Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum DOI Creative Commons
Yongzhao Zhao, Qian Xiang, Shuo Tian

и другие.

Experimental & Molecular Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Abstract Ligamentum flavum degeneration, including hypertrophy and ossification of the ligamentum flavum, leads to degenerative spinal stenosis in older adults. However, underlying mechanisms degeneration remain unclear, therapeutic strategies are limited. Noncoding RNAs include microRNAs, circular RNAs, long noncoding RNAs. As important epigenetic modifications, involved progression several age-related diseases, degeneration. Previous studies have shown that can regulate osteogenic differentiation fibrosis cells by regulating expression related genes. In this review, we discuss their role

Язык: Английский

Role of macrophage in intervertebral disc degeneration DOI Creative Commons

Yiming Dou,

Yiming Zhang, Yang Liu

и другие.

Bone Research, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

1
Exosomes derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by alleviating the senescence of nucleus pulposus cells through epigenetic modifications DOI
Yongzhao Zhao, Longting Chen, Shuai Jiang

и другие.

Bioactive Materials, Год журнала: 2025, Номер 49, С. 515 - 530

Опубликована: Март 20, 2025

Язык: Английский

Процитировано

0
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis DOI
Hongyuan Zhang, Ning Jiang, Mingyang Xu

и другие.

Life Sciences, Год журнала: 2025, Номер unknown, С. 123561 - 123561

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression DOI Creative Commons
Min Chien Tu, Anmin Liu,

Wei Huang

и другие.

Journal of Cell Communication and Signaling, Год журнала: 2025, Номер 19(2)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
FOXO3a overexpression ameliorates intervertebral disc degeneration by decreasing NLRP3-mediated pyroptosis DOI

Qi Min,

Chen Xu, Yifei Gu

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 144, С. 113596 - 113596

Опубликована: Ноя. 22, 2024

Язык: Английский

Процитировано

1
Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum DOI Creative Commons
Yongzhao Zhao, Qian Xiang, Shuo Tian

и другие.

Experimental & Molecular Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Abstract Ligamentum flavum degeneration, including hypertrophy and ossification of the ligamentum flavum, leads to degenerative spinal stenosis in older adults. However, underlying mechanisms degeneration remain unclear, therapeutic strategies are limited. Noncoding RNAs include microRNAs, circular RNAs, long noncoding RNAs. As important epigenetic modifications, involved progression several age-related diseases, degeneration. Previous studies have shown that can regulate osteogenic differentiation fibrosis cells by regulating expression related genes. In this review, we discuss their role

Язык: Английский

Процитировано

0