Current Microbiology, Год журнала: 2024, Номер 81(10)
Опубликована: Авг. 20, 2024
Язык: Английский
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 6, 2025
Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing landscape of cancer therapeutics an encouraging manner. Among diverse immunotherapy strategies, mRNA vaccines have ushered a new era for therapeutic management malignant diseases, primarily due to their impressive impact on COVID-19 pandemic. In this comprehensive review, we offer systematic overview vaccines, focusing optimization structural design, crucial role delivery materials, and administration route. Additionally, summarize preclinical studies clinical trials provide valuable insights into current status treatment. Furthermore, delve discussion significant challenges facing development tumor vaccines. These encompass both intrinsic external factors that are closely intertwined with successful application innovative approach. To pave way more promising future treatments, deeper understanding immunological mechanisms, increasing number high-quality trials, well-established manufacturing platform crucial. Collaborative efforts between scientists, clinicians, industry engineers essential achieving these goals.
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100305 - 100305
Опубликована: Ноя. 18, 2024
Язык: Английский
Процитировано
6
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
5
Vaccine, Год журнала: 2025, Номер 52, С. 126902 - 126902
Опубликована: Фев. 26, 2025
Язык: Английский
Процитировано
0
Journal of Advanced Research, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Potato (Solanum tuberosum L.) is the fourth most important food crop after rice, wheat and maize in world with potential to feed world's population, potato a major staple many countries. Currently, grown more than 100 countries consumed by 1 billion people worldwide, global annual output exceeds 300 million tons. With rapid increase will play key role supply. These aspects have driven scientists genetically engineer for yield nutrition improvement.
Язык: Английский
Процитировано
3
Biomolecules, Год журнала: 2024, Номер 14(7), С. 767 - 767
Опубликована: Июнь 27, 2024
The subcellular localization of messenger RNAs (mRNAs) is a pivotal aspect biomolecules, tightly linked to gene regulation and protein synthesis, offers innovative insights into disease diagnosis drug development in the field biomedicine. Several computational methods have been proposed predict mRNAs within cells. However, there remains deficiency accuracy these predictions. In this study, we propose an mRCat predictor based on gradient boosting tree algorithm specifically whether are localized nucleus or cytoplasm. This firstly uses large language models thoroughly explore hidden information sequences then integrates traditional sequence features collectively characterize mRNA sequences. Finally, it employs CatBoost as base classifier for predicting mRNAs. experimental validation independent test set demonstrates that obtained 0.761, F1 score 0.710, MCC 0.511, AUROC 0.751. results indicate our method has higher robustness compared other state-of-the-art methods. It anticipated offer deep biomolecular research.
Язык: Английский
Процитировано
2
Vaccines, Год журнала: 2024, Номер 12(6), С. 670 - 670
Опубликована: Июнь 17, 2024
Current mRNA vaccines are mainly administered via intramuscular injection, which induces good systemic immunity but limited mucosal immunity. Achieving through vaccination could diminish pathogen replication at the entry site and reduce interhuman transmission. However, delivering to mucosae faces challenges like degradation, poor into cells, reactogenicity. Encapsulating in extracellular vesicles may protect reactogenicity, making possible. Plant-derived from edible fruits have been investigated as carriers. Studies animals show that vehiculated orange-derived can elicit both immune responses when by oral, nasal, or routes. Once lyophilized, these products remarkable stability. The optimization of improve translation efficiency, immunogenicity, stability be obtained adjustments 5′cap region, poly-A tail, codons selection, use nucleoside analogues. Recent studies also proposed self-amplifying RNA containing an polymerase well circular constructs. Data parenterally primed demonstrate efficacy nasal immunization with non-adjuvanted protein, humans indicate combination a parenteral vaccine natural exposure same antigen provides protection reduces Hence, would beneficial least organisms pre-treated vaccines. This practice wide applications for treatment infectious diseases.
Язык: Английский
Процитировано
1
Current Microbiology, Год журнала: 2024, Номер 81(10)
Опубликована: Авг. 20, 2024
Язык: Английский
Процитировано
0