Neurosteroids as emerging therapeutics for treatment-resistant depression: Mechanisms and clinical potential DOI

Krutika Nagpurkar,

Pratik Ghive,

Mayur B. Kale

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 577, P. 300 - 314

Published: May 19, 2025

Language: Английский

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Pharmacological landscape of endoplasmic reticulum stress: uncovering therapeutic avenues for metabolic diseases DOI
Ghallab Alotaibi,

Abdullah Alkhammash

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177509 - 177509

Published: March 1, 2025

Language: Английский

Citations

1
Cytokines in age-related eye diseases: pathogenesis and potential targets for innovative therapies DOI
Tingting Zhang,

Ming Liu

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
The buffering effects of mindfulness and organizational support on the mental health of hospital pharmacists in high-workload environments DOI Creative Commons
Shazia Rehman,

Khalid Abdullah Alotaibi,

Erum Rehman

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 8, 2025

Language: Английский

Citations

0
Optimizing diabetic retinopathy detection with electric fish algorithm and bilinear convolutional networks DOI Creative Commons

Udayaraju Pamula,

Venkateswararao Pulipati,

Gamini Suresh

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 23, 2025

Diabetic Retinopathy (DR) is a leading cause of vision impairment globally, necessitating regular screenings to prevent its progression severe stages. Manual diagnosis labor-intensive and prone inaccuracies, highlighting the need for automated, accurate detection methods. This study proposes novel approach early DR by integrating advanced machine learning techniques. The proposed system employs three-phase methodology: initial image preprocessing, blood vessel segmentation using Hopfield Neural Network (HNN), feature extraction through an Attention Mechanism-based Capsule (AM-CapsuleNet). features are optimized Taylor-based African Vulture Optimization Algorithm (AVOA) classified Bilinear Convolutional (BCAN). To enhance classification accuracy, introduces hybrid Electric Fish Arithmetic (EFAOA), which refines exploration phase, ensuring rapid convergence. model was evaluated on balanced dataset from APTOS 2019 Blindness Detection challenge, demonstrating superior performance in terms accuracy efficiency. offers robust solution DR, potentially improving patient outcomes timely precise diagnosis.

Language: Английский

Citations

0
Neuroadaptation in neurodegenerative diseases: compensatory mechanisms and therapeutic approaches DOI

Spandana Rajendra Kopalli,

Tapan Behl, Lalji Baldaniya

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 139, P. 111375 - 111375

Published: April 23, 2025

Language: Английский

Citations

0
Hybrid Neural network and machine learning models with improved optimization method for gut microbiome effects on the sleep quality in patients with endometriosis DOI
Hui Deng, Li Pan

Computer Methods and Programs in Biomedicine, Journal Year: 2025, Volume and Issue: 267, P. 108776 - 108776

Published: April 26, 2025

Language: Английский

Citations

0
Matrix metalloproteinase-9 (MMP-9): A macromolecular mediator in CNS infections: A review DOI
Mohamad Mosa Mubarak,

Ishfaq Ahmad Baba,

Zubair Ahmad Wani

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143902 - 143902

Published: May 4, 2025

Language: Английский

Citations

0
Treatment effect and safety of seltorexant as monotherapy for patients with major depressive disorder: a randomized, placebo-controlled clinical trial DOI Creative Commons

Sofie Mesens,

Iva Kezic,

Peter van der Ark

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

The antidepressant efficacy and safety of seltorexant monotherapy in major depressive disorder (MDD) was investigated a placebo-controlled, placebo lead-in, randomized, double-blind, phase 1b study. Participants were randomized to receive (20 mg or 40 mg) placebo. treatment effect assessed by changes the Hamilton Rating Scale for Depression-17 item (HDRS

Language: Английский

Citations

3
Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity DOI Creative Commons
Shuntaro Izawa, Debora Fuscà, Hong Jiang

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115277 - 115277

Published: Feb. 1, 2025

Highlights•Ox2R is expressed in distinct molecular sub-populations of MCH neurons•Orexin B elicits excitatory and inhibitory responses neurons•Ox2R inactivation neurons impairs REM sleep female mice•Ox2R insulin sensitivity miceSummaryOrexin/hypocretin receptor type 2 (Ox2R), which widely the brain, receives orexin signals modulates metabolism. Ox2R selective agonists are currently under clinical trials for narcolepsy treatment. Here, we focused on expression function melanin-concentrating hormone (MCH) neurons, have opposite roles to metabolism regulation. Ox2R-expressing showed heterogeneity RNA expression, application brain slices induced both neuron populations. reduced transitions from non-rapid eye movement (NREM) impaired with excessive feeding after a fasting period mice. In conclusion, mediates vivo, regulate mice.Graphical abstract

Language: Английский

Citations

0