Molecules,
Год журнала:
2025,
Номер
30(11), С. 2443 - 2443
Опубликована: Июнь 3, 2025
Andrographolide,
fucoidan,
or
a
combination
of
both
compounds
were
evaluated
to
determine
their
effects
on
the
antiviral
response
in
Atlantic
salmon
macrophage-like
cell
line
(SHK-1)
infected
with
infectious
pancreatic
necrosis
virus
(IPNV).
We
assessed
transcript
expression
levels
key
molecules
involved
interferon
(IFN)-dependent
response,
as
well
viral
load
cells
treated
these
compounds.
In
non-infected
cells,
incubation
either
andrographolide,
mixture
resulted
an
increase
IFNα1
and
various
interferon-stimulated
genes
(ISGs).
IPNV-infected
treatment
fucoidan
andrographolide
separately
did
not
significantly
enhance
compared
that
had
previously
been
contrast,
led
marked
viperin
significant
reduction
load.
Overall,
combining
greater
IPNV
than
noted
when
administered
individually.
Our
findings
suggest
pre-incubation
this
promotes
establishment
protective
state
against
IPNV,
likely
mediated
by
IFN-dependent
response.
Journal of Genetic Engineering and Biotechnology,
Год журнала:
2024,
Номер
22(4), С. 100407 - 100407
Опубликована: Авг. 24, 2024
For
use
in
specialized
programs
the
food,
pharmaceutical,
nutraceutical,
cosmetic,
and
animal
feed
sectors,
micro-algal
biomass
has
been
generated
industrially.
They
can
be
grown
closed
buildings,
such
as
photobioreactors,
or
open
structures.
The
utilization
of
from
microalgae
for
energy
production
is
another
crucial
topic.
Because
world's
diminishing
petroleum
sources
greenhouse
gas
emissions
gasoline
lines,
it
now
obvious
that
fuels
are
not
sustainable.
Biomacromolecules,
Год журнала:
2024,
Номер
26(1), С. 341 - 362
Опубликована: Дек. 25, 2024
Acyclovir
(ACV)
is
a
potentially
effective
antiviral
medication;
however,
it
has
serious
drawback,
which
its
poor
solubility,
bioavailability,
and
short
half-life.
The
goal
of
this
study
to
improve
drawbacks
through
the
synthesis
nanogels.
In
study,
cross-linked
hyaluronic
acid-grafted
poly(acrylamide-co-itaconic
acid)
nanogel
synthesized
successfully
free
radical
polymerization
used
as
safe
pH-responsive
carrier
for
ACV.
nanogels
showed
pH
response
in
vitro
vivo.
prepared
C5
(1:1
ratio
acrylamide:
itaconic),
had
highest
grafting
efficiency,
maximum
swelling,
drug
loading,
release
7.4,
higher
than
1.2.
Also,
C5,
large
surface
area,
good
stability,
matrices
shrank
acidic
medium
protected
drug,
while
basic
medium,
expanded
released
ACV
sustained
manner
improved
bioavailability
half-life
Applied Sciences,
Год журнала:
2024,
Номер
14(11), С. 4610 - 4610
Опубликована: Май 27, 2024
Cordyceps
militaris
is
a
valuable
medicinal
fungus
which
has
been
widely
used
as
traditional
medicine
in
East
Asia.
Compared
to
the
well-known
C.
sinensis,
can
produce
similar
fermented
metabolites
with
various
biological
activities,
but
it
requires
shorter
culture
time
and
simpler
conditions,
therefore,
attracted
increasing
attention
recent
years.
The
purpose
of
this
review
was
organize
current
studies
regarding
metabolite
production
from
relative
their
functions.
We
combined
findings
correlate
different
fermentation
modes
obtain
full
view
processes
yield
product.
While
research
on
not
uncommon
date,
its
high
value
still
highlights
importance
developing
more
modern
for
industrial
production.
Macromolecular Chemistry and Physics,
Год журнала:
2024,
Номер
225(17)
Опубликована: Май 28, 2024
Abstract
This
review
article
explores
the
recent
innovations
in
field
of
antimicrobial
and
antiviral
macromolecules.
With
rising
challenge
antibiotic
resistance,
as
well
overuse
antibiotics,
there
is
a
growing
demand
for
efficient
solutions
to
combat
microbial
viral
infections.
The
development
new
effective
agents
highlighted.
designed
give
comprehensive
view
literature
focusing
on
few
examples
combating
infections
each
section.
A
brief
description
naturally
occurring
organic‐based
materials
that
exhibit
and/or
activities
presented,
polysaccharides,
peptides,
proteins.
Synthetic
are
divided
into
subsections
including
polymers,
dendrimers,
nanomaterials.
synthesis
applications
inorganic
such
polyphosphazenes
polysiloxanes,
tin‐,
germanium‐
gallium‐based
emphasized
this
review.
Organometallic
macromolecules
also
described,
their
examined.
Overall,
provides
overview
advancements
design
macromolecules,
offering
valuable
insights
potential
biomedical
research
drug‐resistant
microorganisms
viruses.
Traditional
medicine
systems
worldwide
utilize
natural
products
(NPs),
including
plant-derived
compounds,
minerals,
and
organisms,
harnessing
their
healing
potential.
NPs
offer
a
rich
source
of
potential
drug
candidates,
driving
innovation
in
discovery.
Recent
breakthroughs
have
reignited
interest
the
therapeutic
benefits
compounds.
Clinical
applications
NP-based
immunotherapies,
such
as
curcumin
resveratrol
cancer
treatment,
highlight
diverse
pharmacological
properties.
However,
despite
these
advancements,
challenges
persist
clinical
implementation
NPs.
Issues
standardization,
regulatory
approval,
supply
sustainability
remain
significant
hurdles.
Overcoming
limitations
requires
concerted
effort
to
address
complexities
NP
development.
Nevertheless,
ongoing
research
efforts
interdisciplinary
collaboration
hold
promise
for
advancing
therapeutics,
paving
way
development
innovative
treatments
various
diseases.
In
world
precision
medicine,
new
chapter
unfolds
join
journey.
The
exploration
sources
bioactive
compounds
has
revealed
promising
prospects
therapeutics
medicine.
This
article
explores
within
context
It
examines
intricate
pathways
through
which
derived
from
nature
tailored
prospects,
emphasizing
role
interventions.
Exploring
synergy
between
at
molecular
level,
this
delineates
exciting
prospect
customized
treatments,
signifying
transformative
impact
on
modern
medical
care.
review
further
highlights
tailoring
based
individual
genetic
makeup
disease
characteristics.
Additionally,
it
discusses
addressing
issues
sourcing,
scalability,
considerations
realize
full
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 1068 - 1068
Опубликована: Март 19, 2025
The
issue
of
antibiotic-resistant
bacterial
infections,
coupled
with
the
rise
in
viral
pandemics
and
slow
development
new
antibacterial
antiviral
treatments,
underscores
critical
need
for
novel
strategies
to
mitigate
spread
drug-resistant
pathogens,
enhance
efficacy
existing
therapies,
accelerate
discovery
deployment
innovative
antimicrobial
solutions.
One
promising
approach
address
these
challenges
is
dietary
supplementation
non-digestible
oligosaccharides
(NDOs).
NDOs,
including
human
milk
(HMOs),
play
a
vital
role
shaping
sustaining
healthy
gut
microbiota.
Beyond
stimulating
growth
activity
beneficial
bacteria,
NDOs
can
also
interact
directly
pathogenic
bacteria
viruses.
Their
properties
arise
from
their
unique
interactions
pathogens
ability
modulate
host’s
immune
system.
function
as
decoy
receptors,
inhibit
pathogen
growth,
bind
toxins,
stimulate
host
response,
exhibit
anti-biofilm
properties,
barrier
protection.
However,
notable
gap
exists
comprehensive
assessment
vivo
clinical
data
on
this
topic.
This
review
aims
provide
an
in-depth
overview
evidence
related
effects
various
HMOs,
focus
discussing
possible
mechanisms
action.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(4), С. 502 - 502
Опубликована: Март 31, 2025
Background/Objectives:
Polysaccharides
are
complex
molecules
with
a
wide
range
of
biological
activities
that
can
be
used
in
various
biomedical
applications.
In
this
work,
the
antiulcer
effect
and
influence
on
level
pro-
anti-inflammatory
cytokines
Solanum
tuberosum
L.
polysaccharide
(STP)
were
studied.
Methods:
The
STP
was
studied
Okabe
chronic
peptic
ulcer
model
by
evaluating
index
Wistar
rats,
comparing
it
to
omeprazole
ranitidine.
Dose-effect
analysis
also
carried
out.
using
ELISA
kits.
Results:
After
treatment
groups,
healing
is
observed
60–80%
cases,
group
50%,
ranitidine
25%.
intravenous
injections
lead
formation
more
differentiated
mucous
membrane;
no
coarse
scar
tissue
formed,
which
typical
for
control
comparison
drugs.
Glycan
causes
significant
acceleration
experimental
ulcers
rats.
appears
modulate
cytokines.
On
fourth
tenth
days,
decrease
levels
pro-inflammatory
IL-1b
IFN-γ
noted
compared
group,
while
cytokine
IL-4
significantly
increased.
Conclusions:
Intravenous
administration
leads
restoration
functionality
effective
regeneration.
activity
based
regulation
balance.
