Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

Cell Death and Differentiation, Год журнала: 2021, Номер 28(12), С. 3199 - 3213

Опубликована: Окт. 18, 2021

SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to develop our understanding of the nature disease and its effects on human immunity. Previously, suggested that a dysregulated STAT3 pathway following SARS-Co-2 infection ultimately leads PAI-1 activation cascades pathologies. The major COVID-19-associated metabolic risks (old age, hypertension, cardiovascular diseases, diabetes, obesity) share high levels could predispose certain groups severe complications. In this review article, describe common profile is shared between all these high-risk COVID-19. This not only involves as previously described, also includes low glutamine NAD+, coupled with overproduction hyaluronan (HA). exacerbates imbalance predisposes patients pathophysiologies COVID-19, including involvement NETs (neutrophil extracellular traps) HA in lung. While hyperinflammation due proinflammatory cytokine has been frequently documented, it recently recognized immune response markedly suppressed some cases by expansion activity MDSCs (myeloid-derived suppressor cells) FoxP3+ Tregs (regulatory T cells). metabolomics profiles advanced cancer are similar, patients, aberrant activation, which promotes cancer-like metabolism. We propose deficiency overproduced central characteristic groups. suggest usage supplementation repurposing drugs prevent development pneumonia.

Язык: Английский

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The Impact of Oral Health on Respiratory Viral Infection

Dentistry Journal, Год журнала: 2021, Номер 9(4), С. 43 - 43

Опубликована: Апрель 13, 2021

Influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV-2) have caused diseases worldwide. Coronavirus disease 2019 (COVID-19) is now a global health concern requiring emergent measures. These viruses enter the human body through oral cavity infect cells. Since has complex microbiota, influence of bacteria on infection considered. Saliva immune molecules which work as front line in biophylactic mechanism considerable incidence progression viral infection. Salivary scavenger molecules, such gp340 sialic acid, been reported to exert anti-influenza activity. secretory immunoglobulin A (SIgA) potential acquire immunity against these viruses. Biological features are thought affect organs various ways. In this review, we reviewed literature addressing impact conditions infectious by

Язык: Английский

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Supplementation of L-glutamine enhanced mucosal immunity and improved hormonal status of combat-sport athletes

Journal of the International Society of Sports Nutrition, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 9, 2024

Background Maintaining proper immune function and hormone status is important for athletes to avoid upper respiratory tract infection (URTI) insufficient recovery, which detrimental sport performance health. The aim of this study was evaluate whether three-week supplementation L-glutamine could benefit the mucosal immunity hormonal combat-sport as well their rates subjective feelings well-being after intensive training.

Язык: Английский

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Novel insights into athlete physical recovery concerning lactate metabolism, lactate clearance and fatigue monitoring: A comprehensive review

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Март 25, 2025

Lactate accumulation will appear in athlete skeletal muscle after intense exercise. If the high lactate level maintains, athletes sustain fatigue and athletic capacity decline due to internal environment normal metabolism disruption. In order enhance physical recovery exercise performance high-intensity sport events, it is of great significance explore scientific intervention procedures based on quicker clearance blood This article collects classic novel literature terms metabolism, monitoring during by searching PubMed database then summarizes comprehensive insights into with corresponding figures charts. We introduce generation transformation process lactate, pathways methods for detail. The involve biochemical (oxygen inhalation, amino acids supplement, targeting free radical, alkaline reserve, vasomotion, ribose supplement), activities (exercise-mediated activities, non-exercise activities) training (interval training, altitude training) accelerate metabolism. factors blood, urine, sweat, saliva exhaled gas. hope this review can offer some significant assistance recovering improving achievements clearance.

Язык: Английский

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Association among inflammaging, body composition, physical activity, and physical function tests in physically active women

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Июль 18, 2023

Inflammaging is a phenomenon that has been associated with the development and progression of sarcopenia frailty syndrome. According to literature, on one side, increase in body fat systemic pro-inflammatory status, which consequently favors inflammaging, other regular practice physical exercise can mitigate this scenario. Therefore, here, we aimed evaluate association between inflammaging factors, both functional, group physically active older women.Seventy women (mean age 72.66 ± 6.17 years) participated observational cross-sectional were separated into eutrophic, overweight, obese groups. It was assessed: by bioimpedance-body percentage (Fat%) total (Fat kg), skeletal muscle mass (muscle), free (FFM%) (FFMkg); International Physical Activity Questionnaire (IPAQ)-the time moderate-intensity activity per week; tests-handgrip (HG), sit-up-stand-on-the-chair 5 repetitions (Sit-up) vertical squat jump test (SJ); addition determination serum cytokine concentration (IL-6, TNF-α, IL-10, IL-8), also index (BMI) calf circumference (Calf).Higher FFM% lower (both kg %) found eutrophic than The performed more weekly activity, jumped higher, presented not only higher IL-6 but an increased ratio IL-10/IL-6, IL-10/TNF-α, IL-10/IL-8 as compared values overweight group. (kg groups Interestingly, several significant negative positive correlations composition, tests, concentrations groups.While showed remarkable regulation inflammatory status associations parameters assessed, impairment regulations could be related less fat.

Язык: Английский

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Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

Nutrients, Год журнала: 2021, Номер 13(4), С. 1106 - 1106

Опубликована: Март 28, 2021

Nowadays, it is accepted that the regular practice of exercise and branched-chain amino acids supplementation (BCAAs) can benefit immune responses in older persons, prevent occurrence physical frailty (PF), cognitive decline, aging-related comorbidities. However, impact their combination (as non-pharmacological interventions) albumin inflammatory markers not fully understood. Therefore, we investigated effect a 40-week multifactorial intervention [MIP, multicomponent (ME) associated or with BCAAs] on plasma levels frail persons (≥75 years old) living at residential care homes (RCH). This study consisted prospective, naturalistic, controlled clinical trial four arms experimental (interventions-wahshout-interventions) design. The groups were ME + BCAAs (

Язык: Английский

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Better Response to Influenza Virus Vaccination in Physically Trained Older Adults Is Associated With Reductions of Cytomegalovirus-Specific Immunoglobulins as Well as Improvements in the Inflammatory and CD8+ T-Cell Profiles

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Окт. 12, 2021

Chronic cytomegalovirus (CMV) infection is a trigger factor for the development of immunosenescence and negatively impacts immune response to influenza virus vaccination (IVV) in older adults. However, role physical exercise training this context unknown. Thus, aim study was investigate whether regular practice combined can improve specific antibody IVV CMV-seropositive Eighty adults were distributed into two groups—non-practitioners (NP, n = 31, age 74.06 ± 6.4 years) practitioners (CET, 49, 71.7 5.8 years)—for at least 12 months. Both volunteer groups submitted blood samples collected before (pre) 30 days after (post) vaccination. Concerning IVV, higher serum levels immunoglobulin A (IgA) found CET group post- than pre-vaccination ( p < 0.01), whereas M (IgM) observed both NP 0.05) 0.001) post-vaccination as compared values. Serum G (IgG) CMV, well interleukin 6 (IL-6) IL-10, similar between time points evaluated. IL-10/IL-6 ratio that Negative correlations IgG CMV only group, pre- post-vaccination. In addition, negative IL-10 all post-vaccination, positive correlation specific-IgG group. with hemagglutination inhibition (HAI) assay, it 32.2% 32.6% responders displayed reductions serostatus 0.05 0.001, respectively) increases naive effector CD8 + T cells 0.01). from showed significant increased 0.001). summary, demonstrates improvement related an anti-inflammatory status enhancement cells, particularly associated CET.

Язык: Английский

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Uncovering anti-influenza mechanism of Ophiocordyceps sinensis using network pharmacology, molecular pharmacology, and metabolomics

Medicine, Год журнала: 2023, Номер 102(35), С. e34843 - e34843

Опубликована: Сен. 1, 2023

Ophiocordyceps sinensis is a precious Chinese traditional herb with long medicinal history. This study used UPLC-MS metabolomics to explore and compare the metabolic profiles of stroma (OSBSz), sclerotium (OSBSh), mycelium (OSBS) O analyze their differential metabolites identified potential active components. Then combined network pharmacology molecular docking mechanism anti-influenza properties. The results indicate that stroma, sclerotium, showed significant differences in metabolites. key pathways for were butanoate metabolism, thiamin alanine, aspartate glutamate citrate cycle, arginine biosynthesis. Protein-protein interaction analysis targets, including SRC, RHOA, HSP90AA1, VEGFA, ITGB1, PRKCA, ITGA1, protective in-volved PI3K-Akt, HIF-1, influenza A, Coronavirus disease 2019. core metabolite D-(-)-glutamine has high binding affinity EGFR, re-flecting multi-component multi-target system sinensis. In short, combination metabonomics, macromolecular technology provides new way research undoubtedly an important theoretical support clinical application future.

Язык: Английский

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l-Glutamine supplementation enhances glutathione peroxidase and paraoxonase-1 activities in HDL of exercising older individuals

Experimental Gerontology, Год журнала: 2021, Номер 156, С. 111584 - 111584

Опубликована: Окт. 13, 2021

Язык: Английский

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Mining Anti-Inflammation Molecules From Nippostrongylus brasiliensis-Derived Products Through the Metabolomics Approach

Frontiers in Cellular and Infection Microbiology, Год журнала: 2021, Номер 11

Опубликована: Ноя. 11, 2021

Hookworm is one type of soil-transmitted helminth, which could exert an anti-inflammatory effect in human or animal host, provides a beneficial possibility for the discovery inflammatory-related disease interventions. The identification hookworm-derived molecules urgently needed future translational research. emergence metabolomics has become powerful approach to comprehensively characterize metabolic alterations recent times. Herein, excretory and secretory products (ESPs) were collected from cultured adult worm, while small intestinal contents obtained Nippostrongylus brasiliensis ( N. , Nb)-infected mice. Through ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) platform, analysis was used explore molecules. Out 45 differential metabolites that discovered ESPs, 10 them showed potential properties, be subclassed into amino acids, furanocoumarins, linear diarylheptanoids, gamma butyrolactones, alpha-keto acids. In terms derived -infected mice, 14 out 301 demonstrate effects, possible subclassification benzylisoquinolines, quaternary ammonium salts, pyrimidines, pregnane steroids, purines, biphenyls, glycerophosphocholines. Furthermore, nine appeared both ESPs infected contents, wherein four proven show anti-inflammation namely, L-glutamine, glutamine (Gln), pyruvate, alanine-Gln (Ala-Gln). summary, we have provided method parasite-derived properties present study. This array provide clues evaluation study these

Язык: Английский

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