Journal of Food and Drug Analysis,
Год журнала:
2024,
Номер
32(4), С. 412 - 427
Опубликована: Дек. 14, 2024
Carbon
nanotubes
(CNTs)
has
emerged
as
a
promising
nanomaterial
with
wide
range
of
potential
applications
due
to
their
unique
structural,
mechanical,
electrical,
and
thermal
properties.
However,
numerous
obstacles
must
be
overcome
for
CNTs
used
successfully,
including
low
solubility,
aggregation,
lack
specialized
functions.
Diverse
techniques
have
been
developed
the
manufacture,
purification,
functionalization
in
order
these
issues.
The
main
aim
this
review
article
is
provide
brief
knowledge
about
strategies
use
revolutionized
drug
delivery.
Prepare
cannot
directly
carrier
molecules
presence
impurities,
so
purification
an
essential
aspect
use.
In
addition,
various
procedures
are
frequently
conjugation
other
benefits,
such
reduced
toxicity
targeted
Their
nano
needle
structure
can
penetrate
any
cell
without
damaging
it
improved
efficiency
delivery,
cancer
identification,
anticancer
molecule
antifungal
treatment,
transdermal
approaches.
This
nanostructure
also
some
antimicrobial
activity,
agents
shows
synergistic
response.
Journal of Genetic Engineering and Biotechnology,
Год журнала:
2024,
Номер
22(3), С. 100400 - 100400
Опубликована: Июль 26, 2024
Aptamers
are
single-stranded
oligonucleotide
sequences
capable
of
binding
to
specific
ligands
with
high
affinity.
In
this
manner,
they
like
antibodies
but
have
advantages
such
as
lower
manufacturing
costs,
immunogenicity,
fewer
batch-to-batch
differences,
a
longer
shelf
life,
tolerance
different
molecular
milieus,
and
greater
number
potential
targets.
Due
their
special
features,
been
used
in
drug
delivery,
biosensor
technology,
therapy,
diagnostics.
The
methodology
that
allowed
its
production
was
the
"Systematic
Evolution
Ligands
by
Exponential
enrichment"
(SELEX).
Unfortunately,
traditional
protocol
is
time-consuming
laborious.
Therefore,
numerous
variants
considerable
optimization
steps
developed,
nonetheless,
there
still
challenges
achieving
real
applications
clinical
field.
Among
them,
control
vivo
activities,
fast
renal
filtration,
degradation
nucleases
toxicity
testing.
This
review
focuses
on
current
technologies
based
SELEX,
critical
factors
for
successful
aptamer
selection,
upcoming
biomedical
biotechnological
applications.
Cancer
screening
techniques
aim
to
detect
premalignant
lesions
and
enable
early
intervention
delay
the
onset
of
cancer
while
keeping
incidence
constant.
Technology
advancements
have
led
development
powerful
tools
such
as
microfluidic
technology,
artificial
intelligence,
machine
learning
algorithms,
electrochemical
biosensors
aid
in
detection.
Non-invasive
methods
like
virtual
colonoscopy
endoscopic
ultrasonography
also
been
developed
provide
comprehensive
pictures
organs
early.
This
review
article
provides
an
overview
recent
advances
biomarkers
through
a
narrative
literature
search.
Microfluidic
devices
easy
handling
sub-microliter
volumes
become
promising
tool
for
detection,
drug
screening,
modeling
angiogenesis
metastasis
research.
Machine
intelligence
shown
high
accuracy
oncology-related
diagnostic
imaging,
reducing
manual
steps
lesion
detection
providing
standardized
accurate
results,
with
potential
global
standardization
areas
colon
polyps,
breast
cancer,
primary
metastatic
brain
cancer.
A
biomarker-based
diagnosis
is
effective
therapy,
integrated
nanoparticles
offer
multiplexing
amplification
capabilities.
Understanding
these
advanced
technologies'
basics,
achievements,
challenges
crucial
advancing
their
use
oncology.
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(8)
Опубликована: Май 28, 2024
In
this
study,
an
ultrasensitive
label‐free
electrochemical
immunosensor
based
on
Ti
3
C
2
T
x
(Mxene)
with
a
2D‐layered
morphology
has
been
proposed
for
the
detection
of
EpCAM
antigen.
A
hydrothermal
method
is
employed
synthesis
by
using
less
toxic
exfoliating
reagent,
NaBF
4
.
The
bioelectrode,
BSA/anti‐EpCAM/Ti
@ITO,
fabricated
electrophoretic
deposition
onto
ITO
electrode,
followed
immobilization
antibody.
Electrochemical
response
studies
reveal
that
shows
high
sensitivity
29.22
μA
fg
−1
ml
cm
−2
and
wide
linear
range
from
0.1
fg/ml
to
100
ng/ml,
antigen
detection.
Further,
good
stability
additional
advantage
in
serum
samples.
Biosensors,
Год журнала:
2025,
Номер
15(4), С. 222 - 222
Опубликована: Март 31, 2025
The
growing
demand
for
real-time,
non-invasive,
and
cost-effective
health
monitoring
has
driven
significant
advancements
in
portable
point-of-care
testing
(POCT)
devices.
Among
these,
optical
biosensors
have
emerged
as
promising
tools
the
detection
of
critical
biomarkers
such
uric
acid
(UA)
blood
glucose.
Different
transduction
methods,
like
fluorescence,
surface
plasmon
resonance
(SPR),
colorimetric
approaches,
are
talked
about,
with
a
focus
on
how
sensitive,
specific,
they
are.
Despite
considerable
advancements,
several
challenges
persist,
including
sensor
stability,
miniaturization,
interference
effects,
need
calibration-free
operation.
This
review
also
explores
issues
related
to
cost-effectiveness,
data
integration,
wireless
connectivity
remote
monitoring.
further
examines
regulatory
considerations
commercialization
aspects
biosensors,
addressing
gap
between
research
developments
clinical
implementation.
Future
perspectives
emphasize
integration
artificial
intelligence
(AI)
healthcare
improved
diagnostics,
alongside
development
wearable
implantable
continuous
Innovative
potential
change
way
people
manage
their
by
quickly
accurately
measuring
glucose
levels.
is
especially
true
decentralized
solutions
grows.
By
critically
evaluating
existing
work
exploring
limitations
opportunities
field,
this
will
help
guide
more
efficient,
accessible,
reliable
POCT
devices
that
can
improve
patient
outcomes
quality
life.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(26), С. 6342 - 6350
Опубликована: Янв. 1, 2024
The
synthesis
and
application
of
microscale
metal–organic
framework
(MOF)/enzyme
composite
particles
as
a
novel
detection
probe
to
enhance
the
sensitivity
ELISA.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Окт. 11, 2024
Lung
cancer
is
frequently
detected
in
an
advanced
stage
and
has
unfavourable
prognosis.
Conventional
therapies
are
ineffective
for
the
treatment
of
metastatic
lung
cancer.
While
certain
molecular
targets
have
been
identified
as
having
a
positive
response,
absence
appropriate
drug
carriers
prevents
their
effective
utilization.
cell-derived
exosomes
(LCCDEs)
gained
attention
involvement
development
cancer,
well
potential
use
diagnosing,
treating,
predicting
outcome
This
due
to
biological
roles
inherent
ability
transport
biomolecules
from
donor
cells.
cancer-associated
extracellular
vesicles
(LCCDEVs)
enhance
cell
proliferation
metastasis,
influence
angiogenesis,
regulate
immune
responses
against
tumours
during
control
resistance
treatment,
increasingly
recognised
crucial
element
liquid
biopsy
evaluations
detection
Therapeutic
exosomes,
which
possess
intercellular
communication
capabilities,
vehicles
targeted
delivery
precision
medicine
tumours.
exceptional
biocompatibility,
minimal
immunogenicity,
low
toxicity,
prolonged
circulation
bloodstream,
biodegradability,
traverse
different
barriers.
Currently,
multiple
studies
being
conducted
create
new
means
diagnosing
outcomes
using
LCCDEs,
develop
techniques
utilizing
medication
delivery.
paper
provides
overview
current
state
wide
range
applications
LCCDEs.
The
encouraging
findings
technologies
suggest
that
utilization
LCCDEs
holds
promise
clinical
patients.
Bulletin of Siberian Medicine,
Год журнала:
2024,
Номер
23(2), С. 162 - 182
Опубликована: Июль 11, 2024
The
aim
of
this
review
was
to
analyze
the
accumulated
data
on
use
mass
spectrometry
in
diagnosing,
treating,
and
prognosing
cancer
from
perspective
precision
medicine.
Currently,
universally
accepted
methods
for
early
diagnosis
are
not
available,
primarily
due
low
molecular
specificity
pathological
changes
at
stages
development.
Additionally,
existing
diagnostic
modalities
notably
limited
sensitivity.
However,
detection
is
imperative
selection
most
suitable
treatment
strategy
its
successful
implementation.
In
realm
oncology,
approaches
show
great
potential
advancement
utilization.
Mass
becoming
an
indispensable
tool
basic
applied
research
sensitivity,
specificity,
accuracy.
It
allows
efficient
analysis
complex
biological
compounds,
even
concentrations.
Moreover,
contemporary
technology
capable
automating
analysis,
thereby
facilitating
diverse
clinical
applications
diagnosis,
drug
therapy
selection,
assistance
surgical
oncologists
operating
room.
Considering
all
these
characteristics
advantages,
samples
can
be
defined
as
some
promising
dynamically
developing
tools
medicine,
they
providing
clinically
valuable
information
based
omics
technologies,
taking
into
account
personal
patient.
Over
next
decade,
introduction
spectrometry-based
practice
principles
medicine
expected
optimize
personalized
strategies
patients
provide
significant
economic
benefits
by
reducing
morbidity,
disability,
mortality.This
comprehensive
presents
65
scientific
publications,
highlighting
results
experimental
studies
utilizing
diagnosing
cancer,
investigating
underlying
mechanisms
disease
development,
evaluating
efficacy
therapeutic
interventions.
encompasses
original
articles
published
January
1,
2018
November
30,
2023.
majority
back
a
monitoring.
Broadening
application
techniques
field
oncology
holds
promise
represents
relevant
area
future
research.
