Estimation of trajectory of COVID-19 vaccines effectiveness against infection

Vaccine, Год журнала: 2025, Номер 55, С. 127067 - 127067

Опубликована: Март 31, 2025

Язык: Английский

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The Change in Demographic and Clinical Features of Hospitalized Omicron Patients After the Pandemic: A Territory-wide Retrospective Cohort Study (Preprint)

Опубликована: Апрель 8, 2025

The Omicron variant of SARS-CoV-2 underwent several mutations since it was first identified in November 2021, with a large case outbreak Hong Kong during early 2022. Yet, local cases infections persist, even though COVID-19 ended May 2023. Therefore, this study aims to compare the changes clinical and demographic characteristics hospitalized patients Kong. primary objective compared different strains, while secondary post-pandemic. This cohort collected data on infected admitted public hospitals between 1st 2022 31st 2024. Later categorized into 3 periods based strain. Subsequent descriptive analysis conducted each characteristic identify any significant differences (primary objective) within (secondary periods. 136,544 episodes were 72,471 that occurred period 1, 41,167 2, 22,906 3. Notably, case-fatality ratio increased from 6.3 6.4. Demographic significantly for age (0-17 years old, 18-64 ≥85 old: Adjusted P<.001), sex (Adjusted Charlson Comorbidity Index score (0: P=.04, 1: P=.003), comorbidities (type 2 diabetes mellitus: race (Pakistani: length hospital stay social deprivation index (Most disadvantaged: P<.001) Clinical also levels blood biomarkers (Albumin, Neutrophil, Lymphocyte, Platelet: in-patient drug administration (ACE inhibitors, antidiabetics, antiplatelets anticoagulants, beta blockers, bronchodilators, calcium channel diuretics, inhaled corticosteroids, rheumatoid drugs, statins, systemic corticosteroids: P<.001). Post-hoc results comparing within-groups showed spill-over post-pandemic era adults P=.91), type mellitus P=1.00), Pakistani P=.61), 0 CCI P=.18). Despite decreasing incidence Kong, increasing suggests long-term surveillance should be maintained prepare potential outbreaks.

Язык: Английский

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Comparison of safety and efficacy between Nirmatrelvir-ritonavir and molnupiravir in the treatment of COVID-19 infection in patients with advanced kidney disease: a retrospective observational study

EClinicalMedicine, Год журнала: 2024, Номер 72, С. 102620 - 102620

Опубликована: Май 3, 2024

Язык: Английский

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Prevalence and correlators of burnout among health professionals during different stages of the COVID-19 pandemic in China

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Апрель 26, 2023

Persistently increased workload and stress occurred in health professionals (HPs) during the past 3 years as COVID-19 pandemic continued. The current study seeks to explore prevalence of correlators HPs' burnout different stages pandemic.

Язык: Английский

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Epidemiology of multidrug-resistant organisms before and during COVID-19 in Hong Kong

Infection Prevention in Practice, Год журнала: 2023, Номер 5(2), С. 100286 - 100286

Опубликована: Май 8, 2023

The coronavirus disease 2019 (COVID-19) has influenced antimicrobial consumption and incidence of multidrug-resistant organisms (MDROs). We aimed to study the epidemiology MDROs before during COVID-19 pandemic in Hong Kong.With maintenance infection control measures, we described trend MDRO infections, including methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Acinetobacter species (CRA), extended-spectrum-beta-lactamase-(ESBL)-producing Enterobacterales, a healthcare region with 3100-bed (1 January 2016 31 December 2019, period 1) 2020 30 September 2022, 2), together using piecewise Poisson regression. epidemiological characteristics newly diagnosed patients or without infections were analyzed.Between 1 2, observed significant increase CRA (P<0.001), while there was no MRSA (P=0.742) ESBL-producing Enterobacterales (P=0.061) infections. Meanwhile, carbapenems extended-spectrum beta-lactam-beta-lactamase inhibitor combinations (BLBI) (P=0.045), fluoroquinolones (P=0.009) observed. opportunity (23,540 ± 3703 vs 26,145 2838, p=0.359) compliance (81.6% 0.5% 80.1% 0.8%, P=0.209) hand hygiene per year maintained. In multivariable model, older age, male sex, referral from residential care home for elderly, presence indwelling device, endotracheal tube, use carbapenems, BLBI, proton pump inhibitors history hospitalization past 3 months associated higher risks by among patients.Infection measures may surge despite an increasing consumption.

Язык: Английский

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Comparative analysis of symptom profile and risk of death associated with infection by SARS‐CoV‐2 and its variants in Hong Kong

Journal of Medical Virology, Год журнала: 2024, Номер 96(2)

Опубликована: Фев. 1, 2024

Abstract The recurrent multiwave nature of coronavirus disease 2019 (COVID‐19) necessitates updating its symptomatology. We characterize the effect variants on symptom presentation, identify symptoms predictive and protective death, quantify vaccination development. With COVID‐19 cases reported up to August 25, 2022 in Hong Kong, an iterative multitier text‐matching algorithm was developed from free text. Multivariate regression used measure associations between variants, development, status. A least absolute shrinkage selection operator technique a parsimonious set jointly associated with death. Overall, 70.9% (54 450/76 762) were symptomatic 102 identified. Intrinsically, wild‐type delta variant caused similar among unvaccinated cases, whereas omicron BA.2 subvariant had heterogeneous patterns, seven (fatigue, fever, chest pain, runny nose, sputum production, nausea/vomiting, sore throat) more frequent cohort. ≥2 vaccine doses, likely than cause fever cases. Fever, blocked pneumonia, shortness breath remained death elderly wild‐type‐to‐omicron transition. Number doses required for reducing occurrence varied by symptoms. substantiate that has different clinical presentation compared previous variants. Syndromic surveillance can be bettered reduced reliance symptom‐based case identification, increased weighing outcome prediction, individual‐based risk assessment care homes, incorporating free‐text reporting.

Язык: Английский

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Transmission Patterns of Co-Circulation of Omicron Sub-Lineages in Hong Kong SAR, China, a City with Rigorous Social Distancing Measures, in 2022

Viruses, Год журнала: 2024, Номер 16(6), С. 981 - 981

Опубликована: Июнь 18, 2024

Objective: This study aimed to characterize the changing landscape of circulating SARS-CoV-2 lineages in local community Hong Kong throughout 2022. We examined how adjustments quarantine arrangements influenced transmission pattern Omicron variants a city with relatively rigorous social distancing measures at that time. Methods: In 2022, total 4684 genomes were sequenced using Oxford Nanopore GridION sequencer. consensus generated by MAFFT, and maximum likelihood phylogeny these was determined IQ-TREE. The dynamic changes depicted time tree created Nextstrain. Statistical analysis conducted assess correlation between number arrangements. Results: By end 83 identified community. increase new significantly associated relaxation (One-way ANOVA, F(5, 47) = 18.233, p < 0.001)). Over time, BA.5 sub-lineages replaced BA.2.2 became predominant Kong. influx reshaped dynamics without fluctuating death rate hospitalization 2.037, 0.091). Conclusion: revealed even an extended mandatory period for incoming travelers, it may not be feasible completely prevent introduction subsequent spread highly contagious variants. Ongoing molecular surveillance COVID-19 remains essential monitor emergence recombinant

Язык: Английский

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Changes in the incidence, clinical features and outcomes of tuberculosis during COVID-19 pandemic

Journal of Infection and Public Health, Год журнала: 2024, Номер 17(9), С. 102511 - 102511

Опубликована: Июль 26, 2024

COVID-19 pandemic has disrupted tuberculosis (TB) services in many countries, but the impacts on sites of involvement, drug susceptibility, smear positivity and clinical outcomes, outcomes co-infection with influenza remain unclear.

Язык: Английский

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Assessing the Impact of Primary-Series Infection and Booster Vaccination on Protection against Omicron in Hong Kong: A Population-Based Observational Study

Vaccines, Год журнала: 2024, Номер 12(9), С. 1014 - 1014

Опубликована: Сен. 5, 2024

This study aimed to assess the real-world effectiveness of vaccines and hybrid immunity in preventing infections during Omicron prevalent period Hong Kong. analyzed vaccination records COVID-19 confirmed case from 1 January 2022 28 2023 included a total 7,165,862 individuals with or infection records. found that an additional vaccine dose offered increased protection against BA.1/2 BA.4 for without prior general. Hybrid immunity, acquired through natural infection, was be significantly stronger than provided by alone. The Comirnaty Original/Omicron BA.4/5 bivalent vaccine, introduced December 2022, associated lower risk when administered as booster after three doses CoronaVac. However, four CoronaVac did not exhibit compared those dominant period. highlights importance promoting shot uptake encouraging among who have recovered infections. potential immune imprinting effect underscores need continued surveillance research optimize strategies emerging variants.

Язык: Английский

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Generational differences in health information behaviors during the COVID-19 crisis: A Hong Kong study

Global Media and China, Год журнала: 2024, Номер 9(3), С. 303 - 324

Опубликована: Март 13, 2024

The literature has explored age differences in health information seeking during the COVID-19 pandemic. However, there is a noticeable gap research regarding generational variations underlying factors of scanning and sharing, as well interplay seeking, scanning, sharing. This study examined: (1) risk- channel-related motivators online sharing among three cohorts: Baby Boomers, Generation X, Millennials; (2) relationship between focus on took into consideration both biological social cohorts when comparing their behaviors. data came from an survey 1,004 Hong Kong residents. Results showed similarities individuals’ more frequent than positive Generational emerged several aspects, including frequency scanning; status seeking; associations income, status, channel characteristics, utility with These findings offer insights how may differ generations or transcend shaping behaviors historical cultural context Kong. our inform communication strategies for different groups future public crises.

Язык: Английский

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