Medicinski podmladak,
Год журнала:
2023,
Номер
74(4), С. 15 - 20
Опубликована: Янв. 1, 2023
Introduction:
The
pathophysiological
development
of
long
COVID
(LC)
is
still
insufficiently
known.
However,
post
infection
fatigue
syndromes
were
seen
before,
among
other
pathogens
including
Epstein-Barr
virus
(EBV).
Considering
EBV
reservoir
in
COVID-19
patients,
this
review
aims
to
present
current
knowledge
related
role
LC
and
with
the
potential
diagnostic
utility.
infection:
Following
primary
lytic
epithelial
oropharyngeal
nasopharyngeal
cells
establishes
a
very
complex
mechanism
lifelong
survival
B
cells.
Latent
occasional
viral
reactivations
constantly
challenges
host's
immune
response.
In
individuals
imbalance
COVID-19,
it
could
drive
long-term
consequences.
COVID-19:
activity
has
been
shown
as
most
prevalent
human
herpesvirus
population
(41%).
Correlation
between
lymphocytopenia-induced
disability
remove
EBV,
increases
DNA
viremia
complications
have
also
reported.
COVID:
positivity
during
acute
SARS-CoV-2
predicted
presence
symptoms
up
60
days
after
COVID-19.
Association
such
brain
fog,
fatigue,
arthralgia
skin
rashes
described
sequelae
ME/CFS.
Anti-EBV
early
antigen-diffuse
(EA-D)
IgG
antibodies
detectable
two-thirds
respondents
experiencing
LC.
Increases
anti-EBNA1
levels
analyzed
months
following
onset
convalescent
serve
marker
reactivation
at
time
infection.
Some
authors
managed
show
anti-EBV
capsid
antigen
(VCA)
IgM
seropositivity
half
patients
indicating
either
coinfection
or
reactivation.
Conclusion:
As
multisystemic
illness,
without
defined
spectrum
treatment
options.
Whereas
alone
together
risk
factors
drives
symptoms,
further
prospective
studies
involving
different
cohorts
tissue
reservoirs
are
necessary
understand
underlying
biological
mechanisms.
Reproductive Biology and Endocrinology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 11, 2024
Implantation
is
the
key
initial
complex
stage
of
pregnancy.
Several
factors
are
involved
in
implantation,
but
acute
and
controlled
inflammation
has
been
shown
to
play
as
a
role.
On
other
hand,
role
viral
infections
directly
infecting
blastocyst
trophoblast
inducing
chronic
uncontrolled
disrupting
microRNAs
expression
can
make
this
review
strongly
attractive
practical.
We
aim
provide
an
overview
potential
etiology
unsuccessful
implantation
pathophysiology
through
alteration
cellular
molecular
endometrial
microenvironment.
Based
on
our
search,
first
discuss
associated
with
infection
failure.
Cell Reports,
Год журнала:
2024,
Номер
43(2), С. 113706 - 113706
Опубликована: Янв. 30, 2024
Viral
pandemics
and
epidemics
pose
a
significant
global
threat.
While
macaque
models
of
viral
disease
are
routinely
used,
it
remains
unclear
how
conserved
antiviral
responses
between
macaques
humans.
Therefore,
we
conducted
cross-species
analysis
transcriptomic
data
from
over
6,088
blood
samples
humans
infected
with
one
31
viruses.
Our
findings
demonstrate
that
irrespective
primate
or
species,
there
consistent
across
infection
phase
(acute,
chronic,
latent)
genome
type
(DNA
RNA
viruses).
Leveraging
longitudinal
experimental
challenges,
identify
virus-specific
response
kinetics
such
as
host
to
Coronaviridae
Orthomyxoviridae
infections
peaking
1-3
days
earlier
than
Filoviridae
Arenaviridae
infections.
results
underscore
studies
powerful
tool
for
understanding
pathogenesis
immune
translate
humans,
implications
therapeutic
development
pandemic
preparedness.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5845 - 5845
Опубликована: Май 28, 2024
The
Epstein-Barr
virus
(EBV)
is
frequently
found
in
endomyocardial
biopsies
(EMBs)
from
patients
with
heart
failure,
but
the
detection
of
EBV-specific
DNA
has
not
been
associated
progressive
hemodynamic
deterioration.
In
this
paper,
we
investigate
use
targeted
next-generation
sequencing
(NGS)
to
detect
EBV
transcripts
and
their
correlation
myocardial
inflammation
EBV-positive
failure
reduced
ejection
fraction
(HFrEF).
Forty-four
HFrEF
positive
varying
degrees
were
selected.
EMBs
enriched
using
a
custom
hybridization
capture-based
workflow
and,
subsequently,
sequenced
by
NGS.
short-read
revealed
presence
17
patients,
which
11
had
only
latent
genes
6
presented
lytic
transcription.
immunohistochemical
staining
for
CD3
American Journal of Reproductive Immunology,
Год журнала:
2024,
Номер
92(3)
Опубликована: Сен. 1, 2024
Chronic
endometritis
(CE)
is
a
frequent
pathological
condition
that
defined
as
localized
inflammation
in
the
endometrium.
Some
adverse
fertility
consequences
such
recurrent
miscarriage
and
failure
of
implantation
are
associated
with
chronic
endometritis.
On
one
hand,
plays
an
important
role
pathogenesis
endometritis,
on
other
viral
infections
inducing
can
make
this
review
strongly
attractive
practical.
We
set
out
to
provide
overview
potential
etiology
CE
pathophysiology
through
alteration
endometrial
microenvironment
its
association
infertility.
To
best
our
knowledge,
first
demonstrate
infection
whether
or
not
ultimately
role..
Neuroscience Insights,
Год журнала:
2024,
Номер
19
Опубликована: Янв. 1, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
a
novel
coronavirus,
emerged
in
December
2019,
sparking
global
health
crisis.
While
initially
recognized
as
illness,
it
has
become
evident
that
Coronavirus
disease
2019
(COVID-19)
also
affects
the
central
nervous
system.
This
comprehensive
review
focuses
on
neurological
manifestations
of
COVID-19
and
its
impact
patients
with
preexisting
disorders,
particularly
those
multiple
sclerosis
(MS)
receiving
disease-modifying
therapies.
Advancements
management,
including
vaccinations,
antiviral
therapy,
targeted
prophylaxis,
have
led
to
decline
incidence
severity
COVID-19.
Nevertheless,
significant
complications
persist,
advanced
MS,
who
are
highly
vulnerable
infectious
agents
like
SARS-CoV-2.
explores
evolving
understanding
MS
association
SARS-CoV-2,
encompassing
neuroinvasiveness,
pathogenesis,
severity,
outcomes.
Research
findings
reveal
substantial
implications
for
some
COVID-19,
potential
risk
relapse
severity.
A
notable
proportion
experiencing
may
manifest
new
symptoms,
experience
exacerbation
existing
or
encounter
both
simultaneously,
underscoring
diverse
effects
virus.
vaccination
therapeutics
mitigated
overall
impact,
specific
subgroups,
especially
anti-CD20
therapy
disability,
remain
at
higher
risk,
necessitating
ongoing
vigilance
tailored
care.
Life,
Год журнала:
2023,
Номер
13(7), С. 1437 - 1437
Опубликована: Июнь 25, 2023
Neuroinflammation
can
be
triggered
by
microbial
products
disrupting
immune
regulation.
In
this
study,
we
investigated
the
levels
of
IgG1,
IgG2,
IgG3,
and
IgG4
subclasses
against
heat
shock
protein
(HSP)70533-545
peptide
lipopentapeptide
(MAP_Lp5)
derived
from
Mycobacterium
avium
subsp.
paratuberculosis
(MAP)
in
blood
samples
Japanese
Italian
individuals
with
relapsing
remitting
multiple
sclerosis
(MS).
Additionally,
examined
impact
on
MOG-induced
experimental
autoimmune
encephalomyelitis
(EAE).
A
total
130
subjects
were
retrospectively
analyzed
using
indirect
ELISA
method.
Furthermore,
a
group
C57BL/6J
mice
received
immunization
MAP_HSP70533-545
two
weeks
prior
to
active
induction
MOG35-55
EAE.
The
results
revealed
significantly
robust
antibody
response
serum
both
MS
patients
compared
their
respective
control
groups.
Moreover,
heightened
antibodies
specific
MAP
antigens
correlated
severity
disease.
EAE
that
immunized
exhibited
more
severe
disease
symptoms
increased
reactivity
MOG35-55-specific
T-cell
untreated
mice.
These
findings
provide
evidence
suggesting
potential
link
between
development
or
exacerbation
MS,
particularly
subgroup
elevated
levels.
Medicinski podmladak,
Год журнала:
2023,
Номер
74(4), С. 15 - 20
Опубликована: Янв. 1, 2023
Introduction:
The
pathophysiological
development
of
long
COVID
(LC)
is
still
insufficiently
known.
However,
post
infection
fatigue
syndromes
were
seen
before,
among
other
pathogens
including
Epstein-Barr
virus
(EBV).
Considering
EBV
reservoir
in
COVID-19
patients,
this
review
aims
to
present
current
knowledge
related
role
LC
and
with
the
potential
diagnostic
utility.
infection:
Following
primary
lytic
epithelial
oropharyngeal
nasopharyngeal
cells
establishes
a
very
complex
mechanism
lifelong
survival
B
cells.
Latent
occasional
viral
reactivations
constantly
challenges
host's
immune
response.
In
individuals
imbalance
COVID-19,
it
could
drive
long-term
consequences.
COVID-19:
activity
has
been
shown
as
most
prevalent
human
herpesvirus
population
(41%).
Correlation
between
lymphocytopenia-induced
disability
remove
EBV,
increases
DNA
viremia
complications
have
also
reported.
COVID:
positivity
during
acute
SARS-CoV-2
predicted
presence
symptoms
up
60
days
after
COVID-19.
Association
such
brain
fog,
fatigue,
arthralgia
skin
rashes
described
sequelae
ME/CFS.
Anti-EBV
early
antigen-diffuse
(EA-D)
IgG
antibodies
detectable
two-thirds
respondents
experiencing
LC.
Increases
anti-EBNA1
levels
analyzed
months
following
onset
convalescent
serve
marker
reactivation
at
time
infection.
Some
authors
managed
show
anti-EBV
capsid
antigen
(VCA)
IgM
seropositivity
half
patients
indicating
either
coinfection
or
reactivation.
Conclusion:
As
multisystemic
illness,
without
defined
spectrum
treatment
options.
Whereas
alone
together
risk
factors
drives
symptoms,
further
prospective
studies
involving
different
cohorts
tissue
reservoirs
are
necessary
understand
underlying
biological
mechanisms.
