iScience, Год журнала: 2024, Номер 28(1), С. 111551 - 111551
Опубликована: Дек. 9, 2024
Язык: Английский
Molecular Medicine, Год журнала: 2024, Номер 30(1)
Опубликована: Июнь 19, 2024
Abstract Background COVID-19 is a new infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Since outbreak in December 2019, it has an unprecedented world pandemic, leading to global human health crisis. Although SARS CoV-2 mainly affects lungs, causing interstitial pneumonia and distress syndrome, number of patients often have extensive clinical manifestations, such as gastrointestinal symptoms, cardiovascular damage renal dysfunction. Purpose This review article discusses pathogenic mechanisms provides some useful suggestions for future diagnosis, treatment prevention. Methods An English-language literature search was conducted PubMed Web Science databases up 12th April, 2024 terms “COVID-19”, “SARS CoV-2”, “cardiovascular damage”, “myocardial injury”, “myocarditis”, “hypertension”, “arrhythmia”, “heart failure” “coronary heart disease”, especially update articles 2023 2024. Salient medical literatures regarding were selected, extracted synthesized. Results The most common myocarditis pericarditis, hypertension, arrhythmia, myocardial injury failure, coronary disease, stress cardiomyopathy, ischemic stroke, blood coagulation abnormalities, dyslipidemia. Two important may be direct viral cytotoxicity well indirect hyperimmune responses body infection. Conclusions Cardiovascular portends worse prognosis. underlying pathophysiological related are not completely clear, two SARSCoV-2 infection responses.
Язык: Английский
Процитировано
8
Viruses, Год журнала: 2025, Номер 17(4), С. 569 - 569
Опубликована: Апрель 15, 2025
SARS-CoV-2 has demonstrated a remarkable capacity for immune evasion. While initial studies focused on the Wuhan variant and adaptive immunity, later emerging strains such as Omicron exhibit mutations that may alter their immune-modulatory properties. We performed comprehensive review of evasion mechanisms associated with viral proteins to focus evolutionary dynamics modulation. systematically analyzed compared impact all currently known type I interferon (IFN) responses using dual-luciferase reporter assay carrying an interferon-inducible promoter. Results revealed Nsp1, Nsp5, Nsp14, ORF6 are potent IFN inhibitors conserved across strains. Notably, we identified strain-specific differences, Nsp6 Spike exhibiting enhanced suppression in Omicron, whereas Envelope protein largely retained this function. To extend these findings, investigated selected primary human endothelial cells also observed differences response higher expressing strain variant, suggesting Omicron’s adaptational contribute damped course pandemic’s trajectory.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Май 13, 2025
Vaccine adjuvants, as key components in enhancing vaccine immunogenicity, play a vital role modern vaccinology. This review systematically examines the historical evolution and mechanisms of with particular emphasis on innovative advancements aluminum-based emulsion-based nucleic acid adjuvants (e.g., CpG oligonucleotides). Specifically, aluminum enhance immune responses through particle formation/antigen adsorption, inflammatory cascade activation, T-cell stimulation. Emulsion amplify immunogenicity via antigen depot effects localized inflammation, while like oligonucleotides directly activate B cells dendritic to promote Th1-type memory generation. The article further explores prospective applications these novel combating emerging pathogens (including influenza SARS-CoV-2), particularly highlighting their significance improving potency durability. Moreover, this underscores critical importance adjuvant development next-generation design provides theoretical foundations for creating safer, effective adjuvant.
Язык: Английский
Процитировано
0
Computers in Biology and Medicine, Год журнала: 2024, Номер 183, С. 109343 - 109343
Опубликована: Ноя. 4, 2024
Язык: Английский
Процитировано
3
Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)
Опубликована: Авг. 15, 2024
Abstract Deciphering the initial steps of SARS-CoV-2 infection, that influence COVID-19 outcomes, is challenging because animal models do not always reproduce human biological processes and in vitro systems recapitulate histoarchitecture cellular composition respiratory tissues. To address this, we developed an innovative ex vivo model whole lung infection with SARS-CoV-2, leveraging a transplantation technique. Through single-cell RNA-seq, identified alveolar monocyte-derived macrophages (AMs MoMacs) were targets virus. Exposure isolated AMs, MoMacs, classical monocytes non-classical (ncMos) to variants revealed while all subsets responded, MoMacs produced higher levels inflammatory cytokines than ncMos contributed least. A Wuhan lineage appeared be more potent D614G virus, dose-dependent manner. Amidst ambiguity literature regarding cell target, our study reveals AMs are dominant primary entry points for suggests their responses may conduct subsequent injury, depending on abundance, viral strain dose. Interfering virus interaction should considered prophylactic strategies.
Язык: Английский
Процитировано
1
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июнь 14, 2024
Язык: Английский
Процитировано
0
iScience, Год журнала: 2024, Номер 28(1), С. 111551 - 111551
Опубликована: Дек. 9, 2024
Язык: Английский
Процитировано
0