Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 12
Опубликована: Янв. 9, 2025
Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles are smaller than 100 nm, secreted by most cell types brain. Regulation cell-cell communication, neuroregeneration, synapse formation exosomes have been extensively studied. However, interaction between axon molecules poorly understood. This review summarizes relationship canonical non-canonical cues hypothesizes possible model for mediating cells. The roles outgrowth, regeneration, neurodevelopmental disorders also reviewed, discuss exosome-guidance interactions as potential clinical therapeutic targets.
Язык: Английский
Процитировано
1
Advanced Biology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Diseases of the nervous system are recognized as second leading cause death worldwide. The global prevalence neurological diseases, such Huntington's disease, Alzheimer's and Parkinson's disease has seen a significant rise due to increasing proportion aging population. discovery clustered regularly interspaced short palindromic repeats (CRISPR) genome editing technique paved way for universal diseases treatment. However, finding safe effective method deliver CRISPR gene‐editing tools remains main challenge therapies in vivo. Adeno‐associated virus (AAV) is currently one most commonly used vector systems, but some issues remain unresolved, including capsid immunogenicity, off‐target mutations, potential genotoxicity. To address these concerns, researchers actively encouraging development new delivery like virus‐like particles nanoparticles. These novel systems have enhance targeting efficiency, thereby offering possible solutions current challenges. This article reviews vectors disorders treatment explores overcome limitations systems. Additionally, strategies highlighted valuable studying challenges opportunities that present.
Язык: Английский
Процитировано
1
Frontiers in Neurology, Год журнала: 2025, Номер 15
Опубликована: Янв. 7, 2025
HIV-associated neurocognitive disorder (HAND) is a complex neurological complication resulting from human immunodeficiency virus (HIV) infection, affecting about 50% of individuals with HIV and significantly diminishing their quality life. HAND includes variety cognitive, motor, behavioral disorders, severely impacting patients' life social functioning. Although combination antiretroviral therapy (cART) has greatly improved the prognosis for patients, incidence remains high, underscoring urgent need to better understand its pathological mechanisms develop early diagnostic methods. This review highlights latest advancements in neuroimaging exosome biomarkers research. Neuroimaging, particularly magnetic resonance imaging (MRI), offers non-invasive repeatable method monitor subtle changes brain structure function, potentially detecting signs HAND. Meanwhile, exosomes are nano-sized vesicles secreted by cells that serve as key mediators intercellular communication, playing crucial role neuropathology acting critical bridge between peripheral blood central nervous system lesions. Thus, combining plasma indicators derived scans may enhance diagnosis summarizes evidence supporting reliable detection management Furthermore, we emphasize correlation explore potential combined use. discusses technical challenges methodological limitations integrating these two types proposes future research directions. multidisciplinary integrative approach not only promises improve health patients but also offer valuable insights into other neurodegenerative diseases.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142829 - 142829
Опубликована: Апрель 1, 2025
Exosomes are tiny extracellular membrane vesicles produced by various biological sources that have gained significant attention due to their theranostic potential. They carry macromolecules such as proteins, DNA, and RNA (including miRNAs) involved in intercellular communication within the central nervous system (CNS). This review summarizes role of exosomes miRNAs aspects depression, emphasizing therapeutic potential depression applications drug delivery systems. modulating critical pathways neurogenesis, synaptic plasticity, blood-brain barrier integrity, neuroinflammation, neural development. reduce neuroinflammation suppressing cytokine production immune activation. Furthermore, facilitate neuronal repair which is important for restoring circuitry, cognitive abilities, emotional mental stability affected depression. Moreover, exosomal emerging targets both diagnostic treatment perspectives treatment. The regulate gene expressions associated with functions health serve biomarkers novel approaches. In conclusion, may play a crucial will enhance probability successful
Язык: Английский
Процитировано
0
Translational Psychiatry, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 12, 2025
Postpartum depression (PPD) significantly impacts women's mental health and social functioning, yet effective therapies remain limited. This study investigates the preventive effects of music therapy on PPD-like behaviors underlying neurobiological mechanisms in a mouse model subjected to ovarian hormone withdrawal (HW). Mice exposed daily sessions exhibited markedly reduced depression- anxiety-like behaviors, as evidenced by enhanced performance behavioral tests such open field test (OFT), forced swim (FST), elevated plus maze (EPM), sucrose preference (SPT), novelty-suppressed feeding (NSF) test, tail suspension (TST). Furthermore, normalized oxidative stress indicators (NO, MDA, SOD, CAT, GSH-Px, T-AOC, ATP, glutamate) serum, hippocampus, prefrontal cortex. Additionally, exposure levels proinflammatory factors (IL-6, IL-1β, iNOS, TNF-α, TGF-β) activation microglia astrocytes these brain regions. Notably, preserved neuronal integrity, promoted neurogenesis, maintained synaptic plasticity, restoration dendritic spines. Transcriptome sequencing identified differential gene expression pathways related inflammation, stress. These findings suggest that prevents PPD modulating stress, providing robust preclinical evidence for its potential natural intervention PPD. underscores need further clinical research validate therapeutic efficacy preventing humans, highlighting promise non-invasive accessible treatment modality.
Язык: Английский
Процитировано
0
Journal of Neuroimmunology, Год журнала: 2025, Номер 405, С. 578623 - 578623
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 3, 2025
The blood-brain barrier (BBB) presents a formidable challenge in neuropharmacology, limiting the delivery of therapeutic agents to brain. Exosomes, nature's nanocarriers, have emerged as promising solution due their biocompatibility, low immunogenicity, and innate ability traverse BBB. A thorough examination BBB anatomy physiology reveals complexities neurological drug underscores limitations conventional methods. This review explores potential exosome-powered neuropharmaceutics, highlighting structural functional properties, biogenesis, mechanisms release. Their intrinsic advantages delivery, including enhanced stability efficient cellular uptake, are discussed detail. Exosomes naturally overcome barriers through specific translocation mechanisms, making them compelling vehicle for targeted brain therapies. Advances engineering strategies, such genetic biochemical modifications, loading techniques, specificity enhancement, further bolster potential. Exosome-based approaches hold immense promise treating spectrum disorders, Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS), multiple (MS), tumors, stroke, psychiatric conditions. By leveraging properties innovations, exosomes offer versatile platform precision neurotherapeutics. Despite promise, challenges remain clinical translation, large-scale production, standardization, regulatory considerations. Future research directions exosome nanobiotechnology aim refine these unlocking new avenues diseases. transformative impact exosome-based paving way next-generation therapies that can effectively penetrate revolutionize neuropharmacology.
Язык: Английский
Процитировано
0
Translational Psychiatry, Год журнала: 2025, Номер 15(1)
Опубликована: Май 9, 2025
Язык: Английский
Процитировано
0
Frontiers in Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Май 12, 2025
Neurological disorders represent a major global health concern owing to their intricate pathological processes. Ferroptosis, defined as form of cell death that is reliant on iron, has been closely linked various neurological conditions. The fundamental process underlying ferroptosis by the excessive buildup iron ions, which initiates lipid peroxidation processes leading cellular demise. Neurons, highly metabolically active cells, are susceptible oxidative stress, and imbalances in metabolism can directly initiate process. In neurodegenerative like Alzheimer’s disease Parkinson’s disease, driven accumulation represents connection. Although connection between diseases clear, clinical application still faces challenges, such precise regulation metabolism, development specific drugs, assessment efficacy. limited comprehension mechanism hinders personalized treatment approaches. Consequently, subsequent investigations must tackle these obstacles facilitate ferroptosis-associated therapies disorders. This article provides comprehensive overview most recent advancements regarding mechanisms ferroptosis. Subsequently, study investigates mechanistic contributions within nervous system. conclusion, we evaluate deliberate targeted therapeutic strategies associated with
Язык: Английский
Процитировано
0
BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)
Опубликована: Май 13, 2025
Abstract Background Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine, improves the depression and anxiety in humans animals, rendering it novel therapeutic option for post-stroke (PSD). Furthermore, physical exercise is an important nonpharmacological therapy major depressive disorder. The components of NYT or exert antidepressant effects through increased expression neurotrophic factors reduced neuroinflammation brain. However, mechanisms underlying PSD remain unclear. Therefore, we examined rat model PSD. Methods Rats were divided into five groups: PSD, with NYT, (Ex), (NYT + Ex), control (sham). was induced by microinjection endothelin-1 left medial prefrontal cortex chronic unpredictable mild stress 3 days per week. A diet containing 3% administered to rats one day after stroke induction. Exercise conducted using motorized treadmill three week, starting stroke. interventions lasted four weeks. Serum corticosterone levels, depression-like behavior, hippocampal pathophysiology, including brain-derived factor (BDNF), precursor BDNF (proBDNF), doublecortin (DCX), NeuN, glial cell activation, tumor necrosis factor-α (TNF-α), examined. Results levels lower treatment group than those group. Notably, serum significantly CA1 region higher Ex that showed BDNF/proBDNF ratio other groups. DCX NeuN Hippocampal activation TNF-α decreased intervention Conclusions ameliorates Additionally, this study suggested together therapy, may improve neurogenesis, ratio, hippocampus Clinical trial number Not applicable.
Язык: Английский
Процитировано
0