The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases—Therapeutic Approaches: A Comprehensive Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10041 - 10041

Опубликована: Сен. 18, 2024

The objective of this review is to provide a comprehensive examination the role microbial metabolites in progression neurodegenerative diseases, as well investigate potential therapeutic interventions targeting microbiota. A literature search was conducted across following databases: PubMed, Scopus, Web Science, ScienceDirect, and Wiley. Key terms related gut microbiota, metabolites, specific metabolic products were used. included both preclinical clinical research articles published between 2000 2024. Short-chain fatty acids have been demonstrated play crucial modulating neuroinflammation, preserving integrity blood–brain barrier, influencing neuronal plasticity protection. Furthermore, amino their derivatives exert significant influence on CNS function. These impact health by regulating intestinal permeability, immune responses, directly neuroinflammation oxidative stress, which are integral diseases. Therapeutic strategies, including prebiotics, probiotics, dietary modifications, fecal microbiota transplantation confirmed restore balance enhance production neuroprotective metabolites. novel drug developments based present promising avenues. its represent field with advance our understanding develop treatments for

Язык: Английский

The microbiome’s influence on obesity: mechanisms and therapeutic potential

Science China Life Sciences, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский