Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing

Smart Medicine, Год журнала: 2025, Номер 4(1)

Опубликована: Фев. 26, 2025

Wound healing has been a continuous critical focus in clinical practice, posing the ongoing challenges and burdens to patients. Current attempts tend develop multi-drug loaded patches with spatial design. Herein, we present multifunctional microneedle patch that integrates different drugs into separated regions for wound treatment. The is composed of silk fibroin-methacryloyl (SilMA) as base, silver nanoparticles (AgNPs) gelatin methacryloyl (GelMA) tips vascular endothelial growth factor (VEGF). backing endowed antimicrobial properties by AgNPs act an barrier against bacterium invasion. In addition, encapsulated VEGF can effectively promote cell proliferation angiogenesis, which favorable repair. Based on these characteristics, such integrated system significantly prevented bacterial infection promoted vivo. Therefore, it conceived find more practical values other fields.

Язык: Английский

MXene‐Integrated Responsive Hydrogel Microneedles for Oral Ulcers Healing

Smart Medicine, Год журнала: 2025, Номер 4(1)

Опубликована: Фев. 26, 2025

Glucocorticoids such as dexamethasone have shown promising therapeutic effects in conquering oral ulcers. Challenges this area are focused on enhancing the localized curative and responsive release. Herein, we presented a novel MXene-integrated hydrogel microneedle delivering to promote healing of ulceration. By loading MXene, microneedles enable NIR (Near Infrared)-responsive release inner for inflammation control tissue regeneration. In addition, MXene-induced local hyperthermia could inhibit bacteria, preventing possible infection ulcer lesions cavity. Based these features, demonstrated that our strategy relieve inflammation, reconstruction, accelerate wound rat models. Overall, NIR-responsive show significant promise promoting bring new ways disease treatment.

Язык: Английский

UV light-induced photodegradation of condensed tannins: obtaining bayberry tannins with different mean polymerization degrees

Wood Science and Technology, Год журнала: 2024, Номер 59(1)

Опубликована: Ноя. 7, 2024

Язык: Английский