Cost burden of cirrhosis and liver disease progression in metabolic dysfunction–associated steatohepatitis: A US cohort study

Journal of Managed Care & Specialty Pharmacy, Год журнала: 2024, Номер 30(9), С. 929 - 941

Опубликована: Июнь 7, 2024

Metabolic dysfunction-associated steatohepatitis (MASH), formerly nonalcoholic steatohepatitis, is characterized by fat accumulation and inflammation of the liver may result in progression to cirrhosis liver-related events.

Язык: Английский

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Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series

Diseases, Год журнала: 2023, Номер 11(4), С. 141 - 141

Опубликована: Окт. 13, 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has generated an unprecedented challenge for healthcare systems worldwide. Currently, the scientific community wonders if liver injury in patients suffering from forms is a direct consequence of virus or secondary manifestations systemic inflammation. plays essential role development inflammatory storm typical this disease, and its involvement associated with worse clinical outcomes higher risk morbidity mortality Coronavirus disease 2019 (COVID-19).Ten COVID-19 who died between January 2020 December 2021 were included present analysis. These subjects underwent post mortem examination focused evaluation hepatic injury. Also, several laboratory parameters have been evaluated, primary focus on prothrombin time, partial thromboplastin fibrinogen, antithrombin III, D-dimers to detect coagulative changes.The main cause death was represented by pulmonary thromboembolism events (50%). analysis coagulation biomarkers revealed statistically significant rise aPTT ALP, decrease albumin, when comparing blood value at admission death. We also found high levels most time hospitalization. Interestingly, showed ample morphologic variability, features. In detail, histology following: presence variable degree micro- macrovacuolar steatosis, inflammation (also, hepato-cholangitis), fibrosis. Of mention, we able organized fibrinous material.Our results indicate that form COVID-19, related changes fibrinolytic pathways. particular, noted low fibrinogen D-dimer histological findings. Our data suggest may be used as prognostic markers severity COVID-19. Finally, underline crucial balance

Язык: Английский

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Molecular mechanisms underlying SARS-CoV-2 hepatotropism and liver damage

World Journal of Hepatology, Год журнала: 2024, Номер 16(1), С. 1 - 11

Опубликована: Янв. 23, 2024

In coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily targets the system, but evidence suggests extrapulmonary organ involvement, notably in liver. Viral RNA has been detected hepatic tissues, and situ hybridization revealed virions blood vessels endothelial cells. Electron microscopy confirmed viral particles hepatocytes, emphasizing need for understanding hepatotropism direct cytopathic effects COVID-19-related liver injury. Various factors contribute to injury, including cytotoxicity, vascular changes, inflammatory responses, immune reactions from COVID-19 vaccinations, drug-induced Although a typical hepatitis presentation is not widely documented, elevated biochemical markers are common hospitalized patients, showing hepatocellular pattern of elevation. Long-term studies suggest progressive cholestasis may affect 20% patients with chronic post-SARS-CoV-2 infection. The molecular mechanisms underlying SARS-CoV-2 infection resulting damage complex. This “Editorial” highlights expression Angiotensin-converting enzyme-2 receptor cells, role impact hypoxia, involvement liver's bile duct epithelial activation stellate contribution monocyte-derived macrophages. It also mentions that pre-existing conditions can worsen outcomes COVID-19. Understanding interaction still evolving, further research required.

Язык: Английский

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Unveiling metabolic dysfunction-associated fatty liver disease: Knowledge gaps and attitudes among Lebanese university students

PLoS ONE, Год журнала: 2024, Номер 19(8), С. e0306825 - e0306825

Опубликована: Авг. 2, 2024

Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a rapidly growing global health problem. Despite its incidence and potential for significant repercussions, MAFLD still widely misunderstood underdiagnosed. Aim The purpose of this study was to investigate MAFLD-related knowledge, attitudes, risk profiles among university students aged 17 26. Methods A cross-sectional with 406 in Lebanon, equally distributed males females, conducted using questionnaire that includes demographics, medical information, dietary habits, physical activity, knowledge attitudes. Results findings demonstrated lack regarding MAFLD, more than half participants (54.7%) having no prior the illness. Students exhibited unhealthy lifestyle behaviors such as smoking (68%), insufficient exercise (44.1%), poor food habits (52.5%). Having family history heart disease, personal diabetes mellitus, balanced diet were associated higher score (p<0.05). attitude existed those who have or chronic diseases negative impression about are physically active Conclusion gaps, Lebanon have, general, an appropriate positive towards MAFLD. We recommend introduction focused educational interventions address necessity changes community whole. Developing comprehensive prevention methods requires future studies different age groups demographics

Язык: Английский

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Health in All Policies: Working Across Sectors in Cooperative Extension to Promote Health for All

Journal of Human Sciences and Extension, Год журнала: 2018, Номер unknown

Опубликована: Май 14, 2018

A Health in All Policies approach engages cross-sector stakeholders to collaboratively improve systems that drive population health. We, the members of Extension Committee on Organization and Policy (ECOP)’s Action Team, propose adopting a within national Cooperative System will better prepare us contribute meaningfully improving nation’s We first explain argue for why how it is relevant Extension. then present insights gathered from Family Consumer Sciences program leaders state specialists assess whether leadership are poised adopt their affiliated programs. Although participant saw value contributing health improvement, they generally system as having lower levels readiness such an approach. Six themes emerged ways increase Extension’s engagement Policies: paradigm shift Extension, professional development competencies, transformational support, continued new partnerships, information access all disciplines

Язык: Английский

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Editor-in-Chief articles of choice and comments at the year-end of 2023

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(1), С. 1 - 8

Опубликована: Янв. 6, 2024

As the Editor-in-Chief of

Язык: Английский

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Is Steatotic Liver Disease Related to Poor Outcome in COVID-19-Hospitalized Patients?

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(9), С. 2687 - 2687

Опубликована: Май 3, 2024

Background: Steatotic liver disease (SLD) has been linked to more exacerbated inflammatory responses in various scenarios. The relationship between SLD and COVID-19 prognosis remains unclear. Our aim was investigate the impact of on outcome COVID-19. Methods: Patients hospitalized with confirmed who underwent laboratory tests chest CT scans were included. assessed by measuring attenuation coefficient scans. SLD, severity clinical presentation in-hospital mortality assessed. Results: A total 610 patients included (mean age 62 ± 16 years, 64% male). prevalence 30%, overall rate 19%. younger (58 13 vs. 64 p < 0.001) had a higher BMI (32 5 28 4 kg/m2, = 0.014). Admission AST values (82 339 50 37, 0.02), while D-dimer (1112 2147 1959 8509, 0.07), C-reactive protein (12 9 11 8, 0.27), ALT (67 163 47 90, 0.11), ALP (83 52 102 125, GGT (123 125 104 146, 0.61) did not significantly differ compared without SLD. No difference observed regarding lung parenchyma involvement >50% (20% 17%, 0.25), hospital length stay (14 19 23 days, 0.20), hemodialysis support (14% 16%, 0.57), use mechanical ventilation 20%, 0.96), (17% 0.40) when comparing Conclusions: showed no significant association morbidity

Язык: Английский

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Impact of non-alcoholic fatty liver disease on coronavirus disease 2019: A systematic review

World Journal of Hepatology, Год журнала: 2024, Номер 16(8), С. 1185 - 1198

Опубликована: Авг. 22, 2024

Many studies have revealed a link between non-alcoholic fatty liver disease (NAFLD) and coronavirus 2019 (COVID-19), making understanding the relationship these two conditions an absolute requirement.

Язык: Английский

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Cholesterol and Cholesterol-Lowering Medications in COVID-19—An Unresolved Matter

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10489 - 10489

Опубликована: Сен. 29, 2024

Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause disease 2019 (COVID-19), a very heterogeneous symptoms. Dyslipidaemia is prevalent in at least 20% of Europeans, and dyslipidaemia before SARS-CoV-2 infection increases the risk for COVID-19 mortality by 139%. Many reports described reduced serum cholesterol levels virus-infected patients, particular those disease. The liver major organ lipid homeostasis hepatic dysfunction appears to occur one five patients infected SARS-CoV-2. Thus, infection, severity injury may be related impaired homeostasis. These observations prompted efforts assess therapeutic opportunities cholesterol-lowering medications reduce severity. majority studies implicate statins have beneficial effects on outcome COVID-19. Proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies also shown potential protect against This review describes relationship between systemic levels, PCSK9 are summarised. Finally, lung function, first affected SARS-CoV-2, described.

Язык: Английский

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ANTIOXIDANT, ANTIDIABETIC, ANTIBACTERIAL, AND ANTICANCER ACTIVITIES OF EGYPTIAN FENUGREEK

Sinai Journal of Applied Sciences/Sinai Journal of Applied Sciences , Год журнала: 2023, Номер 12(3), С. 0 - 0

Опубликована: Май 1, 2023

Fenugreek (FG) flour is a common plant used in Egypt to add flavour and colour food, keep food fresh, as medicine.The current study tested FG for its antioxidant, antidiabetic, antimicrobial anticancer activities.FG showed significant contents of phenolic flavonoid compounds, reflecting their nutraceutical behaviors.The EC 50 when DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging was 2476 ± 62.9 µg/mL, while the extract's concentration that inhabited ABTS (2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)) 37.13 1.24 µg/mL.FG could lower blood sugar, it an alpha-glucosidase inhibiton at > 1000 µg/mL.Almost 99% breast cancer cells were damaged by extract concentrations 100 μg/mL.FG successful activity against Escherichia coli ATCC 8739 µg/mL concentration.The promising usage functional additive different foods.

Язык: Английский

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