%, respectively) also observed. Regarding total patient population (n = 205), independently length stay (LOS) before (OR 1.03; CI: 1.01-1.06, p 0.003), whereas presence shock at onset albicans 6.89; 2.2-25, 0.001), fluconazole-susceptible 0.23; 0.07-0.64, 0.006). In conclusion, substantial increases non-albicansCandida species, found COVID-19, At onset, prolonged LOS fluconazole-resistant species.
Language: Английский
Citations
48
Antibiotics, Journal Year: 2022, Volume and Issue: 11(3), P. 315 - 315
Published: Feb. 25, 2022
The outbreak of COVID-19 has significantly changed the epidemiology respiratory tract infection in several ways. implementation non-pharmaceutical interventions (NPIs) including universal masking, hand hygiene, and social distancing not only resulted a decline reported SARS-CoV-2 cases but also contributed to non-COVID-19 infection-related hospital utilization. Moreover, it led decreased incidence previous commonly encountered pathogens, such as influenza Streptococcus pneumoniae. Although antimicrobial agents are essential for treating patients with co-infection, prescribing antibiotics was higher than estimated prevalence bacterial which indicated overuse or unnecessary antibiotic use during pandemic. Furthermore, inappropriate exposure may drive selection drug-resistant microorganisms, disruption control setting measures result spread multidrug-resistant organisms (MDROs). In conclusion, NPIs could be effective preventing changing microbiologic distribution pathogens; however, we should continue epidemiological surveillance establish updated information, stewardship programs appropriate antibiotic, prevention prevent MDROs
Language: Английский
Citations
42
Viruses, Journal Year: 2023, Volume and Issue: 15(9), P. 1843 - 1843
Published: Aug. 30, 2023
Antibacterial resistance is a renewed public health plague in modern times, and the COVID-19 pandemic has rekindled this problem. Changes antibiotic prescribing behavior, misinformation, financial hardship, environmental impact, governance gaps have generally enhanced misuse improper access to antibiotics during pandemic. These determinants, intersected with antibacterial current pandemic, may amplify potential for future The occurrence of infections multidrug-resistant (MDR), extensively drug-resistant (XDR), difficult-to-treat (DTR), carbapenem-resistant (CR), pan-drug-resistant (PDR) bacteria still increasing. aim review highlight state art worldwide, focusing on most important pathogens, namely Enterobacterales, Acinetobacter baumannii, Klebsiella pneumoniae, their common antibiotics.
Language: Английский
Citations
27
Infection, Journal Year: 2023, Volume and Issue: 51(4), P. 1061 - 1069
Published: March 3, 2023
Abstract Purpose SARS-COV-2 pandemic led to antibiotic overprescription and unprecedented stress on healthcare systems worldwide. Knowing the comparative incident risk of bloodstream infection due multidrug-resistant pathogens in COVID ordinary wards intensive care-units may give insights into impact COVID-19 antimicrobial resistance. Methods Single-center observational data extracted from a computerized dataset were used identify all patients who underwent blood cultures January 1, 2018 May 15, 2021. Pathogen-specific incidence rates compared according time admission, patient’s status ward type. Results Among 14,884 for whom at least one culture was obtained, total 2534 diagnosed with HA-BSI. Compared both pre-pandemic COVID-negative wards, HA-BSI S. aureus Acinetobacter spp . (respectively 0.3 [95% CI 0.21–0.32] 0.11 [0.08–0.16] new infections per 100 patient-days) showed significantly higher rates, peaking COVID-ICU setting. Conversely, E. coli 48% lower COVID-positive vs settings (IRR 0.53 [0.34–0.77]). + patients, ( n = 38/79) isolates resistant methicillin 40% 10/25) K. pneumoniae carbapenems. Conclusions The presented here indicate that spectrum causing BSI care units varied during pandemic, greatest shift experienced by COVID-ICUs. Antimicrobial resistance selected high-priority bacteria high positive settings.
Language: Английский
Citations
23
Microorganisms, Journal Year: 2023, Volume and Issue: 11(5), P. 1299 - 1299
Published: May 16, 2023
Antibiotic resistance is one of the greatest growing public health threats and a worldwide priority. According to WHO, drug-resistant diseases may cause 10 million deaths year by 2050 have substantial impact on global economy, driving up 24 people into poverty. The ongoing COVID-19 pandemic has exposed fallacies vulnerability healthcare systems worldwide, displacing resources from existing programs reducing funding for antimicrobial (AMR) fighting efforts. Moreover, as already seen other respiratory viruses, such flu, often associated with superinfections, prolonged hospital stays, increased ICU admissions, further aggravating disruption. These events are accompanied widespread antibiotic use, misuse, inappropriate compliance standard procedures potential long-term AMR. Still, COVID-19-related measures increasing personal environmental hygiene, social distancing, decreasing admissions could theoretically help AMR cause. However, several reports shown during pandemic. This narrative review focuses this “twindemic”, assessing current knowledge in era focus bloodstream infections provides insights lessons learned field that be applied stewardship initiatives.
Language: Английский
Citations
23
Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 507 - 529
Published: Feb. 1, 2024
Abstract: Acinetobacter pneumonia is a significant healthcare-associated infection that poses considerable challenge to clinicians due its multidrug-resistant nature. Recent world events, such as the COVID-19 pandemic, have highlighted need for effective treatment and management strategies pneumonia. In this review, we discuss lessons learned from recent particularly in context of We performed an extensive literature review uncover studies information pertinent topic. The pandemic underscored importance control measures healthcare settings, including proper hand hygiene, isolation protocols, personal protective equipment use, prevent spread pathogens like . Additionally, crucial role antimicrobial stewardship programs optimizing antibiotic use curbing emergence resistance. Advances diagnostic techniques, rapid molecular testing, also proven valuable identifying infections promptly. Furthermore, limited availability antibiotics treating caused A. baumannii , alternative are needed peptides, bacteriophages their enzymes, nanoparticles, photodynamic chelate therapy. provided insights into These emphasize significance control, stewardship, early diagnostics combating challenging infection. Keywords: ventilator-associated pneumonia, VAP, hospital-acquired HAP, carbapenem-resistant CRAB,
Language: Английский
Citations
10
Viruses, Journal Year: 2022, Volume and Issue: 14(9), P. 1863 - 1863
Published: Aug. 24, 2022
Although the understanding of several aspects long COVID-19 syndrome is increasing, there limited literature regarding treatment these signs and symptoms. The aim our systematic review was to understand which therapies have proved effective against symptoms COVID-19.
Language: Английский
Citations
38
Antibiotics, Journal Year: 2022, Volume and Issue: 11(8), P. 1063 - 1063
Published: Aug. 5, 2022
Azithromycin has become famous in the last two years, not for its main antimicrobial effect, but potential use as a therapeutic agent COVID-19 infection. Initially, there were some promising results that supported use, it clear scientific are insufficient to support such positive assessment. In this review we will present all literature data concerning activity of azithromycin an antimicrobial, anti-inflammatory, or antivirus agent. Our aim is conclude whether selection should remain valuable if simply indirect contribution due and/or immunomodulatory activity, and therefore, further treatment be interrupted. This halt prevent antibiotic resistance expansion keep anti-infective
Language: Английский
Citations
35