Laser-activable murine ferritin nanocage for chemo-photothermal therapy of colorectal cancer

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 29, 2024

Abstract Chemotherapy, as a conventional strategy for tumor therapy, often leads to unsatisfied therapeutic effect due the multi-drug resistance and serious side effects. Herein, we genetically engineered thermal-responsive murine Ferritin (mHFn) specifically deliver mitoxantrone (MTO, chemotherapeutic photothermal agent) tissue chemotherapy combined therapy of colorectal cancer, thanks high affinity mHFn transferrin receptor that highly expressed on cells. The thermal-sensitive channels allowed effective encapsulation MTO in vitro laser-controlled release vivo. Upon irradiation with 660 nm laser, raised temperature triggered opening channel nanocage, resulting controlled rapid MTO. Consequently, significant amount reactive oxygen species was generated, causing mitochondrial collapse cell death. photothermal-sensitive release, low systemic cytotoxicity, excellent synergistic eradication ability vivo made mHFn@MTO promising candidate chemo-photothermal combination against cancer. Graphical

Язык: Английский

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Dual Oxygen‐Supply Immunosuppression‐Inhibiting Nanomedicine to Avoid the Intratumoral Recruitment of Myeloid‐Derived Suppressor Cells

Small, Год журнала: 2024, Номер unknown

Опубликована: Сен. 5, 2024

Abstract Myeloid‐derived suppressor cells (MDSCs) are reported to be responsible for the negative prognosis of colorectal cancer (CRC) patients due mediated immunosuppressive tumor microenvironment (TME). The selective and chronic circumvention tumor‐infiltrated MDSCs has potential clinical significance CRC treatment, which unluckily remains a technical challenge. Because hypoxia makes significant contribution recruitment in sites, dual oxygen‐supplied immunosuppression‐inhibiting nanomedicine (DOIN) is demonstrated overcoming hypoxia, achieves long‐term inhibition intratumoral MDSCs. DOIN constructed by encasement perfluorooctyl bromide (PFOB) 4‐methylumbelliferone (4‐MU) into TME‐responsive amphiphilic polymer. This nanoplatform directly carries oxygen region simultaneously loosens condensed extracellular matrix normalization vasculature, selectively remodels TME toward one adverse Importantly, this offers long‐acting alleviation hypoxic TME, chronically avoiding comeback Consequently, relieved, T successfully proliferated activated cytotoxic lymphocytes, boosts systemic immune response contributes lasting growth with prolonged survival span xenograft.

Язык: Английский

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Lanthanum-based dendritic mesoporous nanoplatform for tumor microenvironment activating synergistic anti-glioma efficacy

Materials Today Bio, Год журнала: 2024, Номер 28, С. 101223 - 101223

Опубликована: Сен. 3, 2024

Lanthanum (La)-based nanotherapeutics are therapeutically advantageous due to cytoplasmic oxygen species (ROS) levels for mediating intrinsic and extrinsic tumor cell apoptosis. While they have not been extensively explored their potential suppress malignancies

Язык: Английский

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Differential reinforcement of cGAS-STING pathway-involved immunotherapy by biomineralized bacterial outer membrane-sensitized EBRT and RNT

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 3, 2024

Abstract Radiotherapy (RT), including external beam radiation therapy (EBRT) and radionuclide (RNT), realizes physical killing of local tumors activates systemic anti-tumor immunity. However, these effects need to be further strengthened the difference between EBRT RNT should discovered. Herein, bacterial outer membrane (OM) was biomineralized with manganese oxide (MnO 2 ) obtain OM@MnO -PEG nanoparticles for enhanced radio-immunotherapy via amplifying EBRT/RNT-induced immunogenic cell death (ICD) cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) activation. can react H O then gradually produce , Mn 2+ OM fragments in tumor microenvironment. The relieved hypoxia improves radio-sensitivity cells, resulting ICD DNA damage. together cytoplasm activate cGAS-STING pathway, exhibiting a positive role various aspects innate immunity adaptive Besides, promote antigen presentation macrophages polarization. More importantly, our study reveals that -PEG-mediated triggers much stronger pathway-involved immunotherapy than EBRT, owing duration RT. Therefore, this develops powerful sensitizer uncovers some differences activation pathway-related Graphical

Язык: Английский

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Boosting Oxidative Stress with Hydroxyethyl Starch Smart Nanomedicines to Eliminate Cancer Stem Cells

Accounts of Materials Research, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

ConspectusThe significance of cancer stem cells (CSCs), a rare population in tumor tissues, biology and the treatment solid malignancies has been widely appreciated for more than two decades. Due to peculiar self-renewal capability, even one single cell can grow into bulk mass. For this reason, CSCs have long blamed as major culprit initiation, progression, resistance, metastasis, recurrence. Therefore, it postulated that targeting could provide tremendous clinical benefits patients with tumors. Accumulating studies corroborated maintained tight regulation redox homeostasis fate was extremely sensitive elevated oxidative stress. Accordingly, plethora therapeutic drugs generate reactive oxygen species (ROS) leveraged target CSCs. Nonetheless, few or formulations are capable elevating stress achieved success eliminating thus far.Hydroxyethyl starch (HES) utilized plasma volume expander settings 50 years. Owing its merits excellent biocompatibility biodegradability, good water solubility manufacture practice, abundant hydroxy groups easy chemical modifications, HES attracted great attention tumor-targeted drug delivery. Specifically, nanoparticle stabilizer, nanocarrier conjugate chemotherapeutic by stimuli-responsive linkers, hydrophilic polymer link hydrophobic polymers form self-assembled nanoparticles. In Account, we summarize smart nanomedicines, developed our group during past five years, boost CSC elimination. According their effects on homeostasis, categorize these nanomedicines three classes. The first ones excessive ROS, means mitochondria-targeted photodynamic therapy (Mito-PDT), cuproptosis, ferroptosis. second own capability counteract endogenous reducing substances via inhibiting glutaminolysis depleting glutathione (GSH). third types simultaneously amplify ROS generation suppress antioxidant agents through combination strategies Mito-PDT plus inhibition, dynamic (CDT) GSH depletion, CDT depletion well inhibition. These rationally designed not only vitro but also eliminate numerous tumor-bearing mice models vivo, giving novel insights anti-CSC therapy. As is used clinic, hold significant potential translation.

Язык: Английский

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Post-translational modifications: The potential ways for killing cancer stem cells

Heliyon, Год журнала: 2024, Номер 10(14), С. e34015 - e34015

Опубликована: Июль 1, 2024

While strides in cancer treatment continue to advance, the enduring challenges posed by metastasis and recurrence persist as formidable contributors elevated mortality rates observed patients. Among multifaceted factors implicated tumor metastasis, stem cells (CSCs) emerge noteworthy entities due their inherent resistance conventional therapies heightened invasive capacities. Characterized notable abilities for self-renewal, differentiation, initiation of tumorigenesis, eradication CSCs emerges a paramount objective. Recent investigations increasingly emphasize pivotal role post-translational protein modifications (PTMs) governing self-renewal replication capabilities CSCs. This review accentuates critical significance several prevalent PTMs intricate interplay PTM crosstalk regulating CSC behavior. Furthermore, it posits that manipulation may offer novel avenue targeting eliminating populations, presenting compelling perspective on therapeutics with substantial potential future applications.

Язык: Английский

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Azaindole-based asymmetric pentamethine cyanine dye for mitochondrial pH detection and near-infrared ratiometric fluorescence imaging of mitophagy

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110408 - 110408

Опубликована: Сен. 1, 2024

Язык: Английский

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Supramolecular nanomedicine in the intelligent cancer therapy: recent advances and future

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 11, 2024

In recent years, the incidence of cancer has been increasing year by year, and burden disease economic caused it worsening. Although chemotherapy, immunotherapy, targeted therapy other therapeutic means continue to progress, they still inevitably have problems such as high toxicity side effects, susceptibility drug resistance, price. Photothermal photodynamic demonstrated considerable advantages in imaging treatment due their minimally invasive selective nature. However, development constrained challenges related delivery. times, delivery systems constructed based on supramolecular chemistry subject interest, particularly view compatibility with permeability long retention effect tumors. Furthermore, advantage dissociating active ingredient under pH, light stimuli makes them unique therapy. This paper reviews current status nanomedicines therapy, elucidating faced providing a theoretical basis for efficient precise malignant

Язык: Английский

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An object detection-based model for automated screening of stem-cells senescence during drug screening

Neural Networks, Год журнала: 2024, Номер 183, С. 106940 - 106940

Опубликована: Ноя. 23, 2024

Язык: Английский

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