Unveiling the Impact of Dyes on Aquatic Ecosystems through Zebrafish – A Comprehensive Review

Environmental Research, Год журнала: 2024, Номер 261, С. 119684 - 119684

Опубликована: Июль 26, 2024

Язык: Английский

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Immunotoxicity of microplastics in fish

Fish & Shellfish Immunology, Год журнала: 2024, Номер 150, С. 109619 - 109619

Опубликована: Май 10, 2024

Язык: Английский

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Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review

Polymers, Год журнала: 2024, Номер 16(19), С. 2807 - 2807

Опубликована: Окт. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Язык: Английский

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Transforming Toxicity Assessment through Microphysiology, Bioprinting, and Computational Modeling

Advances in Clinical Toxicology, Год журнала: 2024, Номер 9(1), С. 1 - 14

Опубликована: Янв. 1, 2024

Background: Traditional toxicity testing emphasizes animal models with growing concerns regarding predictive capacity, throughput and ethics. Rapid innovation surrounding human cell platforms, bioengineered tissues, omics techniques computational tools offers more modern alternatives aligned expanding knowledge of chemical biological pathways. These disruptive approaches promise immense potential to transform next-generation safety assessment drug development pipelines. Purpose: This review provides clinical researchers an updated, comprehensive perspective across evolving areas focus in new methods analysis latest advances translational context. Main Body: We survey progress two- three-dimensional cultures recapitulating tissue/organ complexity impossible conventional assays. Complementing this, modeling integrates structure-activity relationships, physicochemical properties physiological interactions predict pharmacokinetics silico. Expanding model organisms add further dimensionality demographic relevance. High-throughput imaging technologies unravel mechanisms illuminate biomarkers undetectable by standard measures. Specialized show high addressing toxicodynamic intricacies within disease contexts like diabetes NAFLD. Evaluating traditional medicines phytochemicals likewise represents area growth well-suited for contemporary platforms. Future outlook weighs remarkable advantages reducing demands, enabling precision toxicology links medicine overhauling core risk frameworks. Conclusion: intends catalyze discourse on strategic optimization priorities roadmaps towards fully unlocking the yet still emerging public health these poising transformation sciences centered human-focused models.

Язык: Английский

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Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS)

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132552 - 132552

Опубликована: Сен. 14, 2023

Язык: Английский

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Screening androgen receptor agonists of fish species using machine learning and molecular model in NORMAN water-relevant list

Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133844 - 133844

Опубликована: Фев. 20, 2024

Язык: Английский

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Effects of Glyphosate or Glyphosate-Based Herbicide during the Zebrafish Life Cycle: A Review Addressing the Mechanisms of Toxicity

Water, Год журнала: 2023, Номер 15(12), С. 2276 - 2276

Опубликована: Июнь 17, 2023

Herbicides with glyphosate (GLY) as an active ingredient (a.i.) are increasingly used, and GLY is currently the most used herbicide in world. Consequently, its residues have often been found aquatic ecosystems. Investigating how this substance affects species a priority ecotoxicology research, especially fish, they can absorb concentrate toxins. In sense, critical review was performed, synthesizing data from peer-reviewed bibliography, reporting on toxicity of exposure to pure glyphosate-based herbicides (GBHs), using zebrafish animal model. The concentrations that induced toxic effects highly variable, some exceeding limits determined by regulatory agencies. Globally, relevant reported zebrafish, namely, teratogenic incompatible life, which translates directly into increase mortality. Neurotoxicity, genotoxicity, changes energy metabolism oxidative stress, immune hormonal system dysfunction impact fish reproduction were also described. conclusion, both GBHs may induce damage compromising their survival, reproduction, maintenance. These results be valid applied other

Язык: Английский

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Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: A review

Aquatic Toxicology, Год журнала: 2024, Номер 272, С. 106977 - 106977

Опубликована: Май 27, 2024

Язык: Английский

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Common Toxicological Experimental Models

Опубликована: Янв. 14, 2025

Zebrafish as a model animal widely used in toxicological studies is highly sensitive to changes various environmental factors. Many factors including photoperiod, temperature, oxygen, etc., dangerous compounds such heavy metal Cu, Cd, Hg, Pb, and estrogen BPA, for instance, can cause reproductive toxicity zebrafish. The potential damage effects caused by the combined contaminants include abnormal gonad development, histopathological changes, reduced germ cell number quality, motility of spermatozoa, altered follicular size, egg production, steroid hormone biosynthesis, unbalanced levels gene expression, fertilization hatching success, larval juvenile viability, etc. This chapter describes parameters that characterize function zebrafish, well corresponding detection methods.

Язык: Английский

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Advancing Microplastic Detection in Zebrafish with Micro Computed Tomography: A Novel Approach to Revealing Microplastic Distribution in Organisms

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137442 - 137442

Опубликована: Янв. 1, 2025

The analysis of microplastics with current spectroscopic and pyrolytic methods is reaching its limits, especially regard to detailed spatial distribution in biological tissues. This limitation hampers a comprehensive understanding the effects on organisms. Therefore, there pressing need expand analytical approaches study biota. In this context, aim was test applicability non-destructive 3D imaging using X-ray micro-computed tomography (microCT) for detection fish. Zebrafish (Danio rerio) were gavaged polyethylene spherical (30-110 μm) gut investigated microCT. results showed that particle size determined by microCT closely matched data from conventional laser diffraction analysis. addition, able detect spiked fish tissue provide precise localization tracing particles known type shape. MicroCT offers novel approach tracking organisms enables accurate sizing without compromising integrity under investigation. It therefore represents valuable addition methods, which are widely used based their chemical composition but do not distribution.

Язык: Английский

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