Опубликована: Окт. 10, 2023
O Lúpus Eritematoso
Nutrients, Год журнала: 2023, Номер 15(16), С. 3647 - 3647
Опубликована: Авг. 20, 2023
The first 1000 days after birth represent a critical window for gut microbiome development, which is essential immune system maturation and overall health. undergoes major changes during this period due to shifts in diet environment. Disruptions the microbiota early life can have lasting health effects, including increased risks of inflammatory disorders, autoimmune diseases, neurological obesity. Maternal environmental factors pregnancy infancy shape infant microbiota. In article, we will review how maintaining healthy important long-term Furthermore, briefly include fungal colonization its effects on host function, are discussed as part ecosystem. Additionally, describe potential approaches such hydrogels enriched with prebiotics probiotics, transplantation (GMT) pregnancy, age-specific microbial ecosystem therapeutics, CRISPR therapies targeting hold advancing research development. Nevertheless, thorough evaluation their safety, effectiveness, impacts crucial prior application clinical approach. article emphasizes need continued optimize development through targeted early-life interventions.
Язык: Английский
Процитировано
61
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Апрель 23, 2024
Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially pediatrics, celiac disease (also called gluten enteropathy), is gaining more and ground terms of diagnosis, also interest research. The data from the literature last decades attest chameleonic way its presentation, there may be both classic onset symptoms atypical symptoms. Given impact played by disease, optimal growth development children, current narrative review aims to highlight presentation methods, intended guide clinician towards inclusion pathology differential diagnosis scheme. To these we add summary general therapeutic lines regarding underlying condition existing comorbidities. In order place related information up date, performed a recent articles published international databases. We bring forward theories approaches manifestations. Among note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, disorders biological constants association with multiple autoimmunities. Knowing correlating them key management patients, thus reducing subsequent burden disease.
Язык: Английский
Процитировано
7
Antioxidants, Год журнала: 2025, Номер 14(3), С. 303 - 303
Опубликована: Март 1, 2025
Systemic lupus erythematosus (SLE) is an autoimmune disease that frequently diagnosed in female patients, caused by multiple interacting factors. It has a complex pathogenesis which can affect almost any organ, from the kidneys to cardiovascular, pulmonary, neurological, osteoarticular, and hematological systems. The present narrative review seeks elucidate role of reactive oxygen species (ROS) SLE. central question guiding this study what extent these serum protein modifications correlate with activity organ damage characterized decreased apoptosis increased necrosis T cells NETosis granulocytes. Given impact SLE diagnosis on one's life, aims evaluate intricacies oxidative stress its relevance treatment disease. Topics such as understanding processes stress, their damaging pathways, biomarkers, future assistance clinical decisions will be discussed article. accurate determination biomarkers taught improve both management disease, while antioxidant therapy may open new door for treatment.
Язык: Английский
Процитировано
1
Nutrients, Год журнала: 2023, Номер 15(11), С. 2535 - 2535
Опубликована: Май 29, 2023
Celiac disease (CD) and systemic lupus erythematosus (SLE) are two diseases intensively studied in all age groups, with an increasing incidence at the global level, possibly due to increased awareness of their accurate diagnosis as a consequence new research innovation technologies that have appeared medicine. The first is controllable condition found approximately 1% entire population form reaction environmental stimuli affecting individuals genetic susceptibility, causing gluten intolerance, gastrointestinal extradigestive symptoms, starting from subclinical stages culminating severe malabsorption. On other hand, autoimmune chameleon-like symptoms mainly female sex, which leaves its clinical mark on most organs, skin, eyes, kidneys cardiovascular, pulmonary, neurological, osteoarticular, hematological systems. Current studies focus correlation between celiac pathologies such thyroiditis (Hashimoto Graves–Basedow), type I diabetes, erythematosus. current review aims present summary data specialized literature regarding intercurrents by analyzing recent published PubMed.
Язык: Английский
Процитировано
15
Nutrients, Год журнала: 2023, Номер 15(15), С. 3359 - 3359
Опубликована: Июль 28, 2023
Numerous interrelationships are known in the literature that have final effect of unmasking or influencing various pathologies. Among these, present article aims to discuss connection between systemic lupus erythematosus (SLE) and human microbiome. The main purpose this work is popularize information about impact dysbiosis on pathogenesis evolutionary course pediatric patients with SLE. Added interest knowledge awareness adjunctive therapeutic means has ultimate goal increasing quality life. by which can be achieved briefly divided into prophylactic curative, depending phase condition patient is. We thus reiterate importance clinician acquiring an overview SLE microbiome, doubled in-depth physio-pathogenic interactions two (in part through much-studied gut-target organ axes—brain, heart, lung, skin), target objective being obtaining individualized, multimodal efficient management for each individual patient.
Язык: Английский
Процитировано
15
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Апрель 23, 2024
Having increased popularity during the Covid-19 pandemic, vitamin D3 is currently impressing thanks to numerous researches aimed at its interactions with body’s homeostasis. At same time, there a peak in terms of recommendations for supplementation it. Some studies focus on link between autoimmune diseases and nutritional deficiencies, especially D3. Since specialized literature children (patients 0-18 years old) far from equal informational diversity adult-centered branch, this review aims bring up date relationship microbial balance activity pediatric systemic lupus erythematosus (pSLE). The desired practical purpose resides better understanding an adequate, individualized management affected persons reduce morbidity. center summary establish impact hypovitaminosis D development evolution erythematosus. We will address aspects related two entities played by pathophysiological cascade lupus, but also risk toxicity effects when deficiency over supplemented (hypervitaminosis D). debate modulation immune function, potentiation inflammatory processes, increase oxidative stress, perfusion cognitive brain areas, seasonal incidence SLE severity. Finally, we current knowledge, post-pandemic, regarding – pSLE relationship.
Язык: Английский
Процитировано
6
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 18, 2024
Diabetes is a complex condition with rising global incidence, and its impact equally evident in pediatric practice. Regardless of whether we are dealing type 1 or 2 diabetes, the development complications following onset disease inevitable. Consequently, contemporary medicine must concentrate on understanding pathophysiological mechanisms driving systemic decline finding ways to address them. We particularly interested effects oxidative stress target cells organs, such as pancreatic islets, retina, kidneys, neurological cardiovascular systems. Our goal explore, using latest data from international scientific databases, relationship between persistence damage associated diabetes children. Additionally, highlight beneficial roles antioxidants vitamins, minerals, polyphenols, other bioactive molecules; mitigating pathogenic cascade, detailing how they intervene their properties. As result, our study provides comprehensive exploration key aspects stress-antioxidants-pediatric triad, expanding significance various diseases.
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 15, 2025
This narrative review aims to analyze and compare the current literature on multisystem inflammatory syndrome in children (MIS-C) Kawasaki disease (KD), with a focus case definitions, clinical features, diagnostic approaches, treatment strategies, outcomes. Through comprehensive of relevant studies, including screening titles, abstracts, full-text articles, key similarities differences were identified. Both MIS-C KD involve immune system dysregulation share manifestations such as rash, gastrointestinal symptoms, cardiovascular involvement, treatments often centered around immunomodulatory therapies. However, significant observed, particularly terms age distribution, demographic prevalence, presentation, criteria, primarily affecting younger being associated more prominently coronary artery abnormalities. While both diseases raise concerns about severe cardiac involvement need for intensive care, their pathogenic mechanisms have not been fully understood. Ongoing research is critical elucidating these mechanisms, refining optimizing therapeutic approaches improve outcomes affected children. comparative analysis essential advancing understanding conditions, accurately distinguishing between has implications decision-making patient management. Given overlapping yet distinct precise differentiation ensuring timely diagnosis, improving The concern among pediatric patients stems from potential complications, which underscores heightened awareness, early recognition, evidence-based strategies minimize long-term morbidity mortality.
Язык: Английский
Процитировано
0
Clinical and Experimental Medicine, Год журнала: 2023, Номер 23(7), С. 3549 - 3564
Опубликована: Июль 3, 2023
Abstract Background Many studies have shown an association between COVID-19 and autoimmune diseases (ADs). Studies on ADs also increased significantly, but there is no bibliometric analysis to summarize the ADs. The purpose of this study was perform a visual published related Methods Based Web Science Core Collection SCI-Expanded database, we utilize Excel 2019 visualization tools Co-Occurrence13.2 (COOC13.2), VOSviewer, CiteSpace, HistCite for analysis. Results A total 1736 kinds papers were included, number presented overall increasing trend. country/region with most publications USA, institution Harvard Medical School, author Yehuda Shoenfeld from Israel, journal Frontiers in Immunology . Research hotspots include immune responses (such as cytokines storm), multisystem systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis), treatment modalities hydroxychloroquine, rituximab), vaccination mechanisms autoantibodies, molecular mimicry). future research direction may be ideas NF-κB, hyperinflammation, antiphospholipid antibodies, neutrophil extracellular traps, granulocyte-macrophage colony-stimulating factor), other cross-diseases inflammatory bowel disease, chronic mucocutaneous candidiasis, acute respiratory distress syndrome). Conclusion growth rate regarding has risen sharply. Our results can help researchers grasp current status find new directions future.
Язык: Английский
Процитировано
8
Viruses, Год журнала: 2023, Номер 15(5), С. 1205 - 1205
Опубликована: Май 20, 2023
Coronavirus disease 2019 (COVID-19) in children can be compounded by concurrent diseases and immunosuppressants. For the first time, we aimed to report clinical features of COVID-19 pediatric rheumatic (PRD) Japan. Pediatric Rheumatology Association Japan members were surveyed between 1 April 2020 31 August 2022. Outcome measurements included PRD COVID-19. Questionnaire responses obtained from 38 hospitals. Thirty-one hospitals (82%) had with The female-to-male ratio these (n = 156) was 7:3, half aged 11-15 years. highest proportion accounted for juvenile idiopathic arthritis (52%), followed systemic lupus erythematosus (24%), dermatomyositis (5%), scleroderma (4%), Takayasu arteritis (3%). Of PRD, a significant majority (97%) found asymptomatic (10%) or presented mild symptoms (87%) infection. No severe cases deaths observed. Regarding use glucocorticoids, immunosuppressants, biologics treatment before COVID-19, no difference asymptomatic/mild moderate PRD. Therefore, is not threat
Язык: Английский
Процитировано
6