Development of long COVID as a consequence of the complex relationship between Epstein-Barr virus and our immune system DOI Creative Commons
Ana Banko

Medicinski podmladak, Journal Year: 2023, Volume and Issue: 74(4), P. 15 - 20

Published: Jan. 1, 2023

Introduction: The pathophysiological development of long COVID (LC) is still insufficiently known. However, post infection fatigue syndromes were seen before, among other pathogens including Epstein-Barr virus (EBV). Considering EBV reservoir in COVID-19 patients, this review aims to present current knowledge related role LC and with the potential diagnostic utility. infection: Following primary lytic epithelial oropharyngeal nasopharyngeal cells establishes a very complex mechanism lifelong survival B cells. Latent occasional viral reactivations constantly challenges host's immune response. In individuals imbalance COVID-19, it could drive long-term consequences. COVID-19: activity has been shown as most prevalent human herpesvirus population (41%). Correlation between lymphocytopenia-induced disability remove EBV, increases DNA viremia complications have also reported. COVID: positivity during acute SARS-CoV-2 predicted presence symptoms up 60 days after COVID-19. Association such brain fog, fatigue, arthralgia skin rashes described sequelae ME/CFS. Anti-EBV early antigen-diffuse (EA-D) IgG antibodies detectable two-thirds respondents experiencing LC. Increases anti-EBNA1 levels analyzed months following onset convalescent serve marker reactivation at time infection. Some authors managed show anti-EBV capsid antigen (VCA) IgM seropositivity half patients indicating either coinfection or reactivation. Conclusion: As multisystemic illness, without defined spectrum treatment options. Whereas alone together risk factors drives symptoms, further prospective studies involving different cohorts tissue reservoirs are necessary understand underlying biological mechanisms.

Language: Английский

The role of viral infection in implantation failure: direct and indirect effects DOI Creative Commons
Marzieh Rezaei, Mohsen Moghoofei

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 11, 2024

Implantation is the key initial complex stage of pregnancy. Several factors are involved in implantation, but acute and controlled inflammation has been shown to play as a role. On other hand, role viral infections directly infecting blastocyst trophoblast inducing chronic uncontrolled disrupting microRNAs expression can make this review strongly attractive practical. We aim provide an overview potential etiology unsuccessful implantation pathophysiology through alteration cellular molecular endometrial microenvironment. Based on our search, first discuss associated with infection failure.

Language: Английский

Citations

1
Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans DOI Creative Commons
Kalani Ratnasiri, Hong Zheng, Jiaying Toh

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(2), P. 113706 - 113706

Published: Jan. 30, 2024

Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses between macaques humans. Therefore, we conducted cross-species analysis transcriptomic data from over 6,088 blood samples humans infected with one 31 viruses. Our findings demonstrate that irrespective primate or species, there consistent across infection phase (acute, chronic, latent) genome type (DNA RNA viruses). Leveraging longitudinal experimental challenges, identify virus-specific response kinetics such as host to Coronaviridae Orthomyxoviridae infections peaking 1-3 days earlier than Filoviridae Arenaviridae infections. results underscore studies powerful tool for understanding pathogenesis immune translate humans, implications therapeutic development pandemic preparedness.

Language: Английский

Citations

0
Epstein-Barr Virus Lytic Transcripts Correlate with the Degree of Myocardial Inflammation in Heart Failure Patients DOI Open Access

Christian Baumeier,

Dominik Harms,

Britta Altmann

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5845 - 5845

Published: May 28, 2024

The Epstein-Barr virus (EBV) is frequently found in endomyocardial biopsies (EMBs) from patients with heart failure, but the detection of EBV-specific DNA has not been associated progressive hemodynamic deterioration. In this paper, we investigate use targeted next-generation sequencing (NGS) to detect EBV transcripts and their correlation myocardial inflammation EBV-positive failure reduced ejection fraction (HFrEF). Forty-four HFrEF positive varying degrees were selected. EMBs enriched using a custom hybridization capture-based workflow and, subsequently, sequenced by NGS. short-read revealed presence 17 patients, which 11 had only latent genes 6 presented lytic transcription. immunohistochemical staining for CD3

Language: Английский

Citations

0
Viral Infection in Endometritis: Is There an Important Role or Not? DOI
Hatav Ghasemi Tehrani, Marzieh Rezaei, Ferdous Mehrabian

et al.

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 92(3)

Published: Sept. 1, 2024

Chronic endometritis (CE) is a frequent pathological condition that defined as localized inflammation in the endometrium. Some adverse fertility consequences such recurrent miscarriage and failure of implantation are associated with chronic endometritis. On one hand, plays an important role pathogenesis endometritis, on other viral infections inducing can make this review strongly attractive practical. We set out to provide overview potential etiology CE pathophysiology through alteration endometrial microenvironment its association infertility. To best our knowledge, first demonstrate infection whether or not ultimately role..

Language: Английский

Citations

0
Multiple Sclerosis and COVID-19: An Overview on Risk, Severity, and Association With Disease Modifying Therapies DOI Creative Commons
Mary Hollist,

Abraham Hollist,

Katherine Au

et al.

Neuroscience Insights, Journal Year: 2024, Volume and Issue: 19

Published: Jan. 1, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, emerged in December 2019, sparking global health crisis. While initially recognized as illness, it has become evident that Coronavirus disease 2019 (COVID-19) also affects the central nervous system. This comprehensive review focuses on neurological manifestations of COVID-19 and its impact patients with preexisting disorders, particularly those multiple sclerosis (MS) receiving disease-modifying therapies. Advancements management, including vaccinations, antiviral therapy, targeted prophylaxis, have led to decline incidence severity COVID-19. Nevertheless, significant complications persist, advanced MS, who are highly vulnerable infectious agents like SARS-CoV-2. explores evolving understanding MS association SARS-CoV-2, encompassing neuroinvasiveness, pathogenesis, severity, outcomes. Research findings reveal substantial implications for some COVID-19, potential risk relapse severity. A notable proportion experiencing may manifest new symptoms, experience exacerbation existing or encounter both simultaneously, underscoring diverse effects virus. vaccination therapeutics mitigated overall impact, specific subgroups, especially anti-CD20 therapy disability, remain at higher risk, necessitating ongoing vigilance tailored care.

Language: Английский

Citations

0
Mycobacterium avium subsp. paratuberculosis Antigens Elicit a Strong IgG4 Response in Patients with Multiple Sclerosis and Exacerbate Experimental Autoimmune Encephalomyelitis DOI Creative Commons
Davide Cossu, Yuji Tomizawa, Kazumasa Yokoyama

et al.

Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1437 - 1437

Published: June 25, 2023

Neuroinflammation can be triggered by microbial products disrupting immune regulation. In this study, we investigated the levels of IgG1, IgG2, IgG3, and IgG4 subclasses against heat shock protein (HSP)70533-545 peptide lipopentapeptide (MAP_Lp5) derived from Mycobacterium avium subsp. paratuberculosis (MAP) in blood samples Japanese Italian individuals with relapsing remitting multiple sclerosis (MS). Additionally, examined impact on MOG-induced experimental autoimmune encephalomyelitis (EAE). A total 130 subjects were retrospectively analyzed using indirect ELISA method. Furthermore, a group C57BL/6J mice received immunization MAP_HSP70533-545 two weeks prior to active induction MOG35-55 EAE. The results revealed significantly robust antibody response serum both MS patients compared their respective control groups. Moreover, heightened antibodies specific MAP antigens correlated severity disease. EAE that immunized exhibited more severe disease symptoms increased reactivity MOG35-55-specific T-cell untreated mice. These findings provide evidence suggesting potential link between development or exacerbation MS, particularly subgroup elevated levels.

Language: Английский

Citations

1
Development of long COVID as a consequence of the complex relationship between Epstein-Barr virus and our immune system DOI Creative Commons
Ana Banko

Medicinski podmladak, Journal Year: 2023, Volume and Issue: 74(4), P. 15 - 20

Published: Jan. 1, 2023

Introduction: The pathophysiological development of long COVID (LC) is still insufficiently known. However, post infection fatigue syndromes were seen before, among other pathogens including Epstein-Barr virus (EBV). Considering EBV reservoir in COVID-19 patients, this review aims to present current knowledge related role LC and with the potential diagnostic utility. infection: Following primary lytic epithelial oropharyngeal nasopharyngeal cells establishes a very complex mechanism lifelong survival B cells. Latent occasional viral reactivations constantly challenges host's immune response. In individuals imbalance COVID-19, it could drive long-term consequences. COVID-19: activity has been shown as most prevalent human herpesvirus population (41%). Correlation between lymphocytopenia-induced disability remove EBV, increases DNA viremia complications have also reported. COVID: positivity during acute SARS-CoV-2 predicted presence symptoms up 60 days after COVID-19. Association such brain fog, fatigue, arthralgia skin rashes described sequelae ME/CFS. Anti-EBV early antigen-diffuse (EA-D) IgG antibodies detectable two-thirds respondents experiencing LC. Increases anti-EBNA1 levels analyzed months following onset convalescent serve marker reactivation at time infection. Some authors managed show anti-EBV capsid antigen (VCA) IgM seropositivity half patients indicating either coinfection or reactivation. Conclusion: As multisystemic illness, without defined spectrum treatment options. Whereas alone together risk factors drives symptoms, further prospective studies involving different cohorts tissue reservoirs are necessary understand underlying biological mechanisms.

Language: Английский

Citations

0