SARS-CoV-2 Vaccines: The Advantage of Mucosal Vaccine Delivery and Local Immunity DOI Creative Commons
Joshua Tobias, Peter Steinberger,

Joy Wilkinson

и другие.

Vaccines, Год журнала: 2024, Номер 12(7), С. 795 - 795

Опубликована: Июль 18, 2024

Immunity against respiratory pathogens is often short-term, and, consequently, there an unmet need for the effective prevention of such infections. One infectious disease coronavirus 19 (COVID-19), which caused by novel Beta SARS-CoV-2 that emerged around end 2019. The World Health Organization declared illness a pandemic on 11 March 2020, and since then it has killed or sickened millions people globally. development COVID-19 systemic vaccines, impressively led to significant reduction in severity, hospitalization, mortality, contained pandemic’s expansion. However, these vaccines have not been able stop virus from spreading because restricted mucosal immunity. As result, breakthrough infections frequently occurred, new strains emerging. Furthermore, will likely continue circulate like influenza virus, co-exist with humans. upper tract nasal cavity are primary sites infection thus, mucosal/nasal vaccination induce response virus’ transmission warranted. In this review, we present status both approved those under evaluation clinical trials. our approach B-cell peptide-based applied prime-boost schedule elicit

Язык: Английский

A systematic review and meta-analysis on the effectiveness of bivalent mRNA booster vaccines against Omicron variants DOI
Shangchen Song, Zachary J. Madewell,

Ming‐Jin Liu

и другие.

Vaccine, Год журнала: 2024, Номер 42(15), С. 3389 - 3396

Опубликована: Апрель 22, 2024

Язык: Английский

Процитировано

8
Covid-19 infection and vaccination during first trimester and risk of congenital anomalies: Nordic registry based study DOI
Maria C. Magnus,

Jonas Söderling,

Anne K. Örtqvist

и другие.

BMJ, Год журнала: 2024, Номер unknown, С. e079364 - e079364

Опубликована: Июль 17, 2024

To evaluate the risk of major congenital anomalies according to infection with or vaccination against covid-19 during first trimester pregnancy. Prospective Nordic registry based study. Sweden, Denmark, and Norway. 343 066 liveborn singleton infants in Norway, an estimated start pregnancy between 1 March 2020 14 February 2022, identified using national health registries. Major were categorised EUROCAT (European Surveillance Congenital Anomalies) definitions. The after was assessed by logistic regression, adjusting for maternal age, parity, education, income, country origin, smoking, body mass index, chronic conditions, date 17 704 (5.2%) had a anomaly. When evaluating associated trimester, adjusted odds ratio ranged from 0.84 (95% confidence interval 0.51 1.40) eye 1.12 (0.68 1.84) oro-facial clefts. Similarly, (0.31 2.31) nervous system 1.69 (0.76 3.78) abdominal wall defects. Estimates 10 11 subgroups less than 1.04, indicating no notable increased risk. Covid-19 not anomalies.

Язык: Английский

Процитировано

8
The omicron variant of SARS-CoV-2 drove broadly increased seroprevalence in a public university setting DOI Creative Commons
Ching‐Wen Hou,

Stacy Williams,

Guillermo Trivino-Soto

и другие.

PLOS Global Public Health, Год журнала: 2025, Номер 5(1), С. e0003893 - e0003893

Опубликована: Янв. 3, 2025

Omicron is the comparatively most transmissible and contagious variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). We conducted a seroprevalence study from March 1–3, 2022, to investigate SARS-CoV-2 antibodies among individuals aged 18 years older after outbreak. The anti-receptor binding domain (RBD) was found be 96.3% (95% CI 95.2–97.2%) compared 88.2% 86.1–90%) in our previous serosurvey. For anti-nucleocapsid (NC) antibodies, 39.1% 36.6–41.7%) 19.7% 17.5–22.2%) earlier. Individuals that experienced breakthrough infections exhibited highest levels anti-RBD antibodies. Additionally, saliva samples showed promise as potential diagnostic biofluid for measuring antibody levels, they strong agreement with data obtained serum samples. near doubling anti-NC reactivity, proxy history infection, reflects contagiousness omicron variant, but may also have been influenced by more relaxed approach precautions spring 2022. Serosurveys repeated at regular intervals monitor trend community, delineate geographical spread guide containment measures communities, prompt response future outbreaks.

Язык: Английский

Процитировано

1
The Second Life for Unused COVID-19 Vaccines: Towards Biosensing Application DOI
Vincentas Mačiulis, Asta Lučiūnaitė,

Mantvydas Usvaltas

и другие.

Talanta, Год журнала: 2025, Номер unknown, С. 127647 - 127647

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Tracing Emergence of SARS-CoV-2 Variants: Insights from Comprehensive Assessment Using Reverse Transcription Polymerase Chain Reaction and Whole Genome Sequencing DOI Creative Commons

D. Na,

Yuna Hong, C. Lee

и другие.

Microorganisms, Год журнала: 2025, Номер 13(2), С. 311 - 311

Опубликована: Янв. 31, 2025

The emergence and evolution of SARS-CoV-2 variants, such as Delta Omicron, pose significant challenges to pandemic management. This study evaluated the effectiveness reverse-transcription polymerase chain reaction (RT-PCR) whole-genome sequencing (WGS) in detecting characterizing variants using 624 samples collected South Korea from mid-2021 mid-2022. Two RT-PCR genotyping assays demonstrated a high concordance rate (90.4%) identifying variant during its dominance. In contrast, WGS revealed extensive genetic diversity among Omicron sub-lineages, 29 distinct including two Korea-specific (BA.1.1.5 BA.2.3.8). Clustering analysis data highlighted groupings BA.1, BA.2, BA.5 with overlap shared mutations suggesting evolutionary convergence. Sub-lineage expanded rapid transmission phases subsequently consolidated dominant lineages emerged. These findings highlight complementary strengths underscore importance integrating these methodologies for effective monitoring public health response.

Язык: Английский

Процитировано

1
Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment DOI Creative Commons
Mark C. Chappell

Circulation Research, Год журнала: 2023, Номер 132(10), С. 1320 - 1337

Опубликована: Май 11, 2023

The current epidemic of corona virus disease (COVID-19) has resulted in an immense health burden that became the third leading cause death and potentially contributed to a decline life expectancy United States. severe acute respiratory syndrome-related coronavirus-2 binds surface-bound peptidase angiotensin-converting enzyme 2 (ACE2, EC 3.4.17.23) tissue infection viral replication. ACE2 is important enzymatic component renin-angiotensin system (RAS) expressed lung other organs. regulates levels peptide hormones Ang II Ang-(1–7), which have distinct opposing actions one another, as well cardiovascular peptides. A potential consequence reduced activity by internalization viral-ACE2 complex subsequent activation RAS (higher ratio II:Ang-[1–7]) may exacerbate inflammatory events COVID-19 patients possibly contribute effects long COVID-19. Moreover, present with array autoantibodies various components including II, ACE2, AT 1 Mas receptors. Greater severity also evident male patients, reflect underlying sex differences regulation functional arms RAS. review provides critical evaluation evidence for activated subjects whether this contributes greater males compared females.

Язык: Английский

Процитировано

18
Change in the Clinical Picture of Hospitalized Patients with COVID-19 between the Early and Late Period of Dominance of the Omicron SARS-CoV-2 Variant DOI Open Access
Robert Flisiak, Dorota Zarębska‐Michaluk, Krystyna Dobrowolska

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(17), С. 5572 - 5572

Опубликована: Авг. 26, 2023

This study aimed to compare the clinical picture of COVID-19 in initial and later period Omicron dominance identify populations still at risk. A retrospective comparison data 965 patients hospitalized during early Omicron's (EO, January-June 2022) with 897 from a (LO, July 2022-April 2023) SARSTer database was performed. Patients LO, compared EO, were older, had better condition on admission, lower need for oxygen mechanical ventilation, less frequent lung involvement imaging, showed much faster improvement. Moreover, overall mortality EO 14%, higher than that LO-9%. Despite milder course disease, exceeding 15% similar both groups among involvement. The accumulation risk factors such as an age 60+, comorbidities, involvement, saturation <90% resulted constant 98% patients, 8% 30% rate LO period. Multiple logistic regression revealed odds death phase. infections caused by currently dominant subvariants, prophylaxis is necessary people over 60 years age, especially those case pneumonia respiratory failure.

Язык: Английский

Процитировано

18
Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months DOI Creative Commons
Jennifer Serwanga, Violet Ankunda,

Jackson Sembera

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Март 16, 2023

Understanding how spike (S)-, nucleoprotein (N)-, and RBD-directed antibody responses evolved in mild asymptomatic COVID-19 Africa their interactions with SARS-CoV-2 might inform development of targeted treatments vaccines.

Язык: Английский

Процитировано

17
EG.5 (Eris) and BA.2.86 (Pirola) two new subvariants of SARS-CoV-2: a new face of old COVID-19 DOI

Abdolreza Esmaeilzadeh,

Fereshteh Ebrahimi, Armin Jahani Maleki

и другие.

Infection, Год журнала: 2024, Номер 52(2), С. 337 - 343

Опубликована: Янв. 3, 2024

Язык: Английский

Процитировано

7
Inhibitory Efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin-Converting Enzyme II DOI Open Access
Cheng‐Han Lin,

Ho-Ju Chang,

M. C. Lin

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2935 - 2935

Опубликована: Март 2, 2024

Blocking the interaction between SARS-CoV-2 spike protein and human angiotensin-converting enzyme II (hACE2) serves as a therapeutic strategy for treating COVID-19. Traditional Chinese medicine (TCM) treatments containing bioactive products could alleviate symptoms of severe However, emergence variants has complicated process developing broad-spectrum drugs. As such, aim this study was to explore efficacy TCM against through targeting viral with hACE2 receptor. Antiviral activity systematically evaluated using pseudovirus system. Scutellaria baicalensis (S. baicalensis) found be effective infection, it mediated protein. Moreover, active molecules S. were identified analyzed. Baicalein baicalin, flavone glycoside in baicalensis, respectively, exhibited strong inhibitory activities protein, respectively. Under optimized conditions, virus infection inhibited by 98% via baicalein-treated baicalin-treated hACE2. In summary, we potential inhibitors from that mediate Omicron Future studies on application baicalein baicalin are needed.

Язык: Английский

Процитировано

7