SARS-CoV-2 Vaccines: The Advantage of Mucosal Vaccine Delivery and Local Immunity

Vaccines, Год журнала: 2024, Номер 12(7), С. 795 - 795

Опубликована: Июль 18, 2024

Immunity against respiratory pathogens is often short-term, and, consequently, there an unmet need for the effective prevention of such infections. One infectious disease coronavirus 19 (COVID-19), which caused by novel Beta SARS-CoV-2 that emerged around end 2019. The World Health Organization declared illness a pandemic on 11 March 2020, and since then it has killed or sickened millions people globally. development COVID-19 systemic vaccines, impressively led to significant reduction in severity, hospitalization, mortality, contained pandemic’s expansion. However, these vaccines have not been able stop virus from spreading because restricted mucosal immunity. As result, breakthrough infections frequently occurred, new strains emerging. Furthermore, will likely continue circulate like influenza virus, co-exist with humans. upper tract nasal cavity are primary sites infection thus, mucosal/nasal vaccination induce response virus’ transmission warranted. In this review, we present status both approved those under evaluation clinical trials. our approach B-cell peptide-based applied prime-boost schedule elicit

Язык: Английский

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Longitudinal immunogenicity cohort study of SARS-CoV-2 mRNA vaccines across individuals with different immunocompromising conditions: heterogeneity in the immune response and crucial role of Omicron-adapted booster doses

EBioMedicine, Год журнала: 2025, Номер 113, С. 105577 - 105577

Опубликована: Фев. 4, 2025

Язык: Английский

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Divergence of variant antibodies following SARS-CoV-2 booster vaccines in myeloma and impact of hybrid immunity

npj Vaccines, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 27, 2024

Hematological malignancies are associated with an increased risk of complications during SARS-CoV-2 infections. Primary series or monovalent booster vaccines reduce disease severity, hospitalization, and death among multiple myeloma patients. We characterized virus-neutralizing spike-binding antibody profiles following (WA1) bivalent (WA1/BA.5) vaccination in MM Bivalent improved the breadth binding antibodies but not neutralization activity against contemporary variants. Hybrid immunity immune imprinting impact vaccine-elicited immunity.

Язык: Английский

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Impfempfehlungen bei Immunsupprimierten

rheuma plus, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

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