Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 309 - 362
Опубликована: Ноя. 29, 2024
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1201 - 1201
Опубликована: Сен. 13, 2024
Chitosan is the most commonly investigated functional cationic biopolymer in a wide range of medical applications due to its promising properties such as biocompatibility, biodegradability, and bioadhesivity, well numerous bioactive properties. Within last three decades, chitosan derivatives have been biomaterials for drug vaccine delivery systems, besides their Due groups structure, it possible tailor systems with desired There has great interest application chitosan-based also prevention treatment infectious diseases, specifically antimicrobial, antiviral, immunostimulatory effects. In this review, recent diseases are reviewed, possibilities limitations regards technical regulatory aspects discussed. Finally, future perspectives on utilization biomaterial
Язык: Английский
Процитировано
8
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6589 - 6602
Опубликована: Июль 1, 2024
Abstract: Orthopedic infection is one of the most intractable orthopedic problems. Bacteria resistant to antibiotics also develop gradually. Chitosan widely used in Biomedical field because its high biocompatibility, biodegradability, and antibacterial activity. Chitosan-based drug delivery systems are frequently utilized produce controlled medication release. When combined with antibiotics, synergistic effects can be achieved. nanoparticles applications systems. The focus this review provide information on new methods being developed for chitosan-based bone treatment, including chitosan purposes, Ch-loaded metal, as immune adjuvants. It may Provide ideas fundamental research prospects future clinical infections. Keywords: nanoparticles, infection, staphylococcus aureus
Язык: Английский
Процитировано
5
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 12, 2024
Biomaterials are substances that can be injected, implanted, or applied to the surface of tissues in biomedical applications and have ability interact with biological systems initiate therapeutic responses. Biomaterial-based vaccine delivery possess robust packaging capabilities, enabling sustained localized drug release at target site. Throughout process, they contribute protecting, stabilizing, guiding immunogen while also serving as adjuvants enhance efficacy. In this article, we provide a comprehensive review contributions biomaterials advancement development. We begin by categorizing biomaterial types properties, detailing their reprocessing strategies, exploring several common systems, such polymeric nanoparticles, lipid hydrogels, microneedles. Additionally, investigated how physicochemical properties routes influence immune Notably, delve into design considerations adjuvants, showcasing application development for cancer, acquired immunodeficiency syndrome, influenza, corona virus disease 2019 (COVID-19), tuberculosis, malaria, hepatitis B. review, highlight successful instances where enhanced efficacy discuss limitations future directions immunotherapy. This aims offer researchers understanding stimulate further progress related fields.
Язык: Английский
Процитировано
4
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 132 - 132
Опубликована: Янв. 18, 2025
Background/Objectives: Helicobacter pylori is the leading cause of chronic gastritis, peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoma. Due to emerging problems with antibiotic treatment against H. in clinical practice, vaccination has gained more interest. Oral immunization considered a promising approach for preventing initial colonization this bacterium gastrointestinal tract, establishing first line defense at mucosal surfaces. Chitosan nanoparticles can be exploited effectively oral vaccine delivery due their stability, simplicity target accessibility, beneficial mucoadhesive immunogenic properties. Methods: In study, new multi-epitope pDNA- recombinant protein-based vaccines incorporating multiple antigens were produced encapsulated chitosan intramuscular administration. The induced immune response was assessed through levels antigen-specific IgGs, secreted SIgA, cytokines (IL-2, IL-10, IFN-γ) immunized BALB/C mice. Results: Intramuscular administration both pDNA efficiently stimulated production specific IgG2a IgG1, which supported by levels. immunizations either or protein revealed high SIgA levels, suggesting effective immunization, contrasting immunizations, did not induce SIgA. Conclusions: These findings indicate that into are candidates eradicating mitigating associated diseases humans.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142055 - 142055
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(8), С. 5037 - 5056
Опубликована: Май 24, 2024
The oral and nasal cavities serve as critical gateways for infectious pathogens, with microorganisms primarily gaining entry through these routes. Our first line of defense against invaders is the mucosal membrane, a protective barrier that shields body's internal systems from infection while also contributing to vital functions like air nutrient intake. One key features this its ability protect physiological system pathogens. Additionally, tolerance plays crucial role in maintaining homeostasis by regulating pH water balance within body. Recognizing importance barrier, researchers have developed various formulations enhance immune response. Mucosal vaccines, example, deliver antigens directly tissues, triggering local stimulation ultimately inducing systemic immunity. Studies shown lipid-based such liposomes virosomes can effectively elicit both responses. Furthermore, mucoadhesive polymeric particles, their prolonged delivery target sites, demonstrated an enhanced This Review delves into material selection approaches optimizing
Язык: Английский
Процитировано
3
Опубликована: Янв. 1, 2024
Chitosan, derived from crustacean shells, presents a biocompatible and biodegradable material with wide-ranging applications in medical fields, including drug delivery, wound healing, tissue regeneration. By harnessing chitosan derivatives, particularly the form of nanochitosan nanoparticles, its aqueous solubility limitation can be overcome, enabling controlled release immunomodulation for therapeutic purposes. This versatile nanomaterial exhibits substantial antimicrobial properties against bacteria, viruses, fungi, achieved through interactions microbial cell membranes, modulation membrane permeability, DNA binding, potential electron transport chain modulation, rendering it promising tool health care biomedicine. Moreover, proves effective hindering fungal growth contamination, offering multifaceted approach to combat infections across various contexts. In aquaculture, emerges as pivotal solution water quality management, nutrient disease control, contributing resilience aquatic organisms while ensuring sustainable practices within industry.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106309 - 106309
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Nanomedicine, Год журнала: 2024, Номер unknown, С. 1 - 3
Опубликована: Ноя. 6, 2024
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 309 - 362
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
0