Neurosteroids as emerging therapeutics for treatment-resistant depression: Mechanisms and clinical potential DOI

Krutika Nagpurkar,

Pratik Ghive,

Mayur B. Kale

и другие.

Neuroscience, Год журнала: 2025, Номер 577, С. 300 - 314

Опубликована: Май 19, 2025

Язык: Английский

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

и другие.

Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

2
Pharmacological landscape of endoplasmic reticulum stress: uncovering therapeutic avenues for metabolic diseases DOI
Ghallab Alotaibi,

Abdullah Alkhammash

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177509 - 177509

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Treatment effect and safety of seltorexant as monotherapy for patients with major depressive disorder: a randomized, placebo-controlled clinical trial DOI Creative Commons

Sofie Mesens,

Iva Kezic,

Peter van der Ark

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

The antidepressant efficacy and safety of seltorexant monotherapy in major depressive disorder (MDD) was investigated a placebo-controlled, placebo lead-in, randomized, double-blind, phase 1b study. Participants were randomized to receive (20 mg or 40 mg) placebo. treatment effect assessed by changes the Hamilton Rating Scale for Depression-17 item (HDRS

Язык: Английский

Процитировано

4
Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity DOI Creative Commons
Shuntaro Izawa, Debora Fuscà, Hong Jiang

и другие.

Cell Reports, Год журнала: 2025, Номер 44(2), С. 115277 - 115277

Опубликована: Фев. 1, 2025

Highlights•Ox2R is expressed in distinct molecular sub-populations of MCH neurons•Orexin B elicits excitatory and inhibitory responses neurons•Ox2R inactivation neurons impairs REM sleep female mice•Ox2R insulin sensitivity miceSummaryOrexin/hypocretin receptor type 2 (Ox2R), which widely the brain, receives orexin signals modulates metabolism. Ox2R selective agonists are currently under clinical trials for narcolepsy treatment. Here, we focused on expression function melanin-concentrating hormone (MCH) neurons, have opposite roles to metabolism regulation. Ox2R-expressing showed heterogeneity RNA expression, application brain slices induced both neuron populations. reduced transitions from non-rapid eye movement (NREM) impaired with excessive feeding after a fasting period mice. In conclusion, mediates vivo, regulate mice.Graphical abstract

Язык: Английский

Процитировано

0
Cytokines in age-related eye diseases: pathogenesis and potential targets for innovative therapies DOI
Tingting Zhang,

Ming Liu

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The buffering effects of mindfulness and organizational support on the mental health of hospital pharmacists in high-workload environments DOI Creative Commons
Shazia Rehman,

Khalid Abdullah Alotaibi,

Erum Rehman

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0
Diabetic retinopathy detection based on mobile maxout network and weber local descriptor feature selection using retinal fundus image DOI Creative Commons
V Sheeja Kumari,

K. Sundravadivelu,

S. Pushparani

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Immune-related biomarkers in the neuromyelitis optica spectrum disorder; pathogenesis and therapeutic approaches DOI

Jingyong Li,

Yoshiyuki Dan,

Wei Su

и другие.

Experimental Eye Research, Год журнала: 2025, Номер unknown, С. 110395 - 110395

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Optimizing diabetic retinopathy detection with electric fish algorithm and bilinear convolutional networks DOI Creative Commons

Udayaraju Pamula,

Venkateswararao Pulipati, Gamini Suresh

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 23, 2025

Diabetic Retinopathy (DR) is a leading cause of vision impairment globally, necessitating regular screenings to prevent its progression severe stages. Manual diagnosis labor-intensive and prone inaccuracies, highlighting the need for automated, accurate detection methods. This study proposes novel approach early DR by integrating advanced machine learning techniques. The proposed system employs three-phase methodology: initial image preprocessing, blood vessel segmentation using Hopfield Neural Network (HNN), feature extraction through an Attention Mechanism-based Capsule (AM-CapsuleNet). features are optimized Taylor-based African Vulture Optimization Algorithm (AVOA) classified Bilinear Convolutional (BCAN). To enhance classification accuracy, introduces hybrid Electric Fish Arithmetic (EFAOA), which refines exploration phase, ensuring rapid convergence. model was evaluated on balanced dataset from APTOS 2019 Blindness Detection challenge, demonstrating superior performance in terms accuracy efficiency. offers robust solution DR, potentially improving patient outcomes timely precise diagnosis.

Язык: Английский

Процитировано

0
Neuroadaptation in neurodegenerative diseases: compensatory mechanisms and therapeutic approaches DOI

Spandana Rajendra Kopalli,

Tapan Behl, Lalji Baldaniya

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер 139, С. 111375 - 111375

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0