Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum DOI Creative Commons
Yongzhao Zhao, Qian Xiang, Shuo Tian

et al.

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Ligamentum flavum degeneration, including hypertrophy and ossification of the ligamentum flavum, leads to degenerative spinal stenosis in older adults. However, underlying mechanisms degeneration remain unclear, therapeutic strategies are limited. Noncoding RNAs include microRNAs, circular RNAs, long noncoding RNAs. As important epigenetic modifications, involved progression several age-related diseases, degeneration. Previous studies have shown that can regulate osteogenic differentiation fibrosis cells by regulating expression related genes. In this review, we discuss their role

Language: Английский

Role of macrophage in intervertebral disc degeneration DOI Creative Commons

Yiming Dou,

Yiming Zhang, Yang Liu

et al.

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 23, 2025

Language: Английский

Citations

1
Exosomes derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by alleviating the senescence of nucleus pulposus cells through epigenetic modifications DOI
Yongzhao Zhao, Longting Chen, Shuai Jiang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 515 - 530

Published: March 20, 2025

Language: Английский

Citations

0
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis DOI
Hongyuan Zhang, Ning Jiang, Mingyang Xu

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123561 - 123561

Published: March 1, 2025

Language: Английский

Citations

0
Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression DOI Creative Commons
Min Chien Tu, Anmin Liu,

Wei Huang

et al.

Journal of Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 19(2)

Published: April 22, 2025

Language: Английский

Citations

0
FOXO3a overexpression ameliorates intervertebral disc degeneration by decreasing NLRP3-mediated pyroptosis DOI

Qi Min,

Chen Xu, Yifei Gu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113596 - 113596

Published: Nov. 22, 2024

Language: Английский

Citations

1
Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum DOI Creative Commons
Yongzhao Zhao, Qian Xiang, Shuo Tian

et al.

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Ligamentum flavum degeneration, including hypertrophy and ossification of the ligamentum flavum, leads to degenerative spinal stenosis in older adults. However, underlying mechanisms degeneration remain unclear, therapeutic strategies are limited. Noncoding RNAs include microRNAs, circular RNAs, long noncoding RNAs. As important epigenetic modifications, involved progression several age-related diseases, degeneration. Previous studies have shown that can regulate osteogenic differentiation fibrosis cells by regulating expression related genes. In this review, we discuss their role

Language: Английский

Citations

0